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Bach FH. Heme oxygenase-1: a therapeutic amplification funnel. FASEB J 2005; 19:1216-1219. This article continues the work of this author on the emerging importance of heme oxygenase-1 in accommodation and other physiologic pathways.
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Accommodation of vascularized xenografts: Expression of 'protective genes' by donor endothelial cells in a host Th2 cytokine environment
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Tolerance or accommodation: The lesson from leflunomide
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Sebille F, Dorling A. Tolerance or accommodation: the lesson from leflunomide. Transplantation 2005; 79:133-134. This discussion examines the potential interplay between mechanisms that may ultimately lead to either tolerance or accommodation or both.
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Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
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Chen D, Weber M, McVey JH, et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004; 4:1958-1963. This important study elegantly examines the role of coagulation in graft damage vs protection in the presence of antidonor antibody.
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A new concept of accommodation in ABO-incompatible kidney transplantation
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Takahashi K. A new concept of accommodation in ABO-incompatible kidney transplantation. Clin Transplant 2005; 19(Suppl 14):76-85. This paper discusses evolving concepts of graft accommodation in clinical transplantation.
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Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation
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Fan X, Ang A, Pollock-Barziv SM, et al. Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nat Med 2004; 10:1227-1233. This paper reports the immunologic development of infants following ABO-incompatible heart transplantation. Its importance lies in the careful delineation of B-cell tolerance in human infants.
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Fan, X.1
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Histo-blood group type change of the graft from B to O after ABO mismatched heart transplantation
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Koestner SC, Kappeler A, Schaffner T, et al. Histo-blood group type change of the graft from B to O after ABO mismatched heart transplantation. Lancet 2004; 363:1523-1525. This article reports an elegant demonstration of blood group antigens in the graft of an ABO-incompatible heart transplant, and their change over time from donor to recipient blood type.
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Targeting antibody-mediated rejection in the setting of ABO-incompatible infant heart transplantation: Graft accommodation vs. B cell tolerance
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West LJ. Targeting antibody-mediated rejection in the setting of ABO-incompatible infant heart transplantation: graft accommodation vs. B cell tolerance. Curr Drug Targets Cardiovasc Haematol Disord 2005; 5:223-232. This paper offers a discussion of the relative likelihood of tolerance vs accommodation in the setting of antibody to donor antigens.
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Developmental aspects of immunomodulation: Exploiting the immature immune system for organ transplantation
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West LJ Developmental aspects of immunomodulation: exploiting the immature immune system for organ transplantation. Transpl Immunol 2002; 9:149-153.
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Immunopathology of hyperacute xenograft rejection in a swine-to-primate model
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Platt JL, Fischel RJ, Matas AJ, et al. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 1991; 52:214-220.
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Cardiac xenotransplantation: Future and limitations
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Ogata K, Platt JL. Cardiac xenotransplantation: future and limitations. Cardiology 2004; 101:144-155. This article offers a discussion of the future of cardiac xenotransplantation, drawing lessons from investigations into antibody-mediated responses.
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Human ABO-incompatible organ transplantation as a clinical surrogate for discordant xenotransplantation? The role of accommodation vs. B cell tolerance
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West LJ. Human ABO-incompatible organ transplantation as a clinical surrogate for discordant xenotransplantation? The role of accommodation vs. B cell tolerance. Xenotransplantation 2005; 12:366. This paper presents a brief discussion of the possibilities for ABO-incompatible organ transplantation to serve as a clinical surrogate for investigation of issues of importance to xenotransplantation.
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West, L.J.1
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