Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: Preliminary observations

International Journal of Lower Extremity Wounds

Volumn 4, Issue 4, 2005, Pages 214-224

  Wollina, Uwe ^a   Schmidt, Wolf Dieter ^b   Krönert, Claudia ^a   Nelskamp, Cornelia ^a   Scheibe, Armin ^b   Fassler, Dieter ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b Department of Photonics and Sensorics ^*  (Germany)

Author keywords

Collagen based matrix; Microcirculation; Pain; Remission spectroscopy; Venous ulcers; Wound score

Indexed keywords

CELLULOSE; COLLAGEN;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRANULATION TISSUE; HUMAN; LEG ULCER; MALE; MICROCIRCULATION; NONCONTACT REMISSION SPECTROSCOPY; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPECTROSCOPY; TREATMENT OUTCOME; VISUAL ANALOG SCALE; WOUND CARE; WOUND DRESSING; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; BANDAGES; CELLULOSE, OXIDIZED; COLLAGEN; DIAGNOSTIC TECHNIQUES AND PROCEDURES; EQUIPMENT DESIGN; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; PROSPECTIVE STUDIES; VARICOSE ULCER; WOUND HEALING;

EID: 28244469060     PISSN: 15347346     EISSN: None     Source Type: Journal    
DOI: 10.1177/1534734605283001     Document Type: Article

References (38)

1. Welkie JF, Comerota AJ, Kerr RP, Katz ML, Jayheimer EC, Brigham RA. The hemodynamics of venous ulceration. Ann Vasc Surg 1991;6:1-4.
2. Angle N, Bergan JJ. Chronic venous ulcer. BMJ 1997;314:1019-23.
3. Jünger M, Steins A, Hahn M, Hafner HM. Microcirculatory dysfunction in chronic venous insufficiency (CVI). Microcirculation 2000;7:S3-12.
4. Stücker M, Huntermann C, Bechara FG, Hoffmann K, Altmeyer P. Capillary blood cell velocity in periulcerous regions of the lower leg measured by laser Doppler anemometry. Skin Res Technol 2004;10:174-7.
5. Malanin K, Havu VK, Kolari PJ. Dynamics of cutaneous laser Doppler flux with concentration of moving blood cells and blood cell velocity in legs with venous ulcers and in healthy legs. Angiology 2004;55:37-42.
6. Partsch H, Menzinger G, Mostbeck A. Inelastic leg compression is more effective to reduce deep venous refluxes than elastic bandages. Dermatol Surg 1999;25:695-9.
7. Oduncu H, Clark M, Williams RJ. Effect of compression on blood flow in lower limb wounds. Int Wound J 2004;1:107-13.
8. Jünger M, Wollina U, Konnen R, Rabe E. Efficacy and tolerability of an ulcer compression stocking for therapy of chronic venous ulcer compared with a below-knee compression bandage: results from a prospective, randomized, multicentre trial. Curr Med Res Opin 2004;20:1613-23.
9. Schultz GS, Barillo DJ, Mozingo DW, Chin GA, The Wound Bed Advisory Board Members. Wound bed preparation and a brief history of TIME. Int Wound J 2004;1:19-32.
10. Domb AJ, Kost J, Wiseman DM, eds. Handbook of biodegradeable polymers. Amsterdam: Harwood Academic; 1997.
11. Dimitrijevich SD, Tatarko M, Gracy RW, Wise GE, Oakford LX. In vivo degradation of oxidized, regenerated cellulose. Carbohydr Res 1990;198:331-41.
12. Cullen B, Watt PM, Lundqvist C, et al. The role of oxidised regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol 2002;34:1544-56.
13. Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW. The role of oxidised regenerated cellulose/collagen in wound repair: effects on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;1315:1-14.
14. Yager DR, Chen SM, Ward SI, Olutoye OO, Diegelmann RF, Cohen IK. Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors. Wound Rep Reg 1997;5:23-32.
15. Cullen B, Smith R, McCullouch E, Silcock D, Morrison L. Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers. Wound Rep Reg 2002;10:16-25.
16. Marshall M. Praktische Phlebologie. Berlin: Springer-Verlag; 1987.
17. Kistner RL, Eklof B, Masuda EM. Diagnosis of chronic venous disease of the lower extremities: the "CEAP" classification. Mayo Clin Proc 1996;71:338-45.
18. Korting HC, Callies R, Reusch M, Schlaeger M, Schöpf E, Sterry W. Dermatologische Qualitätssicherung. Leitlinien und Empfehlungen. 2nd ed. München: W. Zuckschwerdt Verlag; 2001.
19. Schmidt W-D, Liebold K, Faßler D, Wollina U. Contact-free remission spectroscopy of leg ulcers: principle, technique, and calculation of spectroscopic wound scores. J Invest Dermatol 2001;116:531-5.
20. Anderson RR, Parrish JA. The optics of human skin. J Invest Dermatol 1981;77:13-9.
21. Ferrari M, Mottola L, Quaresima V. Principles, techniques, and limitations of near infrared spectroscopy. Can J Appl Physiol 2004;29:463-87.
22. Attas M, Hewko M, Payette J, Posthumus T, Sowa M, Mantsch H. Visualization of cutaneous haemoglobin oxygenation and skin hydration using near-infrared spectroscopic imaging. Skin Res Technol 2001;7:238-45.
23. Liebold K, Faßler D, Schmidt W-D, Kühn T, Wollina U. In vivo spectroscopy in dermatology: methods and new fields of application. J Eur Acad Dermatol Venereol 2000;14:1-4.
24. Karamfilov T, Weichold S, Karte K, Vilser W, Wollina U. Remittance spectroscopy mapping of human skin in vivo. Skin Res Technol 1999;5:49-52.
25. Geyer A, Vilser W, Karte K, Wollina U. Remittance spectroscopy of human skin in vivo. Skin Res Technol 1996;2:122-5.
26. Schmidt W-D, Faßler D, Zimmermann G, Liebold K, Wollina U. Non-contacting diffuse VIS-NIR spectroscopy of human skin for evaluation of skin type and time-dependent microcirculation. Proc SPIE 2000;4160:91-102.
27. Mannheimer PD, Fein ME, Casciani JR. Physico-optical considerations in the design of fetal pulse oximetry sensors. Eur J Obstet Gynecol Reprod Biol 1997a;72(Suppl):S9-19.
28. Mannheimer PD, Casciani JR, Fein ME, Nierlich SL. Wavelength selection for low saturation pulse oximetry. IEEE Trans Biomed Eng 1997b;44:148-58.
29. Schmidt W-D, Konrad H, Scheibe A, et al. Vis-NIR spectroscopic and clinical evaluations of the response of spider leg veins to a high-powered, pulsed diode laser (810 nm) therapy. Proc SPIE-OSA 2003;5142:50-8.
30. Mannheimer PD, Casciani JR, Fein ME, Nierlich SL. Wavelength selection for low-saturation pulse oximetry. IEEE Trans Biomed Eng 1997;4:148-58.
31. Zonios G, Bykowski J, Kollias N. Skin melanin, haemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy. J Invest Dermatol 2001;117:1452-7.
32. Vin F, Teot L, Meaume S. The healing properties of Promogran in venous leg ulcers. J Wound care 2002;11:335-41.
33. Veves A, Sheehan P, Pham HT. A randomized, controlled trial of Promogran (a collagen/oxidized cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg 2002;137:822-7.
34. Gschwandtner ME, Ehringer H. Microcirculation in chronic venous insufficiency. Vasc Med 2001;6:169-79.
35. Roberts G, Hammad L, Collins C, Shearman C, Mani R. Some effects of sustained compression on ulcerated tissues. Angiology 2002;53:451-6.
36. Steins A, Hahn M, Jünger M. Venous leg ulcers and microcirculation. Clin Hemorheol Microcirc 2001;24:147-53.
37. Dye J, Lawrence L, Linge C, Leach L, Firth J, Clark P. Distinct patterns of microvascular endothelial cell morphology are determined by extracellular matrix composition. Endothelium 2004;11:151-67.
38. Liu Y, Senger DR. Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells. FASEB J 2004;18:457-68.