Midazolam and its metabolites in brain death diagnosis

International Journal of Clinical Pharmacology and Therapeutics

Volumn 43, Issue 11, 2005, Pages 517-526

  Meinitzer, A ^a   Zink, M ^a   Marz W ^a   Baumgartner, A ^a   Halwachs Baumann, Gabriele ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Brain death diagnosis; Midazolam; Pharmacokinetics

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA HYDROXYMIDAZOLAM; ASPARTATE AMINOTRANSFERASE; BENZODIAZEPINE; BILIRUBIN; CHOLINESTERASE; CREATININE; DRUG METABOLITE; GAMMA GLUTAMYLTRANSFERASE; MIDAZOLAM; NORDAZEPAM; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLISM; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; BRAIN DEATH; CASE REPORT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG WITHDRAWAL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEAD INJURY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; INTRACRANIAL PRESSURE; LABORATORY DIAGNOSIS; ORGAN DONOR; SUBARACHNOID HEMORRHAGE; TIME; UREA BLOOD LEVEL;

EID: 28044464271     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP43517     Document Type: Article

References (37)

1. Ahrens B, Schwandt HJ, Schutz H 2000 Screening, identification and quantitation of benzodiazepines in serum by solid phase extraction on a cyanopropyl phase using high-performance liquid chromatography and photodiode array detection. Arzneimittelforschung 50: 1057-1062
2. Albrecht S, Ihmsen H, Hering W, Geisslinger G, Dingemanse J, Schwilden H, Schuttler J 1999 The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 65: 630-639
3. Bauer TM, Ritz R, Haberthur C, Ha HR, Hunkeler W, Sleight AJ, Scollo Lavizzari G, Haefeli WE 1995 Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 346: 145-147
4. Becker J, Correll A, Koepf W, Rittner C 1993 Comparative studies on the detection of benzodiazepines in serum by means of immunoassays (FPIA). J Anal Toxicol 17: 103-108
5. Clarke's Analysis of Drugs and Poisons. 2003 Third edition. The Pharmaceutical Press, London
6. Crevat-Pisano P, Dragna S, Granthil C, Coassolo P, Cano JP, Francois G 1986 Plasma concentrations and pharmacokinetics of midazolam during anaesthesia. J Pharm Pharmacol 38: 578-582
7. Dirksen MS, Vree TB, Driessen JJ 1987 Clinical pharmacokinetics of long-term infusion of midazolam in critically ill patients - preliminary results. Anaesth Intensive Care 15: 440-444
8. Drummer OH 1998 Methods for the measurement of benzodiazepines in biological samples. J Chromatogr B Biomed Sci Appl 713: 201-225
9. Dundee JW, Collier PS, Carlisle RJ, Harper KW 1986 Prolonged midazolam elimination half-life. Br J Clin Pharmacol 21: 425-429
10. Gill R, Law B, Gibbs JP 1986 High-performance liquid chromatography systems for the separation of benzodiazepines and their metabolites. J Chromatogr 356: 37-46
11. Herrlin K, Segerdahl M, Gustafsson LL, Kalso E 2000 Methadone, ciprofloxacin, and adverse drug reactions. Lancet 356: 2069-2070
12. Hirata K, Matsumoto Y, Kurokawa A, Onda M, Shimizu M, Fukuoka M, Hirano M, Yamamoto Y 2003 Possibility of influence of midazolam sedation on the diagnosis of brain death: concentrations of active metabolites after cessation of midazolam. Yakugaku Zasshi 123: 811-815
13. Hotz MA, Ritz R, Linder L, Scollo Lavizzari G, Haefeli WE 2000 Auditory and electroencephalographic effects of midazolam and alpha-hydroxy-midazolam in healthy subjects. Br J Clin Pharmacol 49: 72-79
14. Huang W, Moody DE 1995 Immunoassay detection of benzodiazepines and benzodiazepine metabolites in blood. J Anal Toxicol 19: 333-342
15. ICH (International Conference on Harmonisation) Guidelines. Text on Validation of Analytical Procedures Oct 1994, Validation of Analytical Procedures: Methodology Nov 1996
16. Inoue H, Maeno Y, Iwasa M, Matoba R, Nagao M 2000 Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry. Forensic Sci Int 113: 367-373
17. Kochs E, Roewer N, Peter A, Schulte am Esch J 1988 Effect of flumazenil on global cerebral blood flow and on intracranial pressure in the reperfusion phase following incomplete global cerebral ischemia. Anasthesiol Intensivmed Notfallmed 23: 159-162
18. Lopez-Navidad A, Caballero F, Domingo P, Marruecos L, Estorch M, Kulisevsky J, Mora J 2000 Early diagnosis of brain death in patients treated with central nervous system depressant drugs. Transplantation 70: 131-135
19. MacGilchrist AJ, Birnie GG, Cook A, Scobie G, Murray T, Watkinson G, Brodie MJ 1986 Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis. Gut 27: 190-195
20. Mazhar M, Binder SR 1989 Analysis of benzodiazepines and tricyclic antidepressants in serum using a common solid-phase clean-up and a common mobile phase. J Chromatogr 497: 201-212
21. Morris RG 1996 Drugs and brain death. Drug assay perspectives. Clin Exp Pharmacol Physiol 23: 42-43
22. Nordt SP, Clark RF 1997 Midazolam: a review of therapeutic uses and toxicity. J Emerg Med 15: 357-365
23. Oldenhoff H, De Jong M, Steenhoek A, Janknegt R 1988 Clinical pharmacokinetics of midazolam in intensive care patients, a wide interpatient variability? Clin Pharmacol Ther 43: 263-269
24. Pelkonen O, Mäenpää J, Taavitsainen P, Rautio A, Raunio H 1998 Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28: 1203-1253
25. Pentikainen PJ, Valisalmi L, Himber JJ, Crevoisier C 1989 Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and healthy subjects. J Clin Pharmacol 29: 272-277
26. Pratschke J, Wilhelm MJ, Kusaka M, Beato F, Milford EL, Hancock WW, Tilney NL 2000 Accelerated rejection of renal allografts from brain-dead donors. Ann Surg 232: 263-271
27. Ramoska EA, Linkenheimer R, Glasgow C 1991 Midazolam use in the emergency department. J Emerg Med 9: 247-251
28. van Rij KM, Compas D, Swart EL, de Goede PN, Touw DJ 1999 Reversed-phase ion-pair HPLC method for the direct analysis of 1-OH midazolam glucuronide in human serum. Ther Drug Monit 21: 416-420
29. Schulte am Esch J, Kochs E 1990 Midazolam and flumazenil in neuroanaesthesia. Acta Anesthesiol Scand 92 (Suppl): 96-102
30. Schwenzer KS, Pearlman R, Tsilimidos M, Salamone SJ, Cannon RC, Wong SH, Gock SB, Jentzen JJ 2000 New fluorescence polarization immunoassays for analysis of barbiturates and benzodiazepines in serum and urine. J Anal Toxicol 24: 726-732
31. Shafer A, Doze VA, White PF 1990 Pharmacokinetic variability of midazolam infusions in critically ill patients. Crit Care Med 18: 1039-1041
32. Shemesh O, Golbetz H, Kriss JP, Myers BD 1985 Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 28: 830-838
33. Sioufi A, Dubois JP 1990 Chromatography of benzodiazepines. J Chromatogr 531: 459-480
34. Tullius SG, Volk HD, Neuhaus P 2001 Transplantation of organs from marginal donors. Transplantation 72: 1341-1349
35. Way BA, Walton KG, Koenig JW, Eveland BJ, Scott MG 1998 Comparison between the CEDIA and EMIT II immunoassays for the determination of benzodiazepines. Clin Chim Acta 271: 1-9
36. Wijdicks EFM 2001 The diagnosis of brain death. N Engl J Med 344: 1215-1221
37. Wijdicks EFM 2001 Neurologic states resembling brain death. In: Brain death. Williams & Wilkins Publishers, Baltimore, pp 115-134