Delayed spatial alternation impairments in adult rats following dietary n - 6 deficiency during development

Neurotoxicology and Teratology

Volumn 27, Issue 3, 2005, Pages 485-495

  Roegge, Cindy S ^a   Widholm, John J ^b   Engeseth, Nicki J ^a   Wang, Xiaohong ^a   Brosch, Karl O ^c   Seegal, Richard F ^c   Schantz, Susan L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b School of Business   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

Delayed spatial alternation (DSA); Fatty acid imbalance; Fatty acids (FA); Learning; Memory; n 6 deficiency; n 6 n 3 ratio; Rats

Indexed keywords

OMEGA 6 FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COGNITION; CONFERENCE PAPER; CONTROLLED STUDY; FAT INTAKE; FEMALE; LIPOPHILICITY; MEMORY DISORDER; NEWBORN; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; SPATIAL ORIENTATION; TASK PERFORMANCE; WEANING;

ANIMALS; ANIMALS, NEWBORN; CONDITIONING, OPERANT; CUES; DIET; EATING; FATTY ACIDS; FATTY ACIDS, OMEGA-6; FEMALE; FISH OILS; LEARNING; MALE; MEMORY, SHORT-TERM; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SPACE PERCEPTION;

EID: 20444394066     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2005.02.002     Document Type: Conference Paper

References (32)

1. S.A. Alber, and B.J. Strupp An in-depth analysis of lead effects in a delayed spatial alternation task: assessment of mnemonic effects, side bias, and proactive interference Neurotoxicol. Teratol. 18 1996 3 15
2. E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can. J. Med. Sci. 37 1959 911 917
3. J.-M. Bourre, M. Bonneil, O. Dumont, M. Piciotti, G. Nalbone, and H. Lafont High dietary fish oil alters the brain polyunsaturated fatty acid composition Biochim. Biophys. Acta 960 1988 458 461
4. J.-M. Bourre, M. Bonneil, O. Dumont, M. Piciotti, R. Calaf, H. Portugal, G. Nalbone, and H. Lafont Effect of increasing amounts of dietary fish oil on brain and liver fatty composition Biochim. Biophys. Acta 1043 1990 149 152
5. M. Bubser, and W.J. Schmidt 6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze Behav. Brain Res. 37 1990 157 168
6. S.E. Carlson, and M. Neuringer Polyunsaturated fatty acid status and neurodevelopment: a summary and critical analysis of the literature Lipids 34 1999 171 178
7. S. Chalon, S. Delion-Vancassel, C. Belzung, D. Guilloteau, A.-M. Leguisquet, J.-C. Besnard, and G. Durand Dietary fish oil affects monoaminergic neurotransmission and behavior in rats J. Nutr. 128 1998 2512 2519
8. N. Chetty, S.C. Reavis, A.R. Immelman, P.M. Atkinson, and J.G. van As Fatty acid composition of some South African fresh-water fish S. Afr. Med. J. 76 1989 368 370
9. E.N. Christiansen, J.S. Lund, T. Rortveit, and A.C. Rustan Effect of dietary n - 3 and n - 6 fatty acids on fatty acid desaturation in rat liver Biochim. Biophys. Acta 26 1991 57 62
10. W.E. Connor, M. Neuringer, and S. Reisbick Essential fatty acids: the importance of n - 3 fatty acids in the retina and brain Nutr. Rev. 50 1992 21 29
11. R.A. Gibson The effect of diets containing fish and fish oils on disease risk factors in humans Aust. N. Z. J. Med. 18 1988 713 722
12. R.A. Hites, J.A. Foran, D.O. Carpenter, M.C. Hamilton, B.A. Knuth, and S.J. Schwager Global assessment of organic contaminants in farmed salmon Science 303 2004 226 229
13. R.T. Holman Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids Prog. Lipid Res. 25 1986 29 39
14. M.M. Jensen, T. Skarsfeldt, and C.-E. Hoy Correlation between level of (n - 3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats: a multiple generation study Biochim. Biophys. Acta 1300 1996 203 209
15. G. Keppel Design and Analysis: A Researcher's Handbook Second ed. 1982 Prentice-Hall Englewood Cliffs, NJ
16. W.W.K. Koo Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: can one buy better vision and intelligence? J. Am. Coll. Nutr. 22 2003 101 107
17. V.P. Markowski, C. Cox, R. Preston, and B. Weiss Effects of age and gender but not prenatal cocaine on random ratio and delayed spatial alternation responding in rats Neurotoxicol. Teratol. 22 2000 421 428
18. B.L. Murphy, A.F.T. Arnsten, P.S. Goldman-Rakic, and R.H. Roth Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys Proc. Natl. Acad. Sci. 93 1996 1325 1329
19. H. Okuyama, T. Kobayashi, and S. Watanabe Dietary fatty acids-the n - 6 / n - 3 balance and chronic elderly diseases: excess linoleic acid and relative n - 3 deficiency syndrome seen in Japan Prog. Lipid Res. 35 1997 409 457
20. M. Palkovits, and M.J. Brownstein Maps and Guide to Microdissection of the Rat Brain 1988 Elsevier NY
21. S. Reisbick, and M. Neuringer Omega-3 fatty acid deficiency and behavior S. Yehuda D.I. Mostofsky Handbook of Essential Fatty Acid Biology 1997 Humana Press Totowa, NJ 397 426
22. C.S. Roegge, J.J. Widholm, R.F. Seegal, and S.L. Schantz Task specific learning and memory impairment in offspring of rats fed Pacific Ocean salmon The Toxicologist 60 2001 117
23. S.L. Schantz, B.W. Seo, J. Moshtaghian, R.E. Peterson, and R.W. Moore Effects of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learning Neurotoxicol. Teratol. 18 1996 305 313
24. R.F. Seegal, B. Bush, P. O'Keefe, and W. Shain In vitro neurotoxicology of Great Lakes fish-borne contaminants Great Lakes Res. Rev. 1 1995 31 35
25. R.F. Seegal, R.J. Okoniewski, K.O. Brosch, and J.C. Bemis Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study Environ. Health Perspect. 110 2002 1113 1117
26. P.E. Wainwright Dietary essential fatty acids and brain function: a developmental perspective on mechanisms Proc. Nutr. Soc. 61 2002 61 69
27. P.E. Wainwright, H.-C. Xing, L. Mutsaers, D. McCutcheon, and D. Kyle Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n - 6): (n - 3) ratio and very high levels of docosahexaenoic acid J. Nutr. 127 1997 184 193
28. J.J. Widholm, G.B. Clarkson, B.J. Strupp, K.M. Crofton, R.F. Seegal, and S.L. Schantz Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory control Toxicol. Appl. Pharmacol. 174 2001 188 198
29. J.J. Widholm, S. Villareal, R.F. Seegal, and S.L. Schantz Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats Toxicol. Sci. 2004 (Sept. 29) (Epub ahead of print)
30. C.L. Williams, and W.H. Meck The organizational effects of gonadal steroids on sexually dimorphic spatial ability Psychoneuroendocrinology 16 1991 155 176
31. www.fda.gov.
32. A. Yonekubo, S. Honda, M. Okano, K. Takahashi, and Y. Yamamoto Effects of dietary fish oil during the fetal and postnatal periods on the learning ability of postnatal rats Biosci. Biotechnol. Biochem. 58 1994 799 801