메뉴 건너뛰기




Volumn 35, Issue 8-9, 2005, Pages 721-726

Mode of action: Inhibition of androgen receptor function - Vinclozolin-induced malformations in reproductive development

Author keywords

Birth Defects; Flutamide; Human Relevance; Reproductive Toxicity; Testosterone; TRPM 3

Indexed keywords

ANDROGEN RECEPTOR; VINCLOZOLIN;

EID: 28144462880     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440591007377     Document Type: Article
Times cited : (62)

References (26)
  • 1
    • 0033941717 scopus 로고    scopus 로고
    • Testicular position in the androgen insensitivity syndrome: Implications for the role of androgens in testicular descent
    • Barthold, J.S., Kumasi-Rivers, K., Upadhyay, J., Shekarriz, B., and Imperato-McGinley, J. (2000). Testicular position in the androgen insensitivity syndrome: Implications for the role of androgens in testicular descent. J. Urol. 164:497-501.
    • (2000) J. Urol. , vol.164 , pp. 497-501
    • Barthold, J.S.1    Kumasi-Rivers, K.2    Upadhyay, J.3    Shekarriz, B.4    Imperato-McGinley, J.5
  • 2
    • 0036772805 scopus 로고    scopus 로고
    • Response-surface modeling of the effects of 5alpha-dihydrotestosterone and androgen receptor levels on the response to the androgen receptor antagonist vinclozolin
    • Euling, S.Y., Gennings, C., Wilson, E.M., Kemppained, J.A., Kelce, W.R., and Kimmel, C.A. (2002). Response-surface modeling of the effects of 5alpha-dihydrotestosterone and androgen receptor levels on the response to the androgen receptor antagonist vinclozolin. Toxicol. Sci. 69:332-343.
    • (2002) Toxicol. Sci. , vol.69 , pp. 332-343
    • Euling, S.Y.1    Gennings, C.2    Wilson, E.M.3    Kemppained, J.A.4    Kelce, W.R.5    Kimmel, C.A.6
  • 3
    • 0027937899 scopus 로고
    • Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
    • Gray, L.E., Jr., Ostby, J.S., and Kelce, W.R. (1994). Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat. Toxicol. Appl. Pharmacol. 129:46-52.
    • (1994) Toxicol. Appl. Pharmacol. , vol.129 , pp. 46-52
    • Gray Jr., L.E.1    Ostby, J.S.2    Kelce, W.R.3
  • 4
    • 0343962125 scopus 로고    scopus 로고
    • Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
    • Gray, L.E., Jr., Ostby, J.S., Monosson, E., and Kelce, W.R. (1999). Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicol. Ind. Health 15:48-64.
    • (1999) Toxicol. Ind. Health , vol.15 , pp. 48-64
    • Gray Jr., L.E.1    Ostby, J.S.2    Monosson, E.3    Kelce, W.R.4
  • 6
    • 0036925449 scopus 로고    scopus 로고
    • 5-alpha-reductase-2 deficiency and complete androgen insensitivity: Lessons from nature
    • Imperato-McGinley, J. (2002). 5-alpha-reductase-2 deficiency and complete androgen insensitivity: Lessons from nature. Adv. Exp. Med. Biol. 511:121-131.
    • (2002) Adv. Exp. Med. Biol. , vol.511 , pp. 121-131
    • Imperato-McGinley, J.1
  • 7
    • 0030988408 scopus 로고    scopus 로고
    • The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat
    • Kassim, N.M., McDonald, S.W., Reid, O, Bennett, N.K., Gilmore, D.P., and Payne, A.P. (1997). The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat. J. Anat. 190:577-588.
    • (1997) J. Anat. , vol.190 , pp. 577-588
    • Kassim, N.M.1    McDonald, S.W.2    Reid, O.3    Bennett, N.K.4    Gilmore, D.P.5    Payne, A.P.6
  • 8
    • 0028228821 scopus 로고
    • Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
    • Kelce, W.R., Monosson, E., Gamcsik, M.P., Laws, S.C., and Gray, L.E., Jr. (1994). Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol. Appl. Pharmacol. 126:276-285.
    • (1994) Toxicol. Appl. Pharmacol. , vol.126 , pp. 276-285
    • Kelce, W.R.1    Monosson, E.2    Gamcsik, M.P.3    Laws, S.C.4    Gray Jr., L.E.5
  • 9
    • 0031019418 scopus 로고    scopus 로고
    • Vinclozolin and p, p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism
    • Kelce, W.R., Lambright, C.R., Gray, L.E., Jr., and Roberts, K.P. (1997). Vinclozolin and p, p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism. Toxicol. Appl. Pharmacol. 142:192-200.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 192-200
    • Kelce, W.R.1    Lambright, C.R.2    Gray Jr., L.E.3    Roberts, K.P.4
  • 10
    • 0029950452 scopus 로고    scopus 로고
    • Genotoxicity of selected pesticides in the mouse bone-marrow micronucleus test and in the sister-chromatid exchange test with human lymphocytes in vitro
    • Kevekordes, S., Gebel, T., Pav, K., Edenharder, R., and Dunkelberg, H. (1996). Genotoxicity of selected pesticides in the mouse bone-marrow micronucleus test and in the sister-chromatid exchange test with human lymphocytes in vitro. Toxicol. Lett. 89(1):35-42.
    • (1996) Toxicol. Lett. , vol.89 , Issue.1 , pp. 35-42
    • Kevekordes, S.1    Gebel, T.2    Pav, K.3    Edenharder, R.4    Dunkelberg, H.5
  • 11
    • 10044236969 scopus 로고    scopus 로고
    • Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells
    • Kojimo, H., Katsura, E., Takeuck, S., Niiyama, K., and Kobayashi, K. (2004). Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 112(5):524-531.
    • (2004) Environ. Health Perspect. , vol.112 , Issue.5 , pp. 524-531
    • Kojimo, H.1    Katsura, E.2    Takeuck, S.3    Niiyama, K.4    Kobayashi, K.5
  • 12
    • 0030565503 scopus 로고    scopus 로고
    • Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro
    • Laws, S.C., Carey, S.A., Kelce, W.R., Cooper, R.L., and Gray, L.E., Jr. (1996). Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro. Toxicology 112(3):173-182.
    • (1996) Toxicology , vol.112 , Issue.3 , pp. 173-182
    • Laws, S.C.1    Carey, S.A.2    Kelce, W.R.3    Cooper, R.L.4    Gray Jr., L.E.5
  • 13
    • 0031879838 scopus 로고    scopus 로고
    • Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX-E9636
    • Lioi, M.B., Scarfi, M.R., Santoro, A., Barbieri, R., Zeni, O., Salvemini, F., Di Berardino, D., and Ursini, M.V. (1998). Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX-E9636. Environ. Mol. Mutagen. 32(1):39-46.
    • (1998) Environ. Mol. Mutagen. , vol.32 , Issue.1 , pp. 39-46
    • Lioi, M.B.1    Scarfi, M.R.2    Santoro, A.3    Barbieri, R.4    Zeni, O.5    Salvemini, F.6    Di Berardino, D.7    Ursini, M.V.8
  • 14
    • 0034894623 scopus 로고    scopus 로고
    • Androgen-dependent development of male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    • McIntyre, B.S., Barlow, N.J., and Foster, P.M. (2001). Androgen-dependent development of male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol. Sci. 62:236-249.
    • (2001) Toxicol. Sci. , vol.62 , pp. 236-249
    • McIntyre, B.S.1    Barlow, N.J.2    Foster, P.M.3
  • 15
    • 0036213832 scopus 로고    scopus 로고
    • Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats
    • Miyata, K., Yabushita, S., Sukata, T., Yoshino, H., Nakanishi, T., Okuno Y., and Matsuo, M. (2002). Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats. J. Toxicol. Sci. 27:19-33.
    • (2002) J. Toxicol. Sci. , vol.27 , pp. 19-33
    • Miyata, K.1    Yabushita, S.2    Sukata, T.3    Yoshino, H.4    Nakanishi, T.5    Okuno, Y.6    Matsuo, M.7
  • 16
    • 0033360298 scopus 로고    scopus 로고
    • Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the rat
    • Monosson, E., Kelce, W.R., Lambright, C., Ostby, J., and Gray, L.E., Jr. (1999). Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the rat. Toxicol. Ind. Health 15:65-79.
    • (1999) Toxicol. Ind. Health , vol.15 , pp. 65-79
    • Monosson, E.1    Kelce, W.R.2    Lambright, C.3    Ostby, J.4    Gray Jr., L.E.5
  • 17
    • 0006545011 scopus 로고    scopus 로고
    • Long-term studies of fungicide concentrations in greenhouses. 3. Exposure risks after spraying in greenhouses
    • Nilsson, U., and Papantoni, M. (1996) Long-term studies of fungicide concentrations in greenhouses. 3. Exposure risks after spraying in greenhouses. J. Agric. Food Chem. 44(9):2885-2888.
    • (1996) J. Agric. Food Chem. , vol.44 , Issue.9 , pp. 2885-2888
    • Nilsson, U.1    Papantoni, M.2
  • 18
    • 0034583270 scopus 로고    scopus 로고
    • The molecular basis of androgen insensitivity
    • Nitche, E.M., and Hiort, O. (2000). The molecular basis of androgen insensitivity. Horm. Res. 54:327-333.
    • (2000) Horm. Res. , vol.54 , pp. 327-333
    • Nitche, E.M.1    Hiort, O.2
  • 20
    • 3242882452 scopus 로고    scopus 로고
    • Liquid chromatography determination of the anti-androgen vinclozolin and its metabolites in rat serum
    • Sierra-Santoyo, A., Barton, H.A., and Hughes, M.F. (2004). Liquid chromatography determination of the anti-androgen vinclozolin and its metabolites in rat serum. J. Chromatogr. B Analyt. Technol. Biomed. 809(1):105-110.
    • (2004) J. Chromatogr. B Analyt. Technol. Biomed. , vol.809 , Issue.1 , pp. 105-110
    • Sierra-Santoyo, A.1    Barton, H.A.2    Hughes, M.F.3
  • 21
    • 70350159627 scopus 로고    scopus 로고
    • Case No. 2740. Office of Prevention, Pesticides, and Toxic Substances. EPA 738-R-00-023
    • US Environmental Protection Agency. (2000). Reregistration eligibility decision (RED). Vinclozolin. Case No. 2740. Office of Prevention, Pesticides, and Toxic Substances. EPA 738-R-00-023 (www.epa.gov/REDs/2740red.pdf).
    • (2000) Reregistration Eligibility Decision (RED). Vinclozolin
  • 23
    • 0036192083 scopus 로고    scopus 로고
    • A novel cell line, MDA-kb2, that stably expresses an androgen and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists
    • Wilson, V.S., Bobseine, K., Lambright, C.R., and Gray, L.E., Jr. (2002). A novel cell line, MDA-kb2, that stably expresses an androgen and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists. Toxicol. Sci. 66:69-81.
    • (2002) Toxicol. Sci. , vol.66 , pp. 69-81
    • Wilson, V.S.1    Bobseine, K.2    Lambright, C.R.3    Gray Jr., L.E.4
  • 25
    • 0029123855 scopus 로고
    • Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide
    • Wong, C., Kelce, W.R., Sar, M., and Wilson, E.M. (1995). Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J. Biol. Chem. 270:19998-20003.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19998-20003
    • Wong, C.1    Kelce, W.R.2    Sar, M.3    Wilson, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.