Hydrocortisone in septic shock: Too much, too little, too soon?

Critical Care Medicine

Volumn 33, Issue 11, 2005, Pages 2683-2684

  Thys, Frédéric ^a   Laterre, Pierre Francois ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Adrenal function; Cytokine; Hemodynamics; Hydrocortisone; Organ failure; Sepsis; Shock; Steroids

Indexed keywords

HLA D ANTIGEN; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; PLACEBO;

ADRENAL DISEASE; BACTERIUM CONTAMINATION; CARDIOPULMONARY HEMODYNAMICS; CYTOKINE PRODUCTION; DISEASE DURATION; DOSE CALCULATION; DRUG EFFECT; DRUG RESEARCH; DRUG SAFETY; EDITORIAL; HOSPITAL INFECTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; IMMUNE RESPONSE; INFECTION COMPLICATION; LOW DRUG DOSE; MEDICAL ASSESSMENT; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 27944433389     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000186891.90994.01     Document Type: Editorial

References (12)

1. Annane D, Sébille V, Troché G, et al: A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283:1038-1045
2. Hamrahian AH, Oseni TS, Arafah BM: Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004; 350:1629-1638
3. Bond RF: Peripheral vascular adrenergic depression during hypotension induced by E. coli endotoxin. Adv Shock Res 1983; 9:157-169
4. Bond RF, Scott CG, Clevenger JC, et al: Effect of systemic endotoxin on muscle vascular conductance during high and low adrenergic tone. Circ Shock 1990; 30:311-322
5. Annane D, Bellissant E, Sébille V, et al: Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998; 46:589-597
6. Bollaert P-E, Charpentier C, Levy B, et al: Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998; 26:645-650
7. Briegel J, Forst H, Haller M, et al: Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27:723-732
8. Annane D, Sébille V, Charpentier C, et al: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-871
9. Keh D, Boehnke T, Weber-Cartens S, et al: Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: A double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167:512-520
10. Briegel J, Jochum M, Gippner-Steppert C, et al: Immunomodulation in septic shock: Hydrocortisone differentially regulates cytokine responses. J Am Soc Nephrol 2001; 12:S70-S74
11. Marik PE, Gayowski T, Starzl TE: The hepatoadrenal syndrome: A common yet unrecognized clinical condition. Crit Care Med 2005; 33:1254-1259
12. Oppert M, Schindler R, Husung C, et al: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005; 33:2457-2464