Immunopathogenesis of psoriasis: Recent insights on the role of adaptive and innate immunity

Journal of Autoimmunity

Volumn 25, Issue SUPPL., 2005, Pages 69-73

  Bachelez, Hervé ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Keratinocyte; Psoriasis; T lymphocyte; TNF

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; EFALIZUMAB; ETANERCEPT; FC RECEPTOR; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; OKT 3; PROTEIN P40; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ANTIBODY;

AMINO ACID SUBSTITUTION; ANTIGEN PRESENTING CELL; CELL CULTURE; CELL INFILTRATION; CELL PROLIFERATION; CLINICAL TRIAL; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; GENETIC ENGINEERING; GENETIC RECOMBINATION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; INNATE IMMUNITY; KERATINOCYTE; MEMORY CELL; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; PSORIATIC ARTHRITIS; REVIEW; T LYMPHOCYTE; TH1 CELL; TRANSGENIC ANIMAL;

ANIMALS; CYTOKINES; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; IMMUNOTHERAPY; INTERLEUKIN-12; PSORIASIS; T-LYMPHOCYTES;

EID: 28444493712     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.09.025     Document Type: Review

References (40)

1. B.S. Baker, and L. Fry The immunology of psoriasis Br J Dermatol 126 1992 1 9
2. Z. Bata-Csorgo, C. Hammerberg, J.J. Voorhees, and K.D. Cooper Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes J Clin Invest 95 1995 317 327
3. F.O. Nestle, L.A. Turka, and B.J. Nickoloff Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines J Clin Invest 94 1994 202 209
4. T. Wrone-Smith, and B.J. Nickoloff Dermal injection of immunocytes induces psoriasis J Clin Invest 98 1996 1878 1887
5. B.J. Nickoloff, and T. Wrone-Smith Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis Am J Pathol 155 1999 145 158
6. V.M. Heydendael, P.I. Spuls, B.C. Opmeer, C.A. de Borgie, J.B. Reitsma, and W.F. Goldschmidt Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis N Engl J Med 349 2003 658 665
7. H. Bachelez, B. Flageul, L. Dubertret, S. Fraitag, R. Grossman, and N. Brousse Treatment of recalcitrant plaque psoriasis with a humanized non-depleting antibody to CD4 J Autoimmun 11 1998 53 62
8. C.N. Ellis, G.G. Krueger, and Alefacept Clinical Study Group Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes N Engl J Med 345 2001 248 255
9. M. Lebwohl, S.K. Tyring, T.K. Hamilton, D. Toth, S. Glazer, and N.H. Tawfik A novel targeted T-cell modulator, efalizumab, for plaque psoriasis N Engl J Med 349 2003 2004 2013
10. A. Menssen, P. Trommler, S. Vollmer, D. Schendel, E. Albert, and L. Gürtler Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris J Immunol 155 1995 4078 4083
11. P. Moss, P. Charmley, E. Mulvihill, S. Ziegler, G.J. Raugi, and D. Kern The repertoire of T cell antigen receptor beta-chain variable regions associated with psoriasis vulgaris J Invest Dermatol 109 1997 14 19
12. M.A. Vekony, J.E. Holder, A.J. Lee, C. Horrocks, I.C. Eperon, and R.D.R. Camp Selective amplification of T-cell receptor variable region species is demonstrable but not essential in early lesions of psoriasis vulgaris: analysis by anchored polymerase chain reaction and hypervariable region size spectratyping J Invest Dermatol 109 1997 5 13
13. S. Vollmer, A. Menssen, and J.C. Prinz Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris J Invest Dermatol 117 2001 1296 1301
14. J.C. Prinz, S. Vollmer, W.H. Boehncke, A. Menssen, I. Laisney, and P. Trommler Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris Eur J Immunol 29 1999 3360 3368
15. D.Y. Leung, J.B. Travers, R. Giorno, D.A. Norris, R. Skinner, and J. Aelion Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis J Clin Invest 96 1995 2106 2112
16. J.C. Chang, L.R. Smith, K.J. Froning, B.J. Schwabe, J.A. Laxer, and L.L. Cralli CD8+ T cells in psoriatic lesions preferentially use T-cell receptor Vβ 3 and/or Vβ 13.1 genes Proc Natl Acad Sci USA 91 1994 9282 9286
17. J. Badger HIV and psoriasis Clin Rev Allergy Immunol 14 1996 417 431
18. M.A. Munoz-Perez, A. Rodriguez-Pichardo, F. Camacho, and M.A. Colmenero Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse Br J Dermatol 139 1998 33 39
19. O. Boyman, H.P. Hefti, C. Conrad, B.J. Nickoloff, M. Suter, and F.O. Nestle Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-a J Exp Med 199 2004 731 736
20. B.J. Nickoloff, and F.O. Nestle Recent insights into the pathogenesis of psoriasis provide new therapeutic opportunities J Clin Invest 113 2004 1664 1675
21. S. Sakaguchi Foxp3-expressing CD25+CD4+regulatory T cells in immunological tolerance to self and non-self Nat Immunol 6 2005 345 352
22. P.J. Coffer, and B.M.T. Burgering Forkhead-box transcription factors and their role in the immune system Nat Rev Immunol 4 2004 889 899
23. D.S. Nieves, R. Phipps, S.J. Pollock, H.D. Ochs, Q. Zhu, and G.A. Scott Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome Arch Dermatol 140 2004 466 472
24. M. Viguier, F. Lemaitre, O. Verola, M.S. Cho, G. Gorochov, and L. Dubertret Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells J Immunol 173 2004 1444 1453
25. H. Sugiyama, R. Gyulai, E. Toichi, E. Garaczi, S. Shimada, and S.R. Stevens Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation J Immunol 174 2005 164 173
26. M.R. Ehrenstein, J.G. Evans, A. Singh, S. Moore, G. Warnes, and D.A. Isenberg Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy J Exp Med 200 2004 277 285
27. K.C. Herold, J.B. Burton, F. Francois, E. Poumian-Ruiz, M. Glandt, and J.A. Bluestone Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala) J Clin Invest 111 2003 409 418
28. T.O. Utset, J.A. Auger, D. Peace, R.A. Zivin, D. Xu, and L. Jolliffe Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial J Rheumatol 29 2002 1907 1913
29. F. Brombacher, R.A. Kastelein, and G. Aber Novel IL-12 family members shed light on the orchestration of Th1 responses Trends Immunol 24 2003 207 212
30. T. Kopp, P. Lenz, C. Bello-Fernandez, R.A. Kastelein, T.S. Kupper, and G. Stingl IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity J Immunol 170 2003 5438 5444
31. E. Lee, W.L. Trepicchio, J.L. Oestreicher, D. Pittman, F. Wang, and F. Chamian Increased expression of interleukin-23 p19 and p40 in lesional skin of patients with psoriasis J Exp Med 199 2004 125 130
32. C.L. Kaufman, N. Aria, E. Toichi, T.S. McCormick, K.D. Cooper, and A.B. Gottlieb A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis J Invest Dermatol 123 2004 1037 1044
33. M.P. Schön Animal models of psoriasis - What can we learn from them? J Invest Dermatol 112 1999 405 410
34. S. Sano, K.S. Chan, S. Carbajal, J. Clifford, M. Peavey, and K. Kiguchi Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model Nat Med 11 2005 43 49
35. K. Asadullah, W. Sterry, K. Stephanek, D. Jasulatis, M. Leupold, and H. Audring IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach J Clin Invest 101 1998 783 794
36. K. Ghoreschi, P. Thomas, S. Breit, M. Dugas, R. Mailhammer, and W. van Eden Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease Nat Med 9 2003 40 46
37. U. Chaudhari, P. Romano, L.D. Mulcahy, L.T. Dooley, D.G. Baker, and A.B. Gottlieb Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial Lancet 357 2001 1842 1847
38. C.L. Leonardi, J.L. Powers, R.T. Matheson, B.S. Goffe, R. Zitnik, and A. Wang Etanercept as monotherapy in patients with psoriasis N Engl J Med 349 2003 2014 2022
39. C. Helms, L. Cao, J.G. Krueger, E.M. Wijsman, F. Chamian, and D. Gordon A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis Nat Genet 35 2003 349 356
40. B. Beutler Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263