Alteration in platelet function in patients with early breast cancer

Anticancer Research

Volumn 25, Issue 6 B, 2005, Pages 3963-3966

  McDowell, Garry ^a,b   Temple, I ^b   Li, C ^c   Kirwan, C C ^b   Bundred, N J ^b   McCollum, C N ^b   Burton, I E ^b   Kumar, S ^c   Byrne, G J ^b  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Breast cancer; Platelets; Thrombospondin; Tissue factor; VEGF

Indexed keywords

THROMBIN; THROMBOPLASTIN; THROMBOSPONDIN; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BREAST CANCER; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EARLY CANCER; FEMALE; HUMAN; HUMAN TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE FUNCTION;

AGED; ANIMALS; BLOOD PLATELETS; BREAST NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; CATTLE; HUMANS; MIDDLE AGED; THROMBIN; THROMBOPLASTIN; THROMBOSPONDIN 1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 27944486056     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Trikha M and Nakada MT: Platelets and cancer: implications for antiangiogenic therapy. Semin Thrombo Haemostas 28: 39-44, 2002.
2. Hejna M, Raderer M and Zielinski CC: Inhibition of metastases by anticoagulants. J Natl Cancer Inst 91: 22-36, 1999.
3. Tang DG and Honn KV: Adhesion molecules and tumour metastasis: an update. Invasion Metastasis 14: 109-122, 1994.
4. Young K, Borsig L, Nissi M et al: P-selectin deficiency attenuates tumour growth and metastasis. Proc Natl Acad Sci 95: 9325-9330, 1998.
5. Gasparini G, Toi M, Gion M et al: Prognostic significance of vascular endothelial growth factor in node negative breast carcinoma. J Natl Cancer Inst 89: 139-147, 1997.
6. Ferrara N and Davis-Smyth T: The biology of vascular endothelial growth factor. Endocrine Rev 18: 4-21, 1997.
7. Ferrari G and Scagliotti GV: Serum vascular endothelial growth factor levels in non-small cell lung carcinoma. Eur J Cancer 32A: 2369-2370, 1996.
8. Dirix LY, Vermeulen PB, Pawinski A et al: Elevated levels of angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer 76: 238-243, 1997.
9. Oehler MK and Carrier H: Diagnostic value of serum VEGF in women with ovarian tumours. Anticancer Res 79: 2519-2522, 1999.
10. Mohle R, Green D, Moore MAS, Nachman RL and Rafii S: Constitutive production and thrombin induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci 94: 663-668, 1997.
11. Hayden KE, Tetlow L and Byrne G: Radioimmunoassay for the measurement of thrombospondin in plasma and breast cyst fluid: validation and clinical application. Ann Clin Biochem 37: 319-325, 2000.
12. Adams JA, Carder PJ, Downey S et al: Vascular endothelial growth factor in breast cancer: comparison of plasma, serum and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res 60: 2898-2905, 2000.
13. Salven P, Orpana A and Joensuu H: Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor. Clin Cancer Res 5: 487-491, 1999.
14. Sargiannidou I, Zhou J and Tuszynski GP: The role of thrombospondin-1 in tumour progression. Exp Biol Med 226: 726-733, 2001.
15. Pinedo HM, Verheul HMW, D'Amato RJ and Folkman J: Involvement of platelets in tumour angiogenesis? Lancet 352: 1775-1777, 1998.
16. Blann AD: Angiogenesis and platelets: the clot thickens further. Cardiovasc Res 63: 192-193, 2004.