Adverse events after protamine administration following cardiopulmonary bypass in infants and children

Anesthesia and Analgesia

Volumn 97, Issue 2, 2003, Pages 383-389

  Seifert, Harry A ^a,b,c   Jobes, David R ^b   Have, Thomas Ten ^a   Kimmel, Stephen E ^a   Montenegro, Lisa M ^b   Steven, James M ^b   Nicolson, Susan C ^b   Strom, Brian L ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; HEPARIN; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTAMINE;

ARTICLE; CARDIOPULMONARY BYPASS; CASE CONTROL STUDY; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HEART FAILURE; HUMAN; HYPOTENSION; INCIDENCE; INFANT; LUNG DISEASE; MALE; MEDICAL DOCUMENTATION; PEDIATRIC ANESTHESIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SEX RATIO;

EID: 0042347888     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000072545.13681.FA     Document Type: Article

References (23)

1. Conahan T, Andrews R, MacVaugh H. Cardiovascular effects of protamine sulfate in man. Anesth Analg 1981;60:33-6.
2. Horrow JC. Protamine: a review of its toxicity. Anesth Analg 1985;64:348-61.
3. Ovrum E, Lindberg H, Holen EA, et al. Systemic and pulmonary circulatory effects of protamine following cardiopulmonary bypass in man. Scand J Thorac Cardiovasc Surg 1991;25:19-24.
4. Schapira M, Christman BW. Neutralization of heparin by protamine. Circulation 1990;82:1877-9.
5. Levy JH, Schwieger IM, Zaidan JR, et al. Evaluation of patients at risk for protamine reactions. J Thorac Cardiovasc Surg 1989; 98:200-4.
6. Weiler JM, Gellhaus MA, Carter JG, et al. A prospective study of the risk of an immediate adverse reaction to protamine sulfate during cardiopulmonary bypass surgery. J Allergy Clin Immunol 1990;85:713-9.
7. Kimmel S, Sekeres M, Berlin J, et al. Adverse events after protamine administration in patients undergoing cardiopulmonary bypass: risks and predictors of under-reporting. J Clin Epidemiol 1998;51:1-10.
8. Kambam J, Meszaros R, Merrill W, et al. Prophylactic administration of histamine1 and histamine2 receptor blockers in the prevention of protamine-related haemodynamic effects. Can J Anaesth 1990;37:420-2.
9. Weiss M, Nyhan D, Peng Z. Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine. N Engl J Med 1989;320:886-92.
10. Levy JH, Zaidan JR, Faraj B. Prospective evaluation of risk of protamine reactions in patients with NPH insulin-dependent diabetes. Anesth Analg 1986;65:739-42.
11. Gottschlich GM, Gravlee GP, Georgitis JW. Adverse reactions to protamine sulfate during cardiac surgery in diabetic and nondiabetic patients. Ann Allergy 1988;61:277-81.
12. Knape J, Schuler J, Haan PD. An anaphylactic reaction to protamine in a patient allergic to fish. Anesthesiology 1981;55: 324-5.
13. Kimmel S, Sekeres M, Berlin J, et al. Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass. J Am Coll Cardiol 1998;32: 1916-22.
14. Gupta SK, Veith FJ, Ascer E, et al. Anaphylactoid reactions to protamine: an often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery. J Vasc Surg 1989; 9:342-50.
15. Horiguchi T, Enzan K, Kawamura K, Suzuki M. Pulmonary responses to heparin-protamine complexes: the effects of age and species. J Appl Physiol 1996;80:56-61.
16. Sanborn KV, Castro J, Kuroda M, Thys DM. Detection of intraoperative incidents by electronic scanning of computerized anesthesia records. Anesthesiology 1996;85:977-87.
17. Kirklin JK, Chenoweth DE, Naftel DC, et al. Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state. Ann Thorac Surg 1986;41:193-9.
18. Shapira N, Schaff HV, Piehler JM, et al. Cardiovascular effects of protamine sulfate in man. Thorac Cardiovasc Surg 1982;84:505-14.
19. Schlesselman JJ. Case-control studies: design, conduct, analysis. New York: Oxford University Press, 1982.
20. Adourian U, Shampaine E, Hirshman C, et al. High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiology 1993;78:368-72.
21. Mickey RM, Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol 1989;129:125-37.
22. van der Klauw AM, Wilson JHP, Stricker BHC. Drug-associated anaphylaxis: 20 years of reporting in the Netherlands (1974-1994) and review of the literature. Clin Exp Allergy 1996; 26:1355-63.
23. Kimmel SE, Sekeres M, Berlin JA, Ellison N. Mortality and adverse events following protamine administration in patients undergoing cardiopulmonary bypass. Anesth Analg 2002;94: 1402-8.