Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid

Virchows Archiv

Volumn 447, Issue 6, 2005, Pages 996-999

  Sato, Katsuaki ^a   Ueda, Yoshimichi ^a   Ueno, Keiichi ^a   Okamoto, Kazuya ^a   Iizuka, Hideaki ^a   Katsuda, Shogo ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Hepatocellular carcinoma; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Valproic acid

Indexed keywords

ALCOHOL; VALPROIC ACID;

ADULT; ALCOHOL ABSTINENCE; ARTICLE; AUTOPSY; CASE REPORT; DEATH; DIABETES MELLITUS; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; HYPERLIPIDEMIA; INFLAMMATION; LABORATORY TEST; LIVER; LIVER CELL CARCINOMA; LIVER FAILURE; MALE; MULTIPLE CANCER; NONALCOHOLIC FATTY LIVER; OBESITY; PNEUMONIA; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE;

ANTICONVULSANTS; CARCINOMA, HEPATOCELLULAR; FATTY LIVER; HEPATITIS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; SEIZURES; SUBARACHNOID HEMORRHAGE; TIME FACTORS; VALPROIC ACID;

EID: 28344452944     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-0042-z     Document Type: Article

References (23)

1. Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231
2. Biton V, Mirza W, Montouris G, Vuong A, Hammer AE, Barrett PS (2001) Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology 56:172-177
3. Brunt EM (2004) Nonalcoholic steatohepatitis. Semin Liver Dis 24:3-20
4. Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, De Paolis P, Capussotti L, Salizzoni M, Rizzetto M (2002) Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123:134-140
5. Caldwell SH, Crespo DM, Kang HS, Al-Osaimi AM (2004) Obesity and hepatocellular carcinoma. Gastroenterology 127:S97-S103
6. Cotrim HP, Parana R, Braga E, Lyra L (2000) Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history? Am J Gastroenterol 95:3018-3019
7. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860-867
8. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ (2001) Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21:17-26
9. Farrell GC (2002) Drugs and steatohepatitis. Semin Liver Dis 22:185-194
10. Göttlicher M, Minucci S, Zhu P, Krämer OH, Schimpf A, Giavara S, Sleeman JP, Lo Coco F, Nervi C, Pelicci PG, Heinzel T (2001) Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20:6969-6978
11. Marnett LJ (2000) Oxyradicals and DNA damage. Carcinogenesis 21:361-370
12. Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS (2002) NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 36:1349-1354
13. Mori S, Yamasaki T, Sakaida I, Takami T, Sakaguchi E, Kimura T, Kurokawa F, Maeyama S, Okita K (2004) Hepatocellular carcinoma with nonalcoholic steatohepatitis. J Gastroenterol 39:391-396
14. Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37:1202-1219 (Erratum in: Hepatology 2003;38:536)
15. Ong J, Younossi ZM, Reddy V, Price LL, Gramlich T, Mayes J, Boparai N (2001) Cryptogenic cirrhosis and posttransplantation nonalcoholic fatty liver disease. Liver Transpl 7:797-801
16. Orikasa H, Ohyama R, Tsuka N, Eyden BP, Yamazaki K (2001) Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholic steatohepatitis in a patient with diabetes mellitus. J Submicrosc Cytol Pathol 33:195-200
17. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW (1990) The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11:74-80
18. Schafer DF, Sorrell MF (1999) Hepatocellular carcinoma. Lancet 353:1253-1257
19. Shimada M, Hashimoto E, Taniai M, Hasegawa K, Okuda H, Hayashi N, Takasaki K, Ludwig J (2002) Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. J Hepatol 37:154-160
20. Singh G, Driever PH, Sander JW (2005) Cancer risk in people with epilepsy: the role of antiepileptic drugs. Brain 128:7-17
21. Soga M, Kishimoto Y, Kawamura Y, Inagaki S, Makino S, Saibara T (2003) Spontaneous development of hepatocellular carcinomas in the FLS mice with hereditary fatty liver. Cancer Lett 196:43-48
22. Xu Z, Chen L, Leung L, Yen TS, Lee C, Chan JY (2005) Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A 102:4120-4125
23. Zen Y, Katayanagi K, Tsuneyama K, Harada K, Araki I, Nakanuma Y (2001) Hepatocellular carcinoma arising in non-alcoholic steatohepatitis. Pathol Int 51:127-131