Screening, identification and quantitation of benzodiazepines in serum by solid phase extraction on a cyanopropyl phase using high performance liquid chromatography and photodiode array detection

Arzneimittel-Forschung/Drug Research

Volumn 50, Issue 12, 2000, Pages 1057-1062

  Ahrens, B ^a   Schwandt, H J ^a   Schutz, H ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Benzodiazepines, determination in serum, screening; Diazepam; Flunitrazepam; Nordazepam; Oxazepam; Temazepam

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLUNITRAZEPAM; NORDAZEPAM; OXAZEPAM; TEMAZEPAM;

ARTICLE; ASSAY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; SOLID PHASE EXTRACTION; VALIDATION PROCESS;

EID: 0034536665     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300347     Document Type: Article

References (14)

1. Evaluation of EMIT-TOX enzyme immunoassay for the analysis of benzodiazepine in serum: Usefulness and limitations in an emergency laboratory
2. Detection of benzodiazepine intake in therapeutic doses by immunoanalysis of urine: Two techniques evaluated and modified for improved performance
3. The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry
4. Therapeutic and toxic blood concentrations of more than 500 drugs
5. Identification of urinary benzodiazepines and their Metabolites: Comparison of automated HPLC and GC-MS after immunoassay screening of clinical specimens
6. Identification of parent benzodiazepines by gas chromatography/mass spectrometry (GC/MS) from urinary extracts treated with β-glucuronidase
7. Screening, identification, and quantitation of benzodiazepines in postmortem samples by HPLC with photodiode array detection
8. A rapid solid-phase extraction and HPLC/DAD procedure for the simultaneous determination and quantification of different benzodiazepines in serum, blood and post-mortem blood
9. A screening test for pharmaceuticals, drugs and insecticides with reversed phase liquid chromatography - Retention data of 560 compounds
10. Anwendbarkeit verschiedener extraktionsmethoden fur die Opiat-Analytik im Blut. Drogenkontrolle in der heutigen Gesellschaft
11. Applicabillity of various brands of mixed-phase extraction columns for opiate extraction from blood and serum