Inhibition of proinflammatory cytokine expression by NF-κB (p65) antisense oligonucleotide in Helicobacter pylori-infected mice

Helicobacter

Volumn 10, Issue 6, 2005, Pages 559-566

  Kim, Sang Gyun ^a   Kim, Joo Sung ^a   Kim, Jung Mogg ^b   Jung, Hyun Chae ^a,c   Song, In Sung ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Antisense oligonucleotide; H. pylori; Interleukin 1 ; Nuclear factor B; Sense oligonucleotide; Tumor necrosis factor

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; POLYCLONAL ANTIBODY; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; GASTROINTESTINAL INFECTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STOMACH MUCOSA; TRANSCRIPTION INITIATION;

ANIMALS; CYTOKINES; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; INTERLEUKIN-1; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; HELICOBACTER; HELICOBACTER PYLORI;

EID: 27944496460     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2005.00365.x     Document Type: Article

References (29)

1. Blaser MJ. The role of Helicobacter pylori in gastritis and its progression to peptic ulcer disease. Aliment Pharmacol Ther 1995;9:27-30.
2. Marshall BJ. Helicobacter pylori. Am J Gastroenterol 1994;89:S116-S128.
3. NIH Consensus Development Panel. Helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-9.
4. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311-5.
5. Crabtree JE. Gastric mucosal inflammatory responses to Helicobacter pylori. Aliment Pharmacol Ther 1996;10:29-37.
6. Jung HC, Kim JM, Song IS, Kim CY. Helicobacter pylori induces an array of proinflammatory cytokines in human gastric epithelial cells: quantification of mRNA for interleukin-8-1α/β granulocyte-macrophage colony stimulating factor, monocyte chemoattractant protein-1 and tumor necrosis factor-α. J Gastroenterol Hepatol 1997;12:473-80.
7. Noach L, Bosma NB, Jansen J, Hoek FJ, Deventer SJ, Tytgat GN. Mucosal tumor necrosis factor-a, interleukin-1, and interleukin-8 production in patients with Helcobacter pylori infection. Scand J Gastroenterol 1994;29:425-9.
8. Ben-Baruch A, Michiel DF, Oppenheim JJ. Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 1996;270:11703-6.
9. Huber AR, Kunkel SL, Todd RF 3rd, Weiss SJ. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 1991;254:99-102.
10. Epstein FH. Nuclear factor-κB-a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71.
11. Keates S, Hitti YS, Upton M, Kelly CP. Helicobacter pylori infection activates NF-κB in gastric epithelial cells. Gastroenterology 1997;113:1099-109.
12. Isomoto H, Mizuta Y, Miyazaki M, Takeshima F, Omagari K, Murase K, Nishiyama T, Inoue K, Murata I, Kohno S. Implication of NF-κB in Helicobacter pylori-associated gastritis. Am J Gastroenterol 2000;95:2768-76.
13. van Den Brink GR, ten Kate FJ, Ponsioen CY, Rive MM, Tytgat GN, van Deventer SJ, Peppelenbosch MP. Expression and activation of NF-κB in the antrum of the human stomach. J Immunol 2000;164:3353-9.
14. Milligan JF, Matteucci MD, Martin JC. Current concepts in antisense drug design. J Med Chem 1993;36:1923-37.
15. Murano M, Maemura K, Hirata I, Toshina K, Nishikawa T, Hamamoto N, Sasaki S, Saitoh O, Katsu K. Therapeutic effect of intracolonically administered nuclear factor κB (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin Exp Immunol 2000;120:51-8.
16. Neurath MF, Pettersson S, Meyer zum Buschenfelde KH, Strober W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat Med 1996;2:998-1004.
17. Kim H, Lim JW, Kim KH. Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-κB. Scand J Gastroenterol 2001;36:706-16.
18. Higgins KA, Perez JR, Coleman TA, Dorshkind K, McComas WA, Sarmiento UM, Rosen CA, Narayanan R. Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression. Proc Natl Acad Sci U S A 1993;90:9901-5.
19. Lee A, O'Rourke J, De Ungria MC, Robertson B, Daskalopoulos G, Dixon MF. A standardized mouse model of Helicobacter pylori infection. Gastroenterology 1997;112:12386-97.
20. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
21. Yamamoto N, Sakagami T, Fukuda Y, Koizuka H, Hori K, Sawada Y, Hikasa Y, Tanida N, Shimoyama T. Influence of Helicobacter pylori infection on development of stress-induced gastric mucosal injury. J Gastroenterol 2000;35:332-40.
22. Kim JM, Kim JS, Jung HC, Oh YK, Kim N, Song IS. Inhibition of Helicobacter pylori-induced nuclear factor-kappa B activation and interleukin-8 gene expression by ecabet sodium in gastric epithelial cells. Helicobacter 2003;8:542-53.
23. Nozawa Y, Nishihara K, Peek RM, Nakano M, Uji T, Ajioka H, Matsuura N, Miyake H. Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem Pharmacol 2002;64:21-30.
24. Shimoyama T, Everett SM, Dixon MF, Axon ATR, Crabtree JE. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J Clin Pathol 1998;51:765-70.
25. Uemura N, Oomoto Y, Mukai T, et al. Gastric corpus IL-8 concentration and neutrophil infiltration in duodenal ulcer patients. Aliment Pharmacol Ther 1997;11:793-800.
26. Kim JS, Jung HC, Kim JM, Song IS, Kim CY. Interleukin-8 expression by human neutrophils activated by H. pylori soluble proteins. Scand J Gastroenterol 1998;33:1249-55.
27. Kim JS, Jung HC, Kim JM, Song IS, Kim CY. Helicobacter pylori water-soluble surface proteins activate human neutrophils and upregulate the expression of CXC chemokines. Dig Dis Sci 2000;45:83-92.
28. Mori N, Krensky AM, Geleziunas R, Wada A, Hirayama T, Sasakawa C, Yamamoto N. Helicobacter pylori induces RANTES through activation of NF-κB. Infect Immun 2003;71:3748-56.
29. Baeuerle PA, Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol 1994;12:141-79.