Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma

Cancer Research

Volumn 61, Issue 8, 2001, Pages 3439-3442

  Tschentscher, Frank ^a   Prescher, Gabriele ^a   Horsman, Douglas E ^b   White, Valerie A ^c   Rieder, Harald ^d   Anastassiou, Gerasimos ^a   Schilling, Harald ^a   Bornfeld, Norbert ^a   Bartz Schmidt, Karl Ulrich ^e   Horsthemke, Bernhard ^a   Lohmann, Dietmar R ^a   Zeschnigk, Michael ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 3; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME ARM; CHROMOSOME DELETION; COMPARATIVE GENOMIC HYBRIDIZATION; HUMAN; HUMAN TISSUE; KARYOTYPE; MAJOR CLINICAL STUDY; MONOSOMY; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; UVEA MELANOMA;

CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 3; GENES, OVERLAPPING; GENES, TUMOR SUPPRESSOR; HUMANS; KARYOTYPING; LIGASES; MELANOMA; MICROSATELLITE REPEATS; NUCLEIC ACID HYBRIDIZATION; POLYMORPHISM, GENETIC; PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UVEAL NEOPLASMS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0035870290     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Nonrandom chromosomal abnormalities in primary uveal melanoma
2. Cytogenetic findings in six posterior uveal melanomas: Involvement of chromosomes 3, 6 and 8
3. Monosomy 3 and isochromosome 8q in a uveal melanoma
4. Allelotype of posterior uveal melanoma: Implications for a bifurcated tumor progression pathway
5. Prognostic implications of monosomy 3 in uveal melanoma
6. Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis
7. Correlation of cytogenetic abnormalities with the outcome of patients with uveal melanoma
8. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
9. Acquired homozygosity (isodisomy) of chromosome 3 in uveal melanoma
10. Loss of heterozygosity of the thyroid hormone receptor B in posterior uveal melanoma
11. Cytogenetical observations in nine ocular malignant melanomas
12. 3p13 region: A possible location of a tumor suppressor gene involved in uveal melanoma
13. Cytogenetic analysis of uveal melanoma. Consistent occurrence of monosomy 3 and trisomy 8q
14. Chromosomal gains and losses in uveal melanomas detected by comparative genomic hybridization
15. Identification of chromosomes 3, 6, and 8 aberrations in uveal melanoma by microsatellite analysis in comparison to comparative genomic hybridization
16. Comprehensive human genetic maps: Individual and sex-specific variation in recombination
17. Allelotype analysis in osteosarcomas: Frequent allele loss on 3q, 13q, 17p, and 18q
18. Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paraganglioma, suggesting a common genetic etiology
19. Localization of a novel tumor suppressor locus on human chromosome 3q important in osteosarcoma tumorigenesis
20. Combined LOH/CGB analysis proves the existence of interstitial 3p deletions in renal cell carcinoma
21. The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci