RPTLC determination of the lipophilicity of some new N-[(4-arylpiperazin-1-yl)alkyl] spirosuccinimides

Journal of Planar Chromatography - Modern TLC

Volumn 18, Issue 105, 2005, Pages 384-387

  Obniska, Jolanta ^a   Kamińska, Krzysztof ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Anticonvulsant activity; Lipophilicity; N (4 arylpiperazin 1 yl)alykl 2 azaspiro 4.4 nonane and 4.5 decane 1,3 dione; RPTLC; Spirosuccinimides

Indexed keywords

CORRELATION METHODS; EXTRAPOLATION; MIXTURES; MOLECULAR STRUCTURE; MOLECULES; PHARMACODYNAMICS; SILICA GEL;

ACTIVE ANTICONVULSANTS; LIPOPHILICITY; REVERSED PHASE THIN LAYER CHROMATOGRAPHY; SPIROSUCCINIMIDES;

THIN LAYER CHROMATOGRAPHY;

ANTICONVULSIVE AGENT; BUFFER; N [(4 ARYLPIPERAZIN 1 YL)ALKYL] 2 AZASPIRO[4.4]NONANE DERIVATIVE; N [(4 ARYLPIPERAZIN 1 YL)ALKYL] 2 AZASPIRO[4.5]DECANE 1,3 DIONE DERIVATIVE; N [(4 ARYLPIPERAZIN 1 YL)ALKYL]SPIROSUCCINIMIDE DERIVATIVE; PROPANOL; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; CALCULATION; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; LIPOPHILICITY; REVERSED PHASE THIN LAYER CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

EID: 27944443704     PISSN: 09334173     EISSN: None     Source Type: Journal    
DOI: 10.1556/JPC.18.2005.5.10     Document Type: Article

References (22)

1. T. Sławik and C. Kowalski, J. Chromatogr. A 952 (2002) 295-299.
2. K. Takács-Novák, P. Perjési, and J. Vámos, J. Planar Chromatogr. 14 (2001) 42-46.
3. B. Hallgas, T. Patonay, A. Kiss-Szikszai, Zs. Dobos, F. Hollósy, D. Eross, L. Orfi, Gy. Kéri, and M. Idei, J. Chromatogr. B 801 (2004) 229-235.
4. N.U. Perišic-Janjić, M.M. Ačanski, N.J. Janjić, M.D. Lazarević, and V. Dimova, J. Planar Chromatogr. 13 (2000) 281-284.
5. C. Sârbu, D. Casoni, M. Darabantu, and C. Maiereanu, J. Pharm. Biomed. Anal. 35 (2004) 213-219.
6. F. Hollósy, T. Lóránd, L. Orfi, D. Eros, Gy. Kéri, and M. Idei, J. Chromatogr. B 768 (2002) 361-368.
7. F. Hollósy, J. Seprodi, L. Orfi, D. Eros, Gy. Kéri, and M. Idei, J. Chromatogr. B 780 (2002) 355-363.
8. J. Obniska and K. Kamiński, J. Planar Chromatogr. 18 (2005) 240-243.
9. J. Obniska, personal communication.
10. J. Obniska, M. Kołaczkowski, S. Charakchieva-Minol, K. Nedza, M. Dybała, and A. J. Bojarski, Pharmacol. Rep. 57 (2005) 336-344.
11. J. Obniska and A. Zagórska, Il Farmaco 58 (2003) 1227-1234.
12. J. Obniska, K. Kulig, and A. Zejc, Acta Polon. Pharm. - Drug Res. 55(3) (1998) 223-231.
13. J. Obniska, M. Pawłowski, M. Kołaczkowski, A. Czopek, B. Duszyńska, A. Kłodzińska, et al. Pol. J. Pharmacol. 55 (2003) 553-557.
14. J. Obniska, K. Kamiński, and E. Tatarczyńska, Pharmacol. Rep. (2005) submitted for publication.
15. R.L. Krall, J.K. Penry, B.G. White, H.J. Kupferberg, and E.A. Swinyard, Epilepsia. 19 (1978) 409-428.
16. H.J. Kupferberg, Epilepsia. 30 (suppl.) (1989) 51-56.
17. J.K. Seydel and K.J. Schaper, Chemische Struktur und biologische Aktivitat von Wirkstoffen. Methoden der quantitativen Struktur-Wirkung-Analyse, Verlag Chemie, Weinheim, 1979, p. 259.
18. E. Tomlinson, J. Chromatogr. 113 (1975) 1-45.
19. Statistica version 5, 1997 edn, Statsoft, 1984-1997.
20. J. Obniska, A. Zejc, and A. Zagórska, Acta Polon. Pharm.- Drug Res. 59 (2002) 209-213.
21. J. Obniska, A. Zejc, and J. Karolak-Wojciechowska, Il Farmaco 54 (1999) 423-429.
22. Pallas version 3.0, CompuDrug, 1994-1999.