Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3

British Journal of Cancer

Volumn 93, Issue 10, 2005, Pages 1191-1196

  Hughes, S ^a   Damato, B E ^b   Giddings, I ^a   Hiscott, P S ^b   Humphreys, J ^a   Houlston, R S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Array CGH; Regions of imbalance; Uveal melanoma

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 3; CHROMOSOME 6P; CHROMOSOME 6Q; CHROMOSOME 8Q; CHROMOSOME ANALYSIS; CHROMOSOME LOSS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DISOMY; FEMALE; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; MALE; MONOSOMY; PRIORITY JOURNAL; RECURRENT DISEASE; UVEA MELANOMA;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 3; EYE NEOPLASMS; FEMALE; GENOME, HUMAN; HUMANS; MALE; MELANOMA; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 27944511525     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602834     Document Type: Article

References (31)

1. Aalto Y, Eriksson L, Seregard S, Larsson O, Knuutila S (2001) Concomitant loss of chromosome 3 and whole arm losses and gains of chromosome 1, 6, or 8 in metastasizing primary uveal melanoma. Invest Ophthalmol Vis Sci 42: 313-317
2. Beheshti B, Braude I, Marrano P, Thorner P, Zielenska M, Squire JA (2003) Chromosomal localization of DNA amplifications in neuroblastoma tumors using cDNA microarray comparative genomic hybridization. Neoplasia 5: 53-62
3. Bergman L, Seregard S, Nilsson B, Lundell G, Ringborg U, Ragnarsson-Olding B (2003) Uveal melanoma survival in Sweden from 1960-1998. Invest Ophthalmol Vis Sci 44: 2579-2583
4. Douglas EJ, Fiegler H, Rowan A, Halford S, Bicknell DC, Bodmer W, Tomlinson IP, Carter NP (2004) Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res 64: 4817-4825
5. Dunne BM, McNamara M, Clynes M, Shering SG, Larkin AM, Moran E, Barnes C, Kennedy SM (1998) MDR1 expression is associated with adverse survival in melanoma of the uveal tract. Hum Pathol 29: 594-598
6. Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Scott CE, Smith J, Vetrie D, Gorman P, Tomlinson IP, Carter NP (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAG and PAC clones. Genes Chromosomes Cancer 36: 361-374
7. Ghazvini S, Char DH, Kroll S, Waldman FM, Pinkel D (1996) Comparative genomic hybridization analysis of archival formalin-fixed paraffin-embedded uveal melanomas. Cancer Genet Cytogenet 90: 95-101
8. Hendrix MJ, Seftor EA, Seftor RE, Kirschmann DA, Gardner LM, Boldt HC, Meyer M, Pe'er J, Folberg R (1998) Regulation of uveal melanoma interconverted phenotype by hepatocyte growth factor/scatter factor (HGF/SF). Am J Pathol 152: 855-863
9. Hoglund M, Gisselsson D, Hansen GB, White VA, Sall T, Mitelman F, Horsman D (2004) Dissecting karyotypic patterns in malignant melanomas: temporal clustering of losses and gains in melanoma karyotypic evolution. Int J Cancer 108: 57-65
10. Hurks HM, Metzelaar-Blok JA, Barthen ER, Zwinderman AH, De Wolff-Rouendaal D, Keunen JE, Jager MJ (2000) Expression of epidermal growth factor receptor: risk factor in uveal melanoma. Invest Ophthalmol Vis Sci 41: 2023-2027
11. McLean IW, Saraiva VS, Burnier Jr MN (2004) Pathological and prognostic of uveal melanomas. Can J Ophthalmol 39: 343-350
12. Myatt N, Aristodemou P, Neale MH, Foss AJ, Hungerford JL, Bhattacharya S, A Cree I (2000) Abnormalities of the transforming growth factor-beta pathway in ocular melanoma. J Pathol 192: 511-518
13. Nakamura H, Saji H, Idiris A, Kawasaki N, Hosaka M, Ogata A, Saijo T, Kato H (2003) Chromosomal instability detected by fluorescence in situ hybridization in surgical specimens of non-small cell lung cancer is associated with poor survival. Clin Cancer Res 9: 2294-2299
14. Naus NC, van Drunen E, de Klein A, Luyten GP, Paridaens DA, Alers JC, Ksander BR, Beverloo HB, Slater RM (2001) Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization. Genes Chromosomes Cancer 30: 267-273
15. Onken MD, Worley LA, Ehlers JP, Harbour JW (2004) Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res 64: 7205-7209
16. Parrella P, Fazio VM, Gallo AP, Sidransky D, Merbs SL (2003) Fine mapping of chromosome 3 in uveal melanoma: identification of a minimal region of deletion on chromosomal arm 3p25.1-p25.2. Cancer Res 63: 8507-8510
17. Parrella P, Sidransky D, Merbs SL (1999) Allelotype of posterior uveal melanoma: implications for a bifurcated tumor progression pathway. Cancer Res 59: 3032-3037
18. Prescher G, Bornfeld N, Hirche H, Horsthemke B, Jockel KH, Becher R (1996) Prognostic implications of monosomy 3 in uveal melanoma. Lancet 347: 1222-1225
19. Radosevich M, Song Z, Gorga JC, Ksander B, Ono SJ (2004) Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci 45: 3185-3195
20. Scholes AG, Damato BE, Nunn J, Hiscott P, Grierson I, Field JK (2003) Monosomy 3 in uveal melanoma: correlation with clinical and histologic predictors of survival. Invest Ophthalmol Vis Sci 44: 1008-1011
21. Sisley K, Cottam DW, Rennie IG, Parsons MA, Potter AM, Potter CW, Rees RC (1992) Non-random abnormalities of chromosomes 3, 6, and 8 associated with posterior uveal melanoma. Genes Chromosomes Cancer 5: 197-200
22. Sisley K, Rennie IG, Parsons MA, Jacques R, Hammond DW, Bell SM, Potter AM, Rees RC (1997) Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis. Genes Chromosomes Cancer 19: 22-28
23. Stang A, Parkin DM, Ferlay J, Jockel KH (2005) International uveal melanoma incidence trends in view of a decreasing proportion of morphological verification. Int J Cancer 114: 114-123
24. Tschentscher F, Husing J, Holter T, Kruse E, Dresen IG, Jockel KH, Anastassiou G, Schilling H, Bornfeld N, Horsthemke B, Lohmann DR, Zeschnigk M (2003) Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res 63: 2578-2584
25. Tschentscher F, Prescher G, Horsman DE, White VA, Rieder H, Anastassiou G, Schilling H, Bornfeld N, Bartz-Schmidt KU, Horsthemke B, Lohmann DR, Zeschnigk M (2001) Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma. Cancer Res 61: 3439-3442
26. Tschentscher F, Prescher G, Zeschnigk M, Horsthemke B, Lohmann DR (2000) Identification of chromosomes 3, 6, and 8 aberrations in uveal melanoma by microsatellite analysis in comparison to comparative genomic hybridization. Cancer Genet Cytogenet 122: 13-17
27. van der Velden PA, Zuidervaart W, Hurks MH, Pavey S, Ksander BR, Krijgsman E, Frants RR, Tensen CP, Willemze R, Jager MJ, Gruis NA (2003) Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer 106: 472-479
28. Van Ginkel PR, Gee RL, Walker TM, Hu DN, Heizmann CW, Polans AS (1998) The identification and differential expression of calcium-binding proteins associated with ocular melanoma. Biochim Biophys Acta 1448: 290-297
29. White VA, McNeil BK, Horsman DE (1998) Acquired homozygosity (isodisomy) of chromosome 3 in uveal melanoma. Cancer Genet Cytogenet 102: 40-45
30. Wiltshire RN, Elner VM, Dennis T, Vine AK, Trent JM (1993) Cytogenetic analysis of posterior uveal melanoma. Cancer Genet Cytogenet 66: 47-53
31. Zuidervaart W, van der Velden PA, Hurks MH, van Nieuwpoort FA, Out-Luiting CJ, Singh AD, Frants RR, Jager MJ, Gruis NA (2003) Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development. Br J Cancer 89: 1914-1919