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Volumn 768, Issue 2, 2002, Pages 361-368
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Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test
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Author keywords
Hydrophobicity; Mannich ketones
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Indexed keywords
KETONES;
LIPOPHILICITY;
CHROMATOGRAPHY;
3 (4,5 DIMETHYLTHIAZOL 2 YL) 2,5 DIPHENYL TETRAZOLIUM BROMIDE;
BROMINE DERIVATIVE;
KETONE DERIVATIVE;
MORPHOLINE;
PIPERIDINE;
TETRAHYDROISOQUINOLINE DERIVATIVE;
UNCLASSIFIED DRUG;
ADENOCARCINOMA;
ANALYTIC METHOD;
ANTINEOPLASTIC ACTIVITY;
APOPTOSIS;
ARTICLE;
CALCULATION;
CANCER CELL CULTURE;
CANCER INHIBITION;
COMPUTER PROGRAM;
CONTROLLED STUDY;
CYTOTOXICITY TEST;
DRUG CYTOTOXICITY;
DRUG EFFECT;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN CELL;
LIPOPHILICITY;
MOLECULAR LIBRARY;
PREDICTION;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
ANTINEOPLASTIC AGENTS;
APOPTOSIS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
KETONES;
LIPID METABOLISM;
TUMOR CELLS, CULTURED;
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EID: 0037022726
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/S1570-0232(02)00004-1 Document Type: Article |
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Times cited : (38)
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References (30)
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