Older age independently predicts a lower risk of sentinel lymph node metastasis in breast cancer

Annals of Surgical Oncology

Volumn 12, Issue 12, 2005, Pages 1061-1065

  Caywood, Jason ^a   Gray, Richard J ^a   Hentz, Joseph ^a   Pockaj, Barbara A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Breast cancer; Elderly; Neoplasm metastasis; Sentinel node

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER INVASION; CANCER SURGERY; DATA BASE; DISEASE ASSOCIATION; FEMALE; HISTOLOGY; HUMAN; LOGISTIC REGRESSION ANALYSIS; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; PREDICTION; RISK ASSESSMENT; SENTINEL LYMPH NODE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM INVASIVENESS; RISK FACTORS; SENTINEL LYMPH NODE BIOPSY;

EID: 27844552287     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/ASO.2005.02.013     Document Type: Article

References (19)

1. Hutchins LF, Unger JM, Crowle JJ, Coltoman CA, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999;341:2061-7.
2. Clark RM, Whelan T, Levine M, et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 1996;88:1659-64.
3. Fisher B, Dignam J, Wolmark N, et al. Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer. J Natl Cancer Inst 1997;89:1673-82.
4. Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomized trials. Lancet 1998;351:1451-67.
5. Silliman RA. What constitutes optimal care for older women with breast cancer?. J Clin Oncol 2003;21:3554-6.
6. O'Connell JB, Maggard MA, Ko CY. Cancer-directed surgery for localized disease: decreased use in the elderly. Ann Surg Oncol 2004;11:962-9.
7. Edge SB, Gold K, Berg CD, et al. Outcomes and preferences for treatment in older women nationwide study research team. Patient and provider characteristics that affect the use of axillary dissection in older women with stage I-II breast carcinoma. Cancer 2002;94:2534-41.
8. Blanchard DK, Donohue JH, Reynolds C, Grant CS. Relapse and morbidity in patients undergoing sentinel lymph node biopsy alone or with axillary dissection for breast cancer. Arch Surg 2003;138:482-7; discussion 487-8.
9. McMasters KM, Wong SL, Edwards MJ, et al. Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma. Surgery 2001;130:151-6.
10. Gray RJ, Pockaj BA, Conley CR. Sentinel lymph node metastases detected by immunohistochemistry only do not mandate complete axillary lymph node dissection in breast cancer. Ann Surg Oncol 2004;11:1056-60.
11. Morrow M, White J, Moughan J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol 2001;19:2254-62.
12. Yancik R, Wesley MN, Ries LA, Havlik RJ, Edwards BK, Yates JW. Effect of age and comorbidity in postmenopausal breast cancer patients aaed 55 years and older. JAMA 2001;285:885-92.
13. Madnelblatt JS, Hadley J, Kerner JF, et al. Patterns of breast carcinoma treatment in older women: patient preferences and clinical and physician influences. Cancer 2000;89:561-73.
14. Hebert-Croteau N, Brisson J, Latreille J, Blanchette C, Deschenes L. Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women. Cancer 1999;84:1104-13.
15. DiFronzo LA, Hansen NM, Stern SL, Brennan MB, Giuliano AE. Does sentinel lymphadenectomy improve staging and alter therapy in elderly women with breast cancer?. Ann Surg Oncol 2000;7:406-10.
16. Singh R, Hellman S, Heimann R. The natural history of breast carcinoma in the elderly: implications for screening and treatment. Cancer 2004;100:1807-13.
17. Velanovich V, Szymanski W. Lymph node metastasis in breast cancer: common prognostic markers lack predictive value. Ann Surg Oncol 1998;5:613-9.
18. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001;19:3622-34.
19. Hughes KS, Schnaper LA, Berry D, et al. Cancer and Leukemia Group B. Radiation Therapy Oncology Group. Eastern Cooperative Oncology Group. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004;351:971-7.