Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis

International Journal of Cancer

Volumn 117, Issue 6, 2005, Pages 934-941

  Raguz, Selina ^a   De Bella, Manuela Tamburo ^a   Slade, Martin J ^a   Higgins, Christopher F ^a   Coombes, R Charles ^a   Yagüe, Ernesto ^a,b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

Biomarker; Minimal residual disease; Oncogenesis; Ras family

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN RPIP9; RAP2 INTERACTING PROTEIN 9; RAS PROTEIN; UNCLASSIFIED DRUG;

ADRENAL GLAND; ARTICLE; BONE MARROW BIOPSY; BRAIN; BREAST BIOPSY; BREAST CARCINOMA; CANCER INVASION; CELL ISOLATION; CELL STRAIN; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE BIOPSY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; TESTIS;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW; BREAST NEOPLASMS; CARRIER PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION; GENES, MDR; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NERVE TISSUE PROTEINS; PROGNOSIS; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 28044436973     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21252     Document Type: Article

References (39)

1. Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med 2002;347:1593-603.
2. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
3. Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer 2004;4:448-56.
4. Schmidt-Kittler O, Ragg T, Daskalakis A, Granzow M, Ahr A, Blankenstein TJ, Kaufmann M, Diebold J, Arnholdt H, Muller P, Bischoff J, Harich D, et al. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci USA 2003;100:7737-42.
5. Sommer S, Fuqua SA. Estrogen receptor and breast cancer. Semin Cancer Biol 2001;11:339-52.
6. Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kindermann G, Riethmuller G, Schlimok G. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000;342:525-33.
7. Woelfle U, Cloos J, Sauter G, Riethdorf L, Janicke F, van Diest P, Brakenhoff R, Pantel K. Molecular signature associated with bone marrow micrometastasis in human breast cancer. Cancer Res 2003;63:5679-84.
8. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, Guise TA, Massague J. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
9. Mansi JL, Gogas H, Bliss JM, Gazet J-C, Berger U, Coombes RC. Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 1999;354:197-202.
10. Nogi H, Takeyama H, Uchida K, Agata T, Horiguchi-Yamada J, Yamada H. Detection of MUC1 and keratin 19 mRNAs in the bone marrow by quantitative RT-PCR predicts the risk of distant metastasis in breast cancer patients. Breast Cancer 2003;10:74-81.
11. Raguz S, Tamburo De Bella M, Tripuraneni G, Slade MJ, Higgins CF, Coombes RC, Yague E. Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion. Clin Cancer Res 2004;10:2776-83.
12. Kothari MS, Ali S, Buluwela L, Livni N, Shousha S, Sinnett HD, Vashisht R, Thorpe P, Van Noorden S, Coombes RC, Slade MJ. Purified malignant mammary epithelial cells maintain hormone responsiveness in culture. Br J Cancer 2003;88:1071-6.
13. Slade MJ, Singh A, Smith BM, Tripuraneni G, Hall E, Peckitt C, Fox S, Graham H, Luchtenborg M, Sinnett HD, Cross NC, Coombes RC. Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: results at 4 years. Int J Cancer 2005;114:94-100.
14. Yague E, Higgins CF, Raguz S. Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1. Gene Ther 2004;11:1170-4.
15. Slade MJ, Smith BM, Sinnett HD, Cross NC, Coombes RC. Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. J Clin Oncol 1999;17:870-9.
16. Wang S, Zhang Z, Ying K, Chen JZ, Meng XF, Yang QS, Xie Y, Mao YM. Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9). Biochem Genet 2003;41:13-25.
17. Chen ZJ, Miao ZH, Vetter M, Dulin N, Liu S, Che D, Hughes B, Murad F, Douglas J, Chang CH. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Biochem Biophys Res Commun 2000;278:106-11.
18. Sommers CL, Byers SW, Thompson EW, Torri JA, Gelmann EP. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat 1994;31:325-35.
19. Veeramachaneni V, Makalowski W, Galdzicki M, Sood R, Makalowska I. Mammalian overlapping genes: the comparative perspective. Genome Res 2004;14:280-6.
20. Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J. Identification of a specific effector of the small GTP-binding protein Rap2. Eur J Biochem 1998;252:290-8.
21. Reuther GW, Der CJ. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol 2000;12:157-65.
22. McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR. The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem 2004;279:12009-19.
23. McLeod SJ, Li AH, Lee RL, Burgess AE, Gold MR. The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration. J Immunol 2002;169:1365-71.
24. Jimenez B, Pizon V, Lerosey I, Beranger F, Tavitian A, de Gunzburg J. Effects of the ras-related rap2 protein on cellular proliferation. Int J Cancer 1991;49:471-9.
25. Singh L, Gao Q, Kumar A, Gotoh T, Wazer DE, Band H, Feig LA, Band V. The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins. J Virol 2003;77:1614-20.
26. Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M. Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol 2000;20:6074-83.
27. Pizon V, Desjardins M, Bucci C, Parton RG, Zerial M. Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex. J Cell Sci 1994;107(Pt 6):1661-70.
28. Trock BJ, Leonessa F, Clarke R. Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance. J Natl Cancer Inst 1997;89:917-31.
29. Bulun SE, Takayama K, Suzuki T, Sasano H, Yilmaz B, Sebastian S. Organization of the human aromatase p450 (CYP19) gene. Semin Reprod Med 2004;22:5-9.
30. Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, et al. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci USA 2003;100:10931-6.
31. Pérou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC, Lashkari D, Shalon D, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 1999;96:9212-7.
32. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
33. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001;98:10869-74.
34. Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci USA 2003;100:10393-8.
35. Evtimova V, Schwirzke M, Tarbe N, Burtscher H, Jarsch M, Kaul S, Weidle UH. Identification of breast cancer metastasis-associated genes by chip technology. Anticancer Res 2001;21:3799-806.
36. Ross DD, Doyle LA. Mining our ABCs: pharmacogenomic approach for evaluating transporter function in cancer drug resistance. Cancer Cell 2004;6:105-7.
37. Klein CA, Blankenstein TJ, Schmidt-Kittler O, Petronio M, Polzer B, Stoecklein NH, Riethmuller G. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002;360:683-9.
38. Mitas M, Mikhitarian K, Walters C, Baron PL, Elliott BM, Brothers TE, Robison JG, Metcalf JS, Palesch YY, Zhang Z, Gillanders WE, Cole DJ. Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer 2001;93:162-71.
39. Bosma AJ, Weigelt B, Lambrechts AC, Verhagen OJ, Pruntel R, Hart AA, Rodenhuis S, van't Veer LJ. Detection of circulating breast tumor cells by differential expression of marker genes. Clin Cancer Res 2002;8:1871-7.