Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis

Infection and Immunity

Volumn 70, Issue 8, 2002, Pages 4028-4034

  Wright, J Claire ^a   Williams, Jeannette N ^a   Christodoulides, Myron ^a   Heckels, John E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; AMPHOLYTE; BACTERIAL PROTEIN; DETERGENT; GENE PRODUCT; LIPOSOME; OUTER MEMBRANE PROTEIN; PHOSPHORYL LIPID A; PORIN; PROTEIN PORB; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADSORPTION; AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME IMMUNOASSAY; ESCHERICHIA COLI; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOFLUORESCENCE; IMMUNOGENICITY; MENINGITIS; MICELLE; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEPTICEMIA; SEROTYPE;

ANIMALS; ANTIBODIES, BACTERIAL; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENES, BACTERIAL; IMMUNOGLOBULIN ISOTYPES; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; MICE; MICE, INBRED BALB C; NEISSERIA MENINGITIDIS; PORINS; RECOMBINANT FUSION PROTEINS; VACCINATION; VACCINES, SYNTHETIC;

EID: 0036073207     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.8.4028-4034.2002     Document Type: Article

References (44)

1. Immunogenicity and protectivity of a new liposomal hepatitis A vaccine
2. The class 1 outer membrane protein of Neisseria meningitidis: Gene sequence and structural and immunological similarities to gonococcal porins
3. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway
4. Efficacy, safety, and immunogenicity of a meningococcal group B (15 P1.3) outer membrane protein vaccine in Iquique, Chile
5. Gonococcal outer membrane protein PIB comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies
6. Immunogenicity of liposome-associated and refined antigen oral cholera vaccines in Thai volunteers
7. A controlled clinical study of the effect of nasal immunization with a Streptococcus mutans antigen alone or incorporated into liposomes on induction of immune responses
8. Immunization with recombinant class 1 outer membrane protein from Neisseria meningitidis: Influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci
9. Immunization with synthetic peptides containing epitopes of the class 1 outer membrane protein of Neisseria meningitidis: Production of bactericidal antibodies on immunization with a cyclic peptide
10. Influence of adjuvants on the humoral immune response toward a synthetic peptide containing a B-cell epitope from meningococcal class 1 protein
11. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil
12. A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections
13. In vivo human immuneresponse to transferrin binding protein 2 and other iron-regulated proteins of Neisseria meningitidis
14. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis
15. Human immunity to the meningococcus. II. Development of natural immunity
16. Liposomes as immunological adjuvants
17. Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease
18. Humoral immune response to class 1 outer membrane protein during the course of meningococcal disease
19. Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes
20. The antibody response to a prototype liposome vaccine containing Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis
21. Immunization with meningococcal class 1 outer membrane protein produced in Bacillus subtilis and reconstituted in the presence of Zwittergent or Triton X-100
22. Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: Influence of sequence variation and levels of expression on the bactericidal immune response against meningococci
23. Lack of immunity in university students prior to an outbreak of serogroup C meningococcal infection
24. Human opsonins induced during meningococcal disease recognize outer membrane proteins PorA and PorB
25. Point mutation in meningococcal porA gene associated with increased endemic disease
26. Class 1 outer membrane protein of Neisseria meningitidis: Epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology
27. PorB3 outer membrane protein on Neisseria meningitidis is poorly accessible for antibody binding on live bacteria
28. Immune response of Brazilian children to a Neisseria meningitidis serogroup B outer membrane protein vaccine: Comparison with efficacy
29. Heterologous production of the P1 porin of Neisseria meningitidis in Bacillus subtilis: The effect of an N-terminal extension on the presentation of native-like epitopes
30. The Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis and reconstituted into phospholipid vesicles elicits antibodies to native P1 epitopes
31. Immunogenicity of two efficacious outer membrane protein-based serogroup B meningococcal vaccines among young adults in Iceland
32. Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine
33. Comparative evaluation of potential components for group B meningococcal vaccine by passive protection in the infant rat and in vitro bactericidal assay
34. Successful recovery of the normal electrophysiological properties of PorB (class 3) porin from Neisseria meningitidis after expression in Escherichia coli and renaturation
35. Long-term efficacy and immune responses following immunization with the RTS, S malaria vaccine
36. A prophylactic hepatitis B vaccine with a novel adjuvant system
37. Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection
38. Topology of outer membrane porins in pathogenic Neisseria spp
39. Non-detergent sulphobetaines-a new class of mild solubilizing agents for protein purification
40. Halophilic protein stabilization by the mild solubilizing agents sulphobetaine
41. Sequence analysis and relationships between meningococcal class 3 serotype proteins and other porins from pathogenic and non-pathogenic Neisseria species
42. Expression of Neisseria meningitidis class 1 porin as a fusion protein in Escherichia coli: The influence of liposomes and adjuvants on the production of a bactericidal immune response
43. Gonococcal porin vaccine evaluation-comparison of por proteosomes, liposomes, and blebs isolated from rmp deletion mutants
44. Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations