Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats

British Journal of Pharmacology

Volumn 146, Issue 7, 2005, Pages 935-941

  Nguyen, Tien Thuy ^a   White, Paul James ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Angiotensin II; Antisense; Cardiovascular; Insulin like growth factor I; Insulin like growth factor I receptor

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; NORADRENALIN; SOMATOMEDIN C RECEPTOR;

ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HEART LEFT VENTRICLE; HEART RATE; HEART WEIGHT; IMMUNOREACTIVITY; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; FEMALE; NOREPINEPHRINE; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, IGF TYPE 1;

EID: 28444466235     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706378     Document Type: Article

References (38)

1. BORNFELDT, K.E., ARNQVIST, H.J. & NORSTEDT, G. (1990). Regulation of insulin-like growth factor-I gene expression by growth factors in cultured vascular smooth muscle cells. J. Endocrinol., 125, 381-386.
2. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem., 72, 248-254.
3. BRINK, M., CHRAST, J., PRICE, S.R., MITCH, W.E. & DELAFONTAINE, P. (1999). Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake. Hypertension, 34, 1053-1059.
4. CHEN, Y., BORNFELDT, K.E., ARNER, A., JENNISCHE, E., MALMQVIST, U., UVELIUS, B. & ARNQVIST, H.J. (1994). Increase in insulin-like growth factor I in hypertrophying smooth muscle. Am. J. Physiol., 266, E224-E229.
5. CITTADINI, A., STROMER, H., KATZ, S.E., CLARK, R., MOSES, A.C., MORGAN, J.P. & DOUGLAS, P.S. (1996). Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. Circulation, 93, 800-809.
6. DECKER, R.S., COOK, M.G., BEHNKE-BARCLAY, M. & DECKER, M.L. (1995). Some growth factors stimulate cultured adult rabbit ventricular myocyte hypertrophy in the absence of mechanical loading. Circ. Res., 77, 544-555.
7. DELAFONTAINE, P. (1995). Insulin-like growth factor I and its binding proteins in the cardiovascular system. Cardiovasc. Res., 30, 825-834.
8. DELAFONTAINE, P., LOU, H. & ALEXANDER, R.W. (1991). Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells. Hypertension, 18, 742-747.
9. DONOHUE, T.J., DWORKIN, L.D., MA, J., LANGO, M.N. & CATANESE, V.M. (1997). Antihypertensive agents that limit ventricular hypertrophy inhibit cardiac expression of insulin-like growth factor-I. J. Investig. Med., 45, 584-591.
10. DOSTAL, D.E. & BAKER, K.M. (1992). Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor. Am. J. Hypertens., 5, 276-280.
11. FRYBURG, D.A. (1996). NG-monomethyl-L-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF-I: possible role of nitric oxide in muscle protein synthesis. J. Clin. Invest., 97, 1319-1328.
12. FULLER, S.J., MYNETT, J.R. & SUGDEN, P.H. (1992). Stimulation of cardiac protein synthesis by insulin-like growth factors. Biochem. J., 282 (Part 1), 85-90.
13. GEENEN, D.L., MALHOTRA, A. & SCHEUER, J. (1993). Angiotensin II increases cardiac protein synthesis in adult rat heart. Am. J. Physiol., 265, H238-H243.
14. GIANNELLA-NETO, D., KAMYAR, A., SHARIFI, B., PIROLA, C.J., KUPFER, J., ROSENFELD, R.G., FORRESTER, J.S. & FAGIN, J.A. (1992). Platelet-derived growth factor isoforms decrease insulin-like growth factor I gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4. Circ. Res., 71, 646-656.
15. GUSTAFSSON, T., ANDERSSON, P., CHEN, Y., MAGNUSSON, J.O. & ARNQVIST, H.J. (1999). Interaction of angiotensin II and the insulin-like growth factor system in vascular smooth muscle cells. Am. J. Physiol., 277, H499-H507.
16. HASDAI, D., RIZZA, R.A., HOLMES JR, D.R., RICHARDSON, D.M., COHEN, P. & LERMAN, A. (1998). Insulin and insulin-like growth factor-I cause coronary vasorelaxation in vitro. Hypertension, 32, 228-234.
17. HU, Z.W., SHI, X.Y. & HOFFMAN, B.B. (1996). Insulin and insulin-like growth factor I differentially induce alpha1-adrenergic receptor subtype expression in rat vascular smooth muscle cells. J. Clin. Invest., 98, 1826-1834.
18. INISHI, Y., OKUDA, T., ARAKAWA, T. & KUROKAWA, K. (1994). Insulin attenuates intracellular calcium responses and cell contraction caused by vasoactive agents. Kidney Int., 45, 1318-1325.
19. ITO, H., HIROE, M., HIRATA, Y., TSUJINO, M., ADACHI, S., SHICHIRI, M., KOIKE, A., NOGAMI, A. & MARUMO, F. (1993). Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation, 87, 1715-1721.
20. KAISTURA, J., FIORDALISO, F., ANDREOLI, A.M., LI, B., CHIMENTI, S., MEDOW, M.S., LIMANA, F., NADAL-GINARD, B., LERI, A. & ANVERSA, P. (2001). IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes, 50, 1414-1424.
21. KAMIDE, K., HORI, M.T., ZHU, J.H., TAKAGAWA, Y., BARRETT, J.D., EGGENA, P. & TUCK, M.L. (2000). Insulin and insulin-like growth factor-I promotes angiotensinogen production and growth in vascular smooth muscle cells. J. Hypertens., 18, 1051-1056.
22. KHAN, A.S., SANE, D.C., WANNENBURG, T. & SONNTAG, W.E. (2002). Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc. Res., 54, 25-35.
23. KINUGAWA, S., TSUTSUI, H., IDE, T., NAKAMURA, R., ARIMURA, K., EGASHIRA, K. & TAKESHITA, A. (1999). Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes. Cardiovasc. Res., 43, 157-164.
24. LEMBO, G., ROCKMAN, H.A., HUNTER, J.J., STEINMETZ, H., KOCH, W.J., MA, L., PRINZ, M.P., ROSS JR, J., CHIEN, K.R. & POWELL-BRAXTON, L. (1996). Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J. Clin. Invest., 98, 2648-2655.
25. LEONETTI, C., D'AGNANO, I., LOZUPONE, F., VALENTINI, A., GEISER, T., ZON, G., CALABRETTA, B., CITRO, G.C. & ZUPI, G. (1996). Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and in mice. J. Natl. Cancer Inst., 88, 419-429.
26. MULLER, C., REDDERT, A., WASSMANN, S., STREHLOW, K., BOHM, M. & NICKENIG, G. (2000). Insulin-like growth factor induces up-regulation of AT(1)-receptor gene expression in vascular smooth muscle cells. J. Renin Angiotensin Aldosterone Syst., 1, 273-277.
27. NIEBAUER, J., PFLAUM, C.D., CLARK, A.L., STRASBURGER, C.J., HOOPER, J., POOLE-WILSON, P.A., COATS, A.J. & ANKER, S.D. (1998). Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation. J. Am. Coll Cardiol., 32, 393-397.
28. OLTMAN, C.L., KANE, N.L., GUTTERMAN, D.D., BAR, R.S. & DELLSPERGER, K.C. (2000). Mechanism of coronary vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. Am. J. Physiol. Endocrinol. Metab., 279, E176-E181.
29. PAULIKS, L.B., COLE, K.E. & MERGNER, W.J. (1999). Increased insulin-like growth factor-1 protein in human left ventricular hypertrophy. Exp. Mol. Pathol., 66, 53-58.
30. PHILLIPS, M.I. (2002). Gene therapy for hypertension: the preclinical data. Methods Enzymol., 346, 3-13.
31. REISS, K., CHENG, W., FERBER, A., KAJSTURA, J., LI, P., LI, B., OLIVETTI, G, HOMCY, C.J., BASERGA, R. & ANVERSA, P. (1996). Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc. Natl. Acad. Sci. U.S.A., 93, 8630-8635.
32. SALATINO, M., SCHILLACI, R., PROIETTI, C.J., CARNEVALE, R., FRAHM, I., MOLINOLO, A.A., IRIBARREN, A., CHARREAU, E.H. & ELIZALDE, P.V. (2004). Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogens, 23, 5161-5174.
33. VECCHIONE, C., COLELLA, S., FRATTA, L., GENTILE, M.T., SELVETELLA, G., FRATI, G., TRIMARCO, B. & LEMBO, G. (2001). Impaired insulin-like growth factor I vasorelaxant effects in hypertension. Hypertension, 37, 1480-1485.
34. WALSH, M.F., BARAZI, M., PETE, G., MUNIYAPPA, R., DUNBAR, J.C. & SOWERS, J.R. (1996). Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. Endocrinology, 137, 1798-1803.
35. WRAIGHT, C.J., WHITE, P.J., MCKEAN, S.C., FOGARTY, R.D., VENABLES, D.J., LIEPE, I.J., EDMONDSON, S.R. & WERTHER, G.A. (2000). Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides. Nat. Biotechnol., 18, 521-526.
36. YASUMARU, M., TSUJI, S., TSUJII, M., IRIE, T., KOMORI, M., KIMURA, A., NISHIDA, T., KAKIUCHI, Y., KAWAI, N., MURATA, H., HORIMOTO, M., SASAKl, Y., HAYASHI, N., KAWANO, S. & HORI, M. (2003). Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. Cancer Res., 63, 6726-6734.
37. ZHANG, Y.C., BUI, J.D., SHEN, L. & PHILLIPS, M.I. (2000). Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation, 101, 682-688.
38. ZHAO, G., SUTLIFF, R.L., WEBER, C.S., WANG, J., LARENZ, J., PAUL, R.J. & FAGIN, J.A. (2001). Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility. Endocrinology, 142, 623-632.