Current advances in xenotransplantation

Hepatobiliary and Pancreatic Diseases International

Volumn 4, Issue 4, 2005, Pages 490-494

  Cox, Ashley ^a   Zhong, Robert ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Cloning; Pig; Transgenic; Xenotransplantation; Zoonosis

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ANTIBODY; CD40 LIGAND MONOCLONAL ANTIBODY; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DECAY ACCELERATING FACTOR; EPITOPE; FIBRINOGEN; GALACTOSE; GAS 914; HIRUDIN; IMMUNOSUPPRESSIVE AGENT; MEMBRANE COFACTOR PROTEIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEX 1285; RAPAMYCIN; REGULATOR PROTEIN; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY; TISSUE FACTOR PATHWAY INHIBITOR; UNCLASSIFIED DRUG;

BABOON; BLOOD CLOTTING; DISEASE MODEL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; KNOCKOUT GENE; MEDICAL RESEARCH; NONHUMAN; RESEARCH ETHICS; RETROVIRUS; REVIEW; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION; ZOONOSIS;

ANIMALS; BLOOD COAGULATION; GENE DELETION; GRAFT REJECTION; HUMANS; SWINE; TISSUE DONORS; TRANSPLANTATION, HETEROLOGOUS; ZOONOSES;

EID: 28444453721     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Ogata K, Platt JL. Cardiac xenotransplantation: future and limitations. Cardiology 2004;101:144-155.
2. Delmonico FL, Sheehy E, Marks WH, Baliga P, McGowan JJ, Magee JC. Organ donation and utilization in the united states, 2004. An J Transplant 2005;5(4pt2):862-873.
3. Platt JL. The immunological barriers to xenotransplantation. Crit Rew Immunol 1996;16:331-358.
4. Hardy JD, Chavez CM, Kurrus FD, Neely WA, Eraslan S, Turner MD, et al. Heart transplantation in man: developmental studies and report of a case. JAMA 1964;188:1132-1140.
5. Sykes M, d'Apice A, Sandrin M. Position paper of the Ethics Committee of the International Xenotransplantation Association. Transplantation 2004;78:1101-1107.
6. Zhong R, Tucker Z, Wall W, Grant D, Quan D, Garcia B, et al. The long-term survival of baboon-to-monkey kidney and liver xenografts. Xenotransplantation 2003;10:398-409.
7. Dorling A. Clinical xenotransplantation: Pigs might fly? Am J Transplant 2002;2:695-700.
8. Diamond LE, Quinn CM, Martin MJ, Lawson J, Platt JL, Logan JS. A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 2001; 71:132-142.
9. Cozzi E, Tucker AW, Langford GA, Pino-Chavez G, Wright L, O'Connell MJ, et al. Characterization of pigs transgenic for human decay-accelerating factor. Transplantation 1997;64:1383-1392.
10. Bhatti FNK, Schmoeckel M, Zaidi A, Cozzi E, Chavez G, Goddard M, et al. Three-month survival of hDAF transgenic pig hearts transplanted into primates. Transplant Proc 1999; 31:958.
11. Good AH, Cooper DK, Malcolm AJ, Ippolito RM, Koren E, Neethling F, et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992;24: 559-562.
12. Zhong R, Luo Y, Yang H, Garcia B, Ghanekar A, Luke P, et al. Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of GAS914, a polymeric form of αGal. Transplantation 2003;75:10-19.
13. Ghanekar A, LaJoie G, Luo Y, Yang H, Choi J, Garcia B, et al. Improvement in rejection of human accelerating factor transgenic pig-to-primate renal xenografts with administration of rabbit antithymocyte serum. Transplantation 2002;74:28-35.
14. Kuwaki K, Knosalla C, Dor FJ, Gollackner B, Tseng YL, Houser S, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regime. Am J Transplant 2004;4: 363-372.
15. McGregor CGA, Teotia SS, Byrne GW, Michaels MG, Risdahl JM, Schirmer JM, et al. Cardiac xenotransplantation: progress toward the clinic. Transplantation 2004;78:1569-1575.
16. Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, et al. Production of α-1, 3-galactosyltrasferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. PNAS 2004;101:7335-7340.
17. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, et al. Heart transplantation in baboons using α-1, 3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005;11:29-31.
18. Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of α-1, 3-galactosyl-transferase knock out donors and the cotransplantation of vascularized thymic tissue. Nature 2005;11:32-34.
19. Ierino FL, Kozlowski T, Siegel JB, Shimizu A, Colvin RB, Banerjee PT, et al. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation 1998;66:1439-1450.
20. Chen D, Weber M, McVey JH, Kemball-Cook G, Tuddenham EGD, Lechler RI, et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004;4:1958-1963.
21. Ghanekar A, Mendicino, M, Liu H, He W, Liu M, Zhong R, et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol 2004;172:5693-5701.
22. Patience C, Stoye J. Infectious risk of clinical xenotransplantation. Curr Opin Organ Transplant 2004;9:176-180.
23. Takeuchi Y, Patience C, Magre S, Weiss RA, Banerjee PT, Le Tissier P, et al. Host range and interference studies of three classes of pig endogenous retrovirus. J Virol 1998;72:9986-9991.
24. Scobie L, Taylor S, Wood JC, Suhng KM, Quinn G, Meikle S, et al. Absence of replication-competent human-tropic porcine endogenous retroviruses in the germ line DNA of inbred miniature swine. J Virol 2004;78:2502-2509.
25. Wood JC, Quinn G, Suling KM, Oldmixon BA, Van Tine BA, Cina R, et al. Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature swine. J Virol 2004;78:2494-2501.
26. Rother RP, Squinto SP. The alpha-galactosyl epitope: a sugar coating that makes viruses and cells unpalatable. Cell 1996; 86:185-188.
27. Quinn G, Wood JC, Ryan DJ, Suling KM, Moran KM, Kolber-Simonds DL, et al. Porcine endogenous retrovirus transmission characteristics of galactose α1, 3-Galactose-deficient pig cells. J Virol 2004;78:5805-5811.
28. Simon AR, Templin C, Schroder C, Laaff C, Tessmann R, Winkler ME, et al. No evidence for productive PERV infection of baboon cells in in vivo infection model. Ann Transplant 2003;8:24-34.
29. Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissues. Science 1999;285:1236-1241.
30. Ogle B, Cascalho M, Platt JL. Fusion of approaches to the treatment of organ failure. Am J Transplant 2004;4:74-77.