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Volumn 24, Issue 1, 2006, Pages 36-44

Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis

Author keywords

Immunogenicity; Multivalent liposomes; Neisseria meningitides; Recombinant PorA

Indexed keywords

LIPOSOME; OUTER MEMBRANE PROTEIN; PORIN A; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 28344436617     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.07.056     Document Type: Article
Times cited : (30)

References (49)
  • 1
    • 0036739777 scopus 로고    scopus 로고
    • Impact of meningococcal C conjugate vaccine in the UK
    • P. Balmer, R. Borrow, and E. Miller Impact of meningococcal C conjugate vaccine in the UK J Med Microbiol 51 2002 717 722
    • (2002) J Med Microbiol , vol.51 , pp. 717-722
    • Balmer, P.1    Borrow, R.2    Miller, E.3
  • 2
    • 0028794029 scopus 로고
    • Antibodies to meningococcal class 1 outer-membrane protein and its variable regions in patients with systemic meningococcal disease
    • I. Idanpaan-Heikkila, E.A. Hoiby, P. Chattopadhyay, U. Airaksinen, T.M. Michaelsen, and E. Wedege Antibodies to meningococcal class 1 outer-membrane protein and its variable regions in patients with systemic meningococcal disease J Med Microbiol 43 1995 335 343
    • (1995) J Med Microbiol , vol.43 , pp. 335-343
    • Idanpaan-Heikkila, I.1    Hoiby, E.A.2    Chattopadhyay, P.3    Airaksinen, U.4    Michaelsen, T.M.5    Wedege, E.6
  • 3
    • 0020518256 scopus 로고
    • Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis
    • J. Finne, M. Leinonen, and P.H. Makela Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis Lancet ii 1983 355 357
    • (1983) Lancet , vol.2 , pp. 355-357
    • Finne, J.1    Leinonen, M.2    Makela, P.H.3
  • 4
    • 0022648523 scopus 로고
    • Human antibody response to a group B serotype 2a meningococcal vaccine determined by immunoblotting
    • E. Wedege, and L.O. Froholm Human antibody response to a group B serotype 2a meningococcal vaccine determined by immunoblotting Infect Immun 51 1986 571 578
    • (1986) Infect Immun , vol.51 , pp. 571-578
    • Wedege, E.1    Froholm, L.O.2
  • 5
    • 0028167962 scopus 로고
    • Immune response of Brazilian children to a Neisseria meningitidis serogroup B outer membrane protein vaccine: Comparison with efficacy
    • L.G. Milagres, S.R. Ramos, C.T. Sacchi, C.E.A. Melles, V.S.D. Vieira, and H. Sato Immune response of Brazilian children to a Neisseria meningitidis serogroup B outer membrane protein vaccine: comparison with efficacy Infect Immun 62 1994 4419 4424
    • (1994) Infect Immun , vol.62 , pp. 4419-4424
    • Milagres, L.G.1    Ramos, S.R.2    Sacchi, C.T.3    Melles, C.E.A.4    Vieira, V.S.D.5    Sato, H.6
  • 6
    • 0028788521 scopus 로고
    • Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine
    • E. Rosenqvist, E.A. Hoiby, E. Wedege, K. Bryn, J. Kolberg, and A. Klem Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine Infect Immun 63 1995 4642 4652
    • (1995) Infect Immun , vol.63 , pp. 4642-4652
    • Rosenqvist, E.1    Hoiby, E.A.2    Wedege, E.3    Bryn, K.4    Kolberg, J.5    Klem, A.6
  • 7
    • 0030002662 scopus 로고    scopus 로고
    • Specificity of human bactericidal antibodies against PorA P1.7, 16 induced with a hexavalent meningococcal outer membrane vesicle vaccine
    • E.M. Rouppe van der Voort, P. van der Ley, J. van der Biezen, S. George, O. Tunnela, and H. van Dijken Specificity of human bactericidal antibodies against PorA P1.7, 16 induced with a hexavalent meningococcal outer membrane vesicle vaccine Infect Immun 64 1996 2745 2751
    • (1996) Infect Immun , vol.64 , pp. 2745-2751
    • Rouppe Van Der Voort, E.M.1    Van Der Ley, P.2    Van Der Biezen, J.3    George, S.4    Tunnela, O.5    Van Dijken, H.6
  • 9
    • 0027502745 scopus 로고
    • Class 1 outer membrane protein of Neisseria meningitidis: Epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology
    • B.T. McGuinness, P.R. Lambden, and J.E. Heckels Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology Mol Microbiol 7 1993 505 514
    • (1993) Mol Microbiol , vol.7 , pp. 505-514
    • McGuinness, B.T.1    Lambden, P.R.2    Heckels, J.E.3
  • 10
    • 0025989151 scopus 로고
    • Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway
    • G. Bjune, E.A. Hoiby, J.K. Gronnesby, O. Arnesen, J. Holstfredriksen, and A. Halstensen Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway Lancet 338 1991 1093 1096
    • (1991) Lancet , vol.338 , pp. 1093-1096
    • Bjune, G.1    Hoiby, E.A.2    Gronnesby, J.K.3    Arnesen, O.4    Holstfredriksen, J.5    Halstensen, A.6
  • 11
    • 0029069384 scopus 로고
    • Efficacy, safety, and immunogenicity of a meningococcal group B (15 P1.3) outer membrane protein vaccine in Iquique, Chile
    • J. Boslego, J. Garcia, C. Cruz, W. Zollinger, B. Brandt, and S. Ruiz Efficacy, safety, and immunogenicity of a meningococcal group B (15 P1.3) outer membrane protein vaccine in Iquique, Chile Vaccine 13 1995 821 829
    • (1995) Vaccine , vol.13 , pp. 821-829
    • Boslego, J.1    Garcia, J.2    Cruz, C.3    Zollinger, W.4    Brandt, B.5    Ruiz, S.6
  • 13
    • 17344371261 scopus 로고    scopus 로고
    • Immunogenicity of two efficacious outer membrane protein-based serogroup B meningococcal vaccines among young adults in Iceland
    • B.A. Perkins, K. Jonsdottir, H. Briem, E. Griffiths, B.D. Plikaytis, and E.A. Hoiby Immunogenicity of two efficacious outer membrane protein-based serogroup B meningococcal vaccines among young adults in Iceland J Infect Dis 177 1998 683 691
    • (1998) J Infect Dis , vol.177 , pp. 683-691
    • Perkins, B.A.1    Jonsdottir, K.2    Briem, H.3    Griffiths, E.4    Plikaytis, B.D.5    Hoiby, E.A.6
  • 14
    • 0029145669 scopus 로고
    • The antimeningococcal vaccine VA-MENGOC-BC induced poor serum and salivary antibody-response in young Brazilian children
    • S.B. Carbonare, C. Arslanian, M.M. Silva, C.K. Farhat, and M.S. Carneirosampaio The antimeningococcal vaccine VA-MENGOC-BC induced poor serum and salivary antibody-response in young Brazilian children Pediatr Infect Dis J 14 1995 797 803
    • (1995) Pediatr Infect Dis J , vol.14 , pp. 797-803
    • Carbonare, S.B.1    Arslanian, C.2    Silva, M.M.3    Farhat, C.K.4    Carneirosampaio, M.S.5
  • 15
    • 14844330115 scopus 로고    scopus 로고
    • The New Zealand Meningococcal Vaccine Strategy: A tailor-made vaccine to combat a devastating epidemic
    • K. Sexton, D. Lennon, P. Oster, S. Crengle, D. Martin, and K. Mulholland The New Zealand Meningococcal Vaccine Strategy: a tailor-made vaccine to combat a devastating epidemic NZ Med J 117 2004 U1015
    • (2004) NZ Med J , vol.117 , pp. 1015
    • Sexton, K.1    Lennon, D.2    Oster, P.3    Crengle, S.4    Martin, D.5    Mulholland, K.6
  • 16
    • 20044367291 scopus 로고    scopus 로고
    • From secondary prevention to primary prevention: A unique strategy that gives hope to a country ravaged by meningococcal disease
    • J. O'Hallahan, D. Lennon, P. Oster, R. Lane, S. Reid, and K. Mulholland From secondary prevention to primary prevention: a unique strategy that gives hope to a country ravaged by meningococcal disease Vaccine 23 2005 2197 2201
    • (2005) Vaccine , vol.23 , pp. 2197-2201
    • O'Hallahan, J.1    Lennon, D.2    Oster, P.3    Lane, R.4    Reid, S.5    Mulholland, K.6
  • 17
    • 0028938010 scopus 로고
    • Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine
    • P. van der Ley, J. van der Biezen, and J.T. Poolman Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine Vaccine 13 1995 401 407
    • (1995) Vaccine , vol.13 , pp. 401-407
    • Van Der Ley, P.1    Van Der Biezen, J.2    Poolman, J.T.3
  • 18
    • 0030197578 scopus 로고    scopus 로고
    • Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine
    • I. Claassen, J. Meylis, P. van der Ley, C. Peeters, H. Brons, and J. Robert Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine Vaccine 14 1996 1001 1008
    • (1996) Vaccine , vol.14 , pp. 1001-1008
    • Claassen, I.1    Meylis, J.2    Van Der Ley, P.3    Peeters, C.4    Brons, H.5    Robert, J.6
  • 19
    • 0030197579 scopus 로고    scopus 로고
    • Phase-I clinical-trial with a hexavalent PorA containing meningococcal outer-membrane vesicle vaccine
    • C.M. Peeters, H.C. Rumke, L.C. Sundermann, E.R. Vandervoort, J. Meulenbelt, and M. Schuller Phase-I clinical-trial with a hexavalent PorA containing meningococcal outer-membrane vesicle vaccine Vaccine 14 1996 1009 1015
    • (1996) Vaccine , vol.14 , pp. 1009-1015
    • Peeters, C.M.1    Rumke, H.C.2    Sundermann, L.C.3    Vandervoort, E.R.4    Meulenbelt, J.5    Schuller, M.6
  • 20
    • 0033523057 scopus 로고    scopus 로고
    • Immunogenicity and reactogenicity in UK infants of a novel meningococcal vesicle vaccine containing multiple class 1 (PorA) outer membrane proteins
    • K. Cartwright, R. Morris, H. Rumke, A. Fox, R. Borrow, and N. Begg Immunogenicity and reactogenicity in UK infants of a novel meningococcal vesicle vaccine containing multiple class 1 (PorA) outer membrane proteins Vaccine 17 1999 2612 2619
    • (1999) Vaccine , vol.17 , pp. 2612-2619
    • Cartwright, K.1    Morris, R.2    Rumke, H.3    Fox, A.4    Borrow, R.5    Begg, N.6
  • 21
    • 0037435940 scopus 로고    scopus 로고
    • Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes
    • C. Arigita, G.F.A. Kersten, T. Hazendonk, W.E. Hennink, D.J.A. Crommelin, and W. Jiskoot Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes Vaccine 21 2003 950 960
    • (2003) Vaccine , vol.21 , pp. 950-960
    • Arigita, C.1    Kersten, G.F.A.2    Hazendonk, T.3    Hennink, W.E.4    Crommelin, D.J.A.5    Jiskoot, W.6
  • 22
    • 0031736406 scopus 로고    scopus 로고
    • Immunisation with recombinant class 1 outer membrane protein from Neisseria meningitidis: Influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci
    • M. Christodoulides, J.L. Brooks, E. Rattue, and J.E. Heckels Immunisation with recombinant class 1 outer membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci Microbiology 144 1998 3027 3037
    • (1998) Microbiology , vol.144 , pp. 3027-3037
    • Christodoulides, M.1    Brooks, J.L.2    Rattue, E.3    Heckels, J.E.4
  • 23
    • 1842456039 scopus 로고    scopus 로고
    • Recombinant meningococcal PorA protein, expressed using a vector system with potential for human vaccination, induces a bactericidal immune response
    • H.E. Humphries, J.N. Williams, M. Christodoulides, and J.E. Heckels Recombinant meningococcal PorA protein, expressed using a vector system with potential for human vaccination, induces a bactericidal immune response Vaccine 22 2004 1564 1569
    • (2004) Vaccine , vol.22 , pp. 1564-1569
    • Humphries, H.E.1    Williams, J.N.2    Christodoulides, M.3    Heckels, J.E.4
  • 24
    • 0028791267 scopus 로고
    • The antibody response to a prototype liposome vaccine containing Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis
    • I. Idanpaan-Heikkila, S. Muttilainen, E. Wahlstrom, L. Saarinen, M. Leinonen, and M. Sarvas The antibody response to a prototype liposome vaccine containing Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis Vaccine 13 1995 1501 1508
    • (1995) Vaccine , vol.13 , pp. 1501-1508
    • Idanpaan-Heikkila, I.1    Muttilainen, S.2    Wahlstrom, E.3    Saarinen, L.4    Leinonen, M.5    Sarvas, M.6
  • 26
    • 0029093648 scopus 로고
    • The Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis and reconstituted into phospholipid vesicles elicits antibodies to native P1 epitopes
    • S. Muttilainen, I. Idanpaan-Heikkila, E. Wahlstrom, M. Nurminen, P.H. Makela, and M. Sarvas The Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis and reconstituted into phospholipid vesicles elicits antibodies to native P1 epitopes Microb Pathog 18 1995 423 436
    • (1995) Microb Pathog , vol.18 , pp. 423-436
    • Muttilainen, S.1    Idanpaan-Heikkila, I.2    Wahlstrom, E.3    Nurminen, M.4    Makela, P.H.5    Sarvas, M.6
  • 28
    • 0022445669 scopus 로고
    • Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection
    • C.R. Tinsley, and J.E. Heckels Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection J Gen Microbiol 132 1986 2483 2490
    • (1986) J Gen Microbiol , vol.132 , pp. 2483-2490
    • Tinsley, C.R.1    Heckels, J.E.2
  • 30
    • 0030550722 scopus 로고    scopus 로고
    • Expression of Neisseria meningitidis class 1 porin as a fusion protein in Escherichia coli: The influence of liposomes and adjuvants on the production of a bactericidal immune response
    • S.J. Ward, D.A. Scopes, M. Christodoulides, I.N. Clarke, and J.E. Heckels Expression of Neisseria meningitidis class 1 porin as a fusion protein in Escherichia coli: the influence of liposomes and adjuvants on the production of a bactericidal immune response Microb Pathog 21 1996 499 512
    • (1996) Microb Pathog , vol.21 , pp. 499-512
    • Ward, S.J.1    Scopes, D.A.2    Christodoulides, M.3    Clarke, I.N.4    Heckels, J.E.5
  • 32
    • 0027183620 scopus 로고
    • Immunisation with synthetic peptides containing epitopes of the class 1 outer membrane protein of Neisseria meningitidis: Production of bactericidal antibodies on immunisation with a cyclic peptide
    • M. Christodoulides, B.T. McGuinness, and J.E. Heckels Immunisation with synthetic peptides containing epitopes of the class 1 outer membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunisation with a cyclic peptide J Gen Microbiol 139 1993 1729 1738
    • (1993) J Gen Microbiol , vol.139 , pp. 1729-1738
    • Christodoulides, M.1    McGuinness, B.T.2    Heckels, J.E.3
  • 33
    • 0034072866 scopus 로고    scopus 로고
    • Lack of immunity in university students prior to an outbreak of serogroup C meningococcal infection
    • G.R. Jones, J.N. Williams, M. Christodoulides, K. Jolley, and J.E. Heckels Lack of immunity in university students prior to an outbreak of serogroup C meningococcal infection J Infect Dis 181 2000 1172 1175
    • (2000) J Infect Dis , vol.181 , pp. 1172-1175
    • Jones, G.R.1    Williams, J.N.2    Christodoulides, M.3    Jolley, K.4    Heckels, J.E.5
  • 34
    • 0035010024 scopus 로고    scopus 로고
    • Immunisation with recombinant Opc outer membrane protein from Neisseria meningitidis: Influence of sequence variation and levels of expression on the bactericidal immune response against meningococci
    • K. Jolley, L. Appleby, J.C. Wright, M. Christodoulides, and J.E. Heckels Immunisation with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci Infect Immun 69 2001 3809 3916
    • (2001) Infect Immun , vol.69 , pp. 3809-3916
    • Jolley, K.1    Appleby, L.2    Wright, J.C.3    Christodoulides, M.4    Heckels, J.E.5
  • 35
    • 0031552197 scopus 로고    scopus 로고
    • Meningococcal disease in England and Wales: 1995
    • E.B. Kaczmarski Meningococcal disease in England and Wales: 1995 Commun Dis Rep CDR Rev 7 1997 R55 R59
    • (1997) Commun Dis Rep CDR Rev , vol.7
    • Kaczmarski, E.B.1
  • 36
    • 0024712514 scopus 로고
    • The potential protective effect of immunization with outer membrane protein I from Neisseria gonorrhoeae
    • J.E. Heckels, J.N. Fletcher, and M. Virji The potential protective effect of immunization with outer membrane protein I from Neisseria gonorrhoeae J Gen Microbiol 135 1989 2269 2276
    • (1989) J Gen Microbiol , vol.135 , pp. 2269-2276
    • Heckels, J.E.1    Fletcher, J.N.2    Virji, M.3
  • 37
    • 0035851320 scopus 로고    scopus 로고
    • Serum bactericidal activity and isotype distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccine
    • E. de Kleijn, C. Vermont, B. Kuipers, C. Vermont, H. van Dijken, and H. Rumke Serum bactericidal activity and isotype distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccine Vaccine 20 2001 352 358
    • (2001) Vaccine , vol.20 , pp. 352-358
    • De Kleijn, E.1    Vermont, C.2    Kuipers, B.3    Vermont, C.4    Van Dijken, H.5    Rumke, H.6
  • 38
    • 0036073207 scopus 로고    scopus 로고
    • Immunisation with recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis
    • J.C. Wright, J.N. Williams, M. Christodoulides, and J.E. Heckels Immunisation with recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis Infect Immun 70 2002 4028 4034
    • (2002) Infect Immun , vol.70 , pp. 4028-4034
    • Wright, J.C.1    Williams, J.N.2    Christodoulides, M.3    Heckels, J.E.4
  • 39
    • 0242349640 scopus 로고    scopus 로고
    • Relative immunogenicity of PorA subtypes in a multivalent Neisseria meningitidis vaccine is not dependent on presentation form
    • T.A. Luijkx, H. van Dijken, H.J. Hamstra, B. Kuipers, P. van der Ley, and L. van Alphen Relative immunogenicity of PorA subtypes in a multivalent Neisseria meningitidis vaccine is not dependent on presentation form Infect Immun 71 2003 6367 6371
    • (2003) Infect Immun , vol.71 , pp. 6367-6371
    • Luijkx, T.A.1    Van Dijken, H.2    Hamstra, H.J.3    Kuipers, B.4    Van Der Ley, P.5    Van Alphen, L.6
  • 40
    • 0034607359 scopus 로고    scopus 로고
    • Biochemical and biophysical characterization of in vitro folded outer membrane porin PorA of Neisseria meningitidis
    • C. Jansen, A. Wiese, L. Reubsaet, N. Dekker, H. de Cock, and U. Seydel Biochemical and biophysical characterization of in vitro folded outer membrane porin PorA of Neisseria meningitidis Biochim Biophys Acta 1464 2000 284 298
    • (2000) Biochim Biophys Acta , vol.1464 , pp. 284-298
    • Jansen, C.1    Wiese, A.2    Reubsaet, L.3    Dekker, N.4    De Cock, H.5    Seydel, U.6
  • 41
    • 0028306035 scopus 로고
    • Expression of large amounts of neisserial porin proteins in Escherichia coli and refolding of the proteins into native trimers
    • H.L. Qi, J.Y. Tai, and M.S. Blake Expression of large amounts of neisserial porin proteins in Escherichia coli and refolding of the proteins into native trimers Infect Immun 62 1994 2432 2439
    • (1994) Infect Immun , vol.62 , pp. 2432-2439
    • Qi, H.L.1    Tai, J.Y.2    Blake, M.S.3
  • 42
    • 0033569344 scopus 로고    scopus 로고
    • Crystal structure of a Fab fragment in complex with a meningococcal serosubtype antigen and a protein G domain
    • J.P. Derrick, M.C.J. Maiden, and L.M. Feavers Crystal structure of a Fab fragment in complex with a meningococcal serosubtype antigen and a protein G domain J Mol Biol 293 1999 81 91
    • (1999) J Mol Biol , vol.293 , pp. 81-91
    • Derrick, J.P.1    Maiden, M.C.J.2    Feavers, L.M.3
  • 43
    • 0030174312 scopus 로고    scopus 로고
    • Immunization with meningococcal class 1 outer membrane protein produced in Bacillus subtilis and reconstituted in the presence of Zwittergent or Triton X-100
    • I. Idanpaan-Heikkila, E. Wahlstrom, S. Muttilainen, M. Nurminen, H. Kayhty, and M. Sarvas Immunization with meningococcal class 1 outer membrane protein produced in Bacillus subtilis and reconstituted in the presence of Zwittergent or Triton X-100 Vaccine 14 1996 886 891
    • (1996) Vaccine , vol.14 , pp. 886-891
    • Idanpaan-Heikkila, I.1    Wahlstrom, E.2    Muttilainen, S.3    Nurminen, M.4    Kayhty, H.5    Sarvas, M.6
  • 44
    • 0037379540 scopus 로고    scopus 로고
    • Cross-reactivity of antibodies against PorA after vaccination with a meningococcal B outer membrane vesicle vaccine
    • C.L. Vermont, H.H. van Dijken, A.J. Kuipers, W.C.M. Keijzers, R. De Groot, and L. van Alphen Cross-reactivity of antibodies against PorA after vaccination with a meningococcal B outer membrane vesicle vaccine Infect Immun 71 2003 1650 1655
    • (2003) Infect Immun , vol.71 , pp. 1650-1655
    • Vermont, C.L.1    Van Dijken, H.H.2    Kuipers, A.J.3    Keijzers, W.C.M.4    De Groot, R.5    Van Alphen, L.6
  • 46
    • 0037726798 scopus 로고    scopus 로고
    • Analysis of PorA variable region 3 in meningococci: Implications for vaccine policy?
    • S.C. Clarke, M.A. Diggle, P. Molling, M. Unemo, and P. Olcen Analysis of PorA variable region 3 in meningococci: implications for vaccine policy? Vaccine 21 2003 2468 2473
    • (2003) Vaccine , vol.21 , pp. 2468-2473
    • Clarke, S.C.1    Diggle, M.A.2    Molling, P.3    Unemo, M.4    Olcen, P.5
  • 47
    • 7044235512 scopus 로고    scopus 로고
    • Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students
    • J.Z. Jordens, J.N. Williams, G.R. Jones, M. Christodoulides, and J.E. Heckels Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students Infect Immun 72 2004 6503 6510
    • (2004) Infect Immun , vol.72 , pp. 6503-6510
    • Jordens, J.Z.1    Williams, J.N.2    Jones, G.R.3    Christodoulides, M.4    Heckels, J.E.5
  • 48
    • 0025359486 scopus 로고
    • Deduced amino acid sequences of class 1 protein (porA) from 3 strains of Neisseria meningitides - Synthetic peptides define the epitopes responsible for serosubtype specificity
    • B.T. McGuinness, A.K. Barlow, I.N. Clarke, J.E. Farley, E. Anilionis, and J.T. Poolman Deduced amino acid sequences of class 1 protein (porA) from 3 strains of Neisseria meningitides - synthetic peptides define the epitopes responsible for serosubtype specificity J Exp Med 171 1990 1871 1882
    • (1990) J Exp Med , vol.171 , pp. 1871-1882
    • McGuinness, B.T.1    Barlow, A.K.2    Clarke, I.N.3    Farley, J.E.4    Anilionis, E.5    Poolman, J.T.6
  • 49
    • 0031755972 scopus 로고    scopus 로고
    • Naturally occurring insertional inactivation of the porA gene of Neisseria meningitidis by integration of IS 1301
    • J. Newcome, K. Cartwright, S. Dyer, and J. McFadden Naturally occurring insertional inactivation of the porA gene of Neisseria meningitidis by integration of IS 1301 Mol Microbiol 30 1998 453 454
    • (1998) Mol Microbiol , vol.30 , pp. 453-454
    • Newcome, J.1    Cartwright, K.2    Dyer, S.3    McFadden, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.