Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH

Journal of Medicinal Chemistry

Volumn 48, Issue 23, 2005, Pages 7468-7476

  Benkovic, Stephen J ^a   Baker, Stephen J ^a,b   Alley, M R K ^b   Woo, Youn Hi ^a   Zhang, Yong Kang ^b   Akama, Tsutomu ^b   Mao, Weimin ^b   Baboval, Justin ^a   Rajagopalan, P T Ravi ^a,d   Wall, Mark ^a,e   Kahng, Lyn Sue ^c,f   Tavassoli, Ali ^a   Shapiro, Lucy ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c STANFORD UNIVERSITY   (United States)

^d CELERA   (United States)

^e JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CYANOPHENYL)VINYL BORINIC ACID 8 HYDROXYQUINOLINE ESTER; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BENZENE DERIVATIVE; BIS(3 CHLOROPHENYL)BORINIC ACID 8 HYDROXYQUINOLINE ESTER; BIS(4 CHLOROPHENYL)BORINIC ACID 8 HYDROXYQUINALDINE ESTER; BIS(4 CHLOROPHENYL)BORINIC ACID 8 HYDROXYQUINOLINE ESTER; BORINIC ACID DERIVATIVE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE CCRM; DNA METHYLTRANSFERASE MENH; ERYTHROMYCIN; ESTER DERIVATIVE; GENTAMICIN; MENAQUINONE; NITRILE; QUINALDINE DERIVATIVE; QUINOLINOL DERIVATIVE; STREPTOMYCIN; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ALPHAPROTEOBACTERIA; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CAULOBACTER CRESCENTUS; CONTROLLED STUDY; DRUG SCREENING; ENZYME ASSAY; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BORINIC ACIDS; CAULOBACTER CRESCENTUS; DNA MODIFICATION METHYLASES; ESTERS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; KINETICS; MICROBIAL SENSITIVITY TESTS; PROTEOBACTERIA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28544438660     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050676a     Document Type: Article

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