Embryonic stem cells: Understanding their history, cell biology and signalling

Advanced Drug Delivery Reviews

Volumn 57, Issue 13 SPEC. ISS., 2005, Pages 1894-1903

  Friel, Ruairi ^a   Sar, Sjaak Van Der ^a   Mee, Patrick J ^a  

^a Roger Land Building   (United Kingdom)

Author keywords

Biology; Cell therapy; Drug discovery; Embryonic; History; Review; Signalling; Stem cell; Toxicology

Indexed keywords

BIOLOGICAL MEMBRANES; BIOLOGY; DRUG THERAPY; TISSUE; TOXICITY;

CELL THERAPY; DRUG DISCOVERY; EMBROYNIC; REVIEW; STEM CELL; TOXICOLOGY;

CELL CULTURE;

ALKALINE PHOSPHATASE ISOENZYME; BASIC FIBROBLAST GROWTH FACTOR; BONE MORPHOGENETIC PROTEIN; CYTOKINE; HOMEODOMAIN PROTEIN; INTERLEUKIN 6; JANUS KINASE; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; NANOG PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAGE SPECIFIC EMBRYO ANTIGEN 4; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ANEUPLOIDY; BLASTOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; CELL RENEWAL; CELL STIMULATION; CELL STRUCTURE; CELL TYPE; EMBRYONIC STEM CELL; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; TERATOCARCINOMA; TOTIPOTENT STEM CELL; TRANSCRIPTION INITIATION;

EID: 27944478942     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2005.08.002     Document Type: Review

References (45)

1. G.R. Martin, and M.J. Evans Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro Proc. Natl. Acad. Sci. U. S. A. 72 1975 1441 1445
2. G. Martin Teratocarcinomas and mammalian embryogenesis Science 209 1980 768 776
3. M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotent cells from mouse embryos Nature 292 1981 154 156
4. G. Martin Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc. Natl. Acad. Sci. U. S. A. 78 1981 7634 7638
5. A.G. Smith, and M.L. Hooper Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonic carcinoma and embryonic stem cells Dev. Biol. 12 1987 1 9
6. A. Smith, J.K. Heath, D.D. Donaldson, G.G. Wong, J. Moreau, M. Stahl, and D. Rogers Inhibition of pluripotent embryonic stem cell differentiation by purified polypeptides Nature 336 1988 688 690
7. R.L. Williams, D.J. Hilton, S. Pease, T.A. Wilson, C.L. Stewart, D.P. Gearing, E.F. Wagner, D. Metcalf, N.A. Nicola, and M.M. Gough Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells Nature 336 1988 684 687
8. J. Nichols, I. Chambers, T. Taga, and A. Smith Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines Development 128 2001 2333 2339
9. S. Davis, T.H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N.Y. Ip, and G.D. Yancopoulos LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor Science 260 1993 1805 1808
10. K. Yoshida, I. Chambers, J. Nichols, A. Smith, M. Saito, K. Yasukawa, M. Shoyab, T. Taga, and T. Kishimoto Maintenance of the pluripotent phenotype of embryonic stem cells through direct activation of gp130 signalling pathways Mech. Dev. 45 1994 163 171
11. H. Niwa, T. Burdon, I. Chambers, and A. Smith Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 Genes Dev. 12 1998 2048 2060
12. M. Ernst, U. Novak, S.E. Nicholson, J.E. Layton, and A.R. Dunn The carboxyl terminal domains of gp130 related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3 J. Biol. Chem. 274 1999 9729 9737
13. T. Matsuda, T. Nakamura, K. Nakao, T. Arai, M. Katsuki, T. Heike, and T. Yokota STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells EMBO J. 18 1999 4261 4269
14. W. Kolch Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Biochem. J. 351 2000 289 305
15. M. Takahashi-Tezuka, Y. Yoshida, T. Fukada, T. Ohanti, Y. Yamanaka, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase Mol. Cell. Biol. 18 1998 4109 4117
16. T. Burdon, C. Stracey, I. Chambers, J. Nichols, and A. Smith Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells Dev. Biol. 210 1999 30 43
17. A.M. Cheng, T.M. Saxton, R. Sakai, S. Kulkarni, G. Mbamalu, W. Vogel, C.G. Tortorice, R.D. Cardiff, J.C. Cross, W.J. Muller, and T. Pawson Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation Cell 95 1998 793 803
18. T. Burdon, I. Chambers, C. Stracey, H. Niwa, and A. Smith Signalling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells Cells Tissues Organs 165 1999 131 143
19. M. Pesce, M.K. Gross, and H. Scholer In line with our ancestors: Oct-4 and the mammalian germ BioEssays 20 1998 722 732
20. Y.I. Yeom, D. Fuhrmann, C.E. Ovitt, A. Brehm, K. Ohbo, M. Gross, K. Hubner, and H.R. Scholer Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells Development 122 1996 881 894
21. J. Nichols, B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius, I. Chambers, H. Schöler, and A. Smith Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 Cell 95 1998 379 391
22. H. Niwa, J.-I. Mijazaki, and A.G. Smith Quantitative expression of Oct3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Nat. Genet. 24 2000 372 376
23. A.A. Avilion, S.K. Nicolis, L.H. Pevny, N. Vivian, and R. Lovell-Badge Multipotent cell lineages in early mouse development depend on sox2 function Genes Dev. 17 2003 126 140
24. L.A. Hanna, R.K. Foreman, I.A. Tarasenko, D.S. Kessler, and P.A. Labosky Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo Genes Dev. 16 2002 2650 2661
25. Y. Guo, R. Costa, H. Ramsey, T. Starnes, G. Vance, K. Robertson, M. Kelley, R. Reinbold, H. Scholer, and R. Hromas The embryonic stem cell transcription factors Oct4 and FoxD3 interact to regulate endodermal-specific promoter expression Proc. Natl. Acad. Sci. U. S. A. 99 2002 3663 3667
26. H. Yuan, N. Corbi, C. Basilico, and L. Dailey Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3 Genes Dev. 9 1995 2635 2645
27. C.N. Berger, and K.S. Strum Self renewal of embryonic stem cells in the absence of feeder cells and exogenous leukaemia inhibitory factor Growth Factors 14 1997 145 159
28. C. Dani, I. Chambers, S. Johnstone, M. Robertson, B. Ebrahimi, M. Saito, T. Taga, M. Li, T. Burdon, J. Nichols, and A. Smith Panacrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway Dev. Biol. 203 1998 149 162
29. I. Chambers, D. Colby, M. Robertson, J. Nichols, S. Lee, S. Tweedie, and A. Smith Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells Cell 113 2003 643 655
30. K. Mitsui, Y. Tokuzawa, H. Itoh, K. Segawa, M. Murakami, K. Takahashi, M. Maruyama, M. Maeda, and S. Yamanaka The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and es cells Cell 113 2003 631 642
31. A.H. Hart, L. Hartley, M. Ibrahim, and L. Robb Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human Dev. Dyn. 230 2004 187 198
32. K. Ogawa, H. Matsui, S. Ohtsuka, and H. Niwa A novel mechanism for regulating clonal propagation of mouse ES cells Genes Cells 9 2004 471 477
33. Q.-L. Ying, J. Nichols, I. Chambers, and A. Smith BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 Cell 115 2003 281 292
34. P.A. Wilson, and A. Hemmati-Brianlou Induction of epidermis and inhibition of neural fate by Bmp-4 Nature 376 1995 331 333
35. Q.-L. Ying, M. Stavridis, D. Griffiths, M. Li, and A. Smith Conversion of embryonic stem cells to neuroectodermal precursors in adherent monolayers Nat. Biotechnol. 21 2003 183 186
36. B.M. Johansson, and M.V. Wiles Evidence for involvement of activin A and bone morphogenic protein 4 in mammalian mesoderm and hematopietic development Mol. Cell. Biol. 15 1995 141 151
37. E. Canalis, A.N. Economides, and E. Gazzerro Bone morphogenic proteins, their antagonists, and the skeleton Endocr. Rev. 24 2003 218 235
38. J.D. Norton ID helix-loop-helix proteins in cell growth, differentiation, and tumorigenesis J. Cell. Sci. 113 2000 3897 3905
39. Y. Jen, H. Weintraub, and R. Benezra Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins Genes Dev. 6 1992 1466 1479
40. K. Nakashima, M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, M. Kawabata, K. Miyazono, and T. Taga Synergistic signalling in fetal brain by STAT3-Smad1 complex bridged by p300 Science 284 1999 479 482
41. Y. Sun, M. Nadal-Vincens, S. Misono, M.Z. Lin, A. Zubiaga, X. Hua, G. Fan, and M.E. Greenberg Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms Cell 104 2001 365 376
42. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
43. C. Xu, M.S. Inokumi, J. Denbham, K. Golds, P. Kundu, J.D. Gold, and M.K. Carpenter Feeder-free growth of undifferentiated human embryonic stem cells Nat. Biotechnol. 19 2001 971 974
44. M. Richards, C.Y. Fong, W.K. Chan, P.C. Wong, and A. Bongso Human feeders support growth of human inner cell masses and embryonic stem cells Nat. Biotechnol. 20 2002 933 936
45. J.J. Tarin, and A. Cano Do human concepti have the potential to enter into diapause? Hum. Reprod. 14 1999 2434 2436