Relationships of Cysteine and Lysine residues with the substrate binding site of the mitochondrial ornithine/citrulline carrier: An inhibition kinetic approach combined with the analysis of the homology structural model

Biochimica et Biophysica Acta - Biomembranes

Volumn 1718, Issue 1-2, 2005, Pages 53-60

  Tonazzi, Annamaria ^a,c   Giangregorio, Nicola ^a,c   Palmieri, Ferdinando ^c   Indiveri, Cesare ^b,c  

^a CNR   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Carrier; Liposome; Membrane; Mitochondria; Ornithine; Reconstitution; Structure; Transport

Indexed keywords

(2 AMINOETHYL)METHANETHIOSULFONATE HYDROBROMIDE; 1 ETHYL 3 (3 DIMETHYLAMINOPROPYL)CARBODIIMMIDE; 4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; AMIDE; ARGININE; BROMINE DERIVATIVE; CARBONYL DERIVATIVE; CARBOXYLIC ACID; CARRIER PROTEIN; CITRULLINE; CYANAMIDE; CYSTEINE; DIAMIDE; HYDROXYMERCURIBENZOIC ACID; LIPOSOME; LYSINE; N ETHYLMALEIMIDE; ORNITHINE; PYRIDOXAL 5 PHOSPHATE; REAGENT; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; COMPETITIVE INHIBITION; DATA ANALYSIS; EXPERIMENT; INHIBITION KINETICS; MITOCHONDRION; MOLECULE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; 4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID; AMINO ACID TRANSPORT SYSTEMS, BASIC; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CITRULLINE; CYSTEINE; LYSINE; MUTATION; ORNITHINE; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; RATS; STRUCTURAL HOMOLOGY, PROTEIN; SULFHYDRYL REAGENTS;

EID: 28144459323     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2005.10.007     Document Type: Article

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