Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues

Human Reproduction

Volumn 20, Issue 12, 2005, Pages 3532-3538

  Chong, W S ^a   Kwan, P C ^a   Chan, L Y ^a   Chiu, P Y ^a   Cheung, T K ^b   Lau, T K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Divalent metal transporter 1; Early pregnancy; Fetal tissues; Human placenta; Metal transport

Indexed keywords

ISOPROTEIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; EMBRYONAL TISSUE; FEMALE; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; GENE SEQUENCE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; MOLECULAR MECHANICS; PLACENTA; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

EID: 28544447516     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei246     Document Type: Article

References (32)

1. 1+ transporter of intestinal cells. Am J Physiol Cell Physiol 284, C1525-C1530.
2. Bannon I, Portnoy ME, Olivi L, Lees PS, Culotta VC and Bressler JP (2002) Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun 295,978-984.
3. Brace RA, Hanson MA and Rodeck CH (1998) Fetus and Neonate. Volume 4: Body Fluids and Kidney Function. 1st edn, Cambridge University Press, Cambridge, UK.
4. Bressler JP, Olivi L, Cheong JH, Kim Y and Bannona D (2004) Divalent metal transporter 1 in lead and cadmium transport. Ann NY Acad Sci 1012,142-152.
5. Brophy PD and Robillard JE (2004) Functional development of the kidney in utero. In Polin RA, Fox WW and Abman SH (eds) Fetal and Neonatal Physiology. 3rd edn, WB Saunders, Philadelphia, USA, vol 2, pp 1229-1241.
6. Canonne-Hergaux F, Gruenheid S, Ponka P and Gros P (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93,4406-4417.
7. Canonne-Hergaux F, Fleming MD, Levy JE, Gauthier S, Ralph T, Picard V, Andrews NC and Gros P (2000) The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96,3964-3970.
8. Canonne-Hergaux F, Levy JE, Fleming MD, Montross LK, Andrews NC and Gros P (2001) Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97,1138-1140.
9. Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP and Riccardi D (2001) Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol 280, F803-F814.
10. Fleming MD, Trenor CI, Su MA, Foernzler D, Beier DR, Dietrich WF and Andrews NC (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16,383-386.
11. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD and Andrews NC (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95,1148-1153.
12. Fleming RE, Migas MC, Zhou X, Jiang J, Britton RS, Brunt EM, Tomatsu S, Waheed A, Bacon BR and Sly WS (1999) Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci USA 96,3143-3148.
13. Forbes JR and Gros P (2003) Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood 102,1884-1892.
14. Gambling L, Danzeisen R, Fosset C, Andersen HS, Dunford S, Srai SK and McArdle JH (2003) Iron and copper interactions in development and the effect on pregnancy outcome. J Nutr 133,1554S-1556S.
15. Gambling L, Anderson HS, Czopek A, Wojciak R, Krejpcio Z and McArdle JH (2004) Effect of timing of iron supplementation on maternal and neonatal growth and iron status of iron-deficient pregnant rats. J Physiol 156,195-203.
16. Georgieff MK, Wobken JK, Welle J, Burdo JR and Connor JR (2000) Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta 21,799-804.
17. Griffiths WJ, Sly WS and Cox TM (2001) Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis. Gastroenterology 120,1420-1429.
18. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL and Hediger MA (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 288,482-488.
19. Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC and Hediger MA (2001) Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett 509,309-316.
20. Harding R (1994) Development of the respiratory system. In Thorburn GD and Harding R (eds) Textbook of Fetal Physiology. Oxford University Press, Oxford, UK, pp 140-167.
21. Hubert N and Hentze MW (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function. Proc Natl Acad Sci USA 99,12345-12350.
22. Koch RO, Zoller H, Theuri I, Obrist P, Egg G, Strohmayer W, Vogel W and Weiss G (2003) Distribution of DMT 1 within the human glandular system Histol Histopathol 18,1095-1101.
23. Leazer TM, Liu Y and Klaassen CD (2002) Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol Appl Pharmacol 185,18-24.
24. Lee PL, Gelbart T, West C, Halloran C and Beutler E (1998) The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis 24,199-215.
25. Levy JE, Montross LK, Cohen DE, Fleming MD and Andrews NC (1999) The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 94,9-11.
26. Okubo M, Yamada K, Hosoyamada M, Shibasaki T and Endou H (2003) Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes. Toxicol Appl Pharmacol 187,162-167.
27. Park JD, Cherrington NJ and Klaassen CD (2002) Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 68,288-294.
28. Roth JA and Garrick MD (2003) Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol 66,1-13.
29. Tabuchi M, Tanaka N, Nishida-Kitayama J, Ohno H and Kishi F (2002) Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol Biol Cell 13,4371-4387.
30. Tallkvist J, Bowlus CL and Lonnerdal B (2001) DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett 122,171-177.
31. Tallkvist J, Bowlus CL and Lonnerdal B (2003) Effect of iron treatment on nickel absorption and gene expression of the divalent metal transporter (DMT1) by human intestinal Caco-2 cells. Pharmacol Toxicol 92,121-124.
32. Tchernitchko D, Bourgeois M, Martin ME and Beaumont C (2002) Expression of the two mRNA isoforms of the iron transporter Nrmap2/DMT1 in mice and function of the iron responsive element. Biochem J 363,449-455.