-
1
-
-
0024958651
-
Arthritis induced by continuous infusion of hr-interleukin-1 alpha into the rabbit knee-joint
-
Feige U, Karbowski A, Rordorf-Adam C, et al. (1989) Arthritis induced by continuous infusion of hr-interleukin-1 alpha into the rabbit knee-joint. Int J Tissue React 11, 225-38.
-
(1989)
Int J Tissue React
, vol.11
, pp. 225-238
-
-
Feige, U.1
Karbowski, A.2
Rordorf-Adam, C.3
-
2
-
-
0023694150
-
Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
-
Eastgate JA, Symons JA, Wood NC, et al. (1988) Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 2, 706-9.
-
(1988)
Lancet
, vol.2
, pp. 706-709
-
-
Eastgate, J.A.1
Symons, J.A.2
Wood, N.C.3
-
3
-
-
17444394445
-
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
-
Bresnihan B, Alvaro-Gracia JM, Cobby M, et al. (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41, 2196-204.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2196-2204
-
-
Bresnihan, B.1
Alvaro-Gracia, J.M.2
Cobby, M.3
-
4
-
-
0036190776
-
Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
-
Cohen S, Hurd E, Cush J, et al. (2002) Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46, 614-24.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 614-624
-
-
Cohen, S.1
Hurd, E.2
Cush, J.3
-
5
-
-
3442885115
-
A multicenter, double blind, randomized, placebo controlled trial of anakinra (Kineret), and recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate
-
Cohen SB, Moreland LW, Cush JJ, et al. (2004) A multicenter, double blind, randomized, placebo controlled trial of anakinra (Kineret), and recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate. Ann Rheum Dis 63, 1062-8.
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 1062-1068
-
-
Cohen, S.B.1
Moreland, L.W.2
Cush, J.J.3
-
6
-
-
0034083128
-
A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores
-
Jiang Y, Genant HK, Watt I, et al. (2000) A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 43, 1001-9.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1001-1009
-
-
Jiang, Y.1
Genant, H.K.2
Watt, I.3
-
7
-
-
2542505865
-
Anakinra safety experience: Infection results from a long-term safety study and postmarketing experience
-
Veith J, Wallis WJ, Modafferi D, et al. (2003) Anakinra safety experience: Infection results from a long-term safety study and postmarketing experience. Ann Rheum Dis 62, 191.
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 191
-
-
Veith, J.1
Wallis, W.J.2
Modafferi, D.3
-
8
-
-
2642576804
-
The safety of anakinra in high-risk patients with active rheumatoid arthritis: Six-month observations of patients with comorbid conditions
-
Schiff MH, DiVittorio G, Tesser J, et al. (2004) The safety of anakinra in high-risk patients with active rheumatoid arthritis: six-month observations of patients with comorbid conditions. Arthritis Rheum 50, 1752-60.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1752-1760
-
-
Schiff, M.H.1
DiVittorio, G.2
Tesser, J.3
-
9
-
-
0001419395
-
Safety of combination therapy with anakinra and etanercept in patients with rheumatoid arthritis
-
Schiff MH, Bulpitt K, Weaver AA, et al. (2001) Safety of combination therapy with anakinra and etanercept in patients with rheumatoid arthritis. Arthritis Rheum 44, S79.
-
(2001)
Arthritis Rheum
, vol.44
-
-
Schiff, M.H.1
Bulpitt, K.2
Weaver, A.A.3
-
10
-
-
2342551979
-
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
-
Genovese M, Cohen S, Moreland L, et al. (2004) Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 50, 1412-9.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1412-1419
-
-
Genovese, M.1
Cohen, S.2
Moreland, L.3
-
12
-
-
2542492560
-
An evaluation of the use of anakinra by rheumatoid arthritis patients previously treated with a TNF inhibitor
-
Schiff MH, Keystone EC, Gibofsky A, et al. (2003) An evaluation of the use of anakinra by rheumatoid arthritis patients previously treated with a TNF inhibitor. Ann Rheum Dis 62, 186.
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 186
-
-
Schiff, M.H.1
Keystone, E.C.2
Gibofsky, A.3
-
13
-
-
5044223401
-
Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis
-
Verbsky JW, White AJ (2004) Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. J Rheumatol 31, 2071-5.
-
(2004)
J Rheumatol
, vol.31
, pp. 2071-2075
-
-
Verbsky, J.W.1
White, A.J.2
-
14
-
-
14944387115
-
Treatment of systemic onset juvenile rheumatoid arthritis with anakinra
-
Irigoyen PI, Olson J, Hom C, et al. (2004) Treatment of Systemic Onset Juvenile Rheumatoid Arthritis with anakinra. Arthritis Rheum 50, S437.
-
(2004)
Arthritis Rheum
, vol.50
-
-
Irigoyen, P.I.1
Olson, J.2
Hom, C.3
-
15
-
-
20044391732
-
A twelve-week open label safety and efficacy study of anakinra (Kineret) in juvenile rheumatoid arthritis
-
Ilowite NT, Porras O, Reiff A, et al. (2003) A twelve-week open label safety and efficacy study of anakinra (Kineret) in juvenile rheumatoid arthritis. Ann Rheum Dis 62, 87.
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 87
-
-
Ilowite, N.T.1
Porras, O.2
Reiff, A.3
-
16
-
-
0026537579
-
Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arhtritis
-
Dasgupta B, Corkill M, Kirkham B, et al. (1992) Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arhtritis. J Rheumatol 19, 22-5.
-
(1992)
J Rheumatol
, vol.19
, pp. 22-25
-
-
Dasgupta, B.1
Corkill, M.2
Kirkham, B.3
-
17
-
-
13344250490
-
Interleukin 6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
-
Kotake S, Sato K, Kim KJ, et al. (1996) Interleukin 6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11, 88-95.
-
(1996)
J Bone Miner Res
, vol.11
, pp. 88-95
-
-
Kotake, S.1
Sato, K.2
Kim, K.J.3
-
18
-
-
0033393367
-
Interleukin 6 knockout mice are resistant to antigen-induced experimental arthritis
-
Boe A, Baiocchi M, Carbonatto M, et al. (1999) Interleukin 6 knockout mice are resistant to antigen-induced experimental arthritis. Eur Cytokine Netw 11, 1057-64.
-
(1999)
Eur Cytokine Netw
, vol.11
, pp. 1057-1064
-
-
Boe, A.1
Baiocchi, M.2
Carbonatto, M.3
-
19
-
-
0032429668
-
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
-
Takagi N, Mihara M, Moriya Y, et al. (1998) Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 41, 2117-21.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2117-2121
-
-
Takagi, N.1
Mihara, M.2
Moriya, Y.3
-
20
-
-
0035090840
-
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
-
Mihara M, Kotah M, Nishimoto N, et al. (2001) Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 98, 319-26.
-
(2001)
Clin Immunol
, vol.98
, pp. 319-326
-
-
Mihara, M.1
Kotah, M.2
Nishimoto, N.3
-
21
-
-
0027402917
-
Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody
-
Wendling D, Racadot E, Wijdenses J (1993) Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody. J Rheumatol 20, 259-62.
-
(1993)
J Rheumatol
, vol.20
, pp. 259-262
-
-
Wendling, D.1
Racadot, E.2
Wijdenses, J.3
-
22
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomised, double-blind, placebo-controlled, dose-escalation trial
-
Choy EH, Isenberg DA, Garrood T, et al. (2002) Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomised, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 46, 3143-50.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
-
23
-
-
10044279965
-
Efficacy of IL6 receptor antagonist MRA in rheumatoid arthritis patients with an incomplete response to methotrexate (CHARISMA)
-
Maini RN, Taylor PC, Pavelka K, et al. (2003) Efficacy of IL6 receptor antagonist MRA in rheumatoid arthritis patients with an incomplete response to methotrexate (CHARISMA). Arthritis Rheum 48, S652.
-
(2003)
Arthritis Rheum
, vol.48
-
-
Maini, R.N.1
Taylor, P.C.2
Pavelka, K.3
-
24
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody
-
Nishimoto N, Yoshizaki K, Miyasaka N, et al. (2004) Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 50, 1761-9.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
25
-
-
0032103993
-
Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
-
Ruchatz H, Leung BP, Wei XQ, et al. (1998) Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol 160, 5654-60.
-
(1998)
J Immunol
, vol.160
, pp. 5654-5660
-
-
Ruchatz, H.1
Leung, B.P.2
Wei, X.Q.3
-
26
-
-
6344269986
-
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
-
Ferrari-Lacraz S, Zanelli E, Neuberg M, et al. (2004) Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 173, 5818-26.
-
(2004)
J Immunol
, vol.173
, pp. 5818-5826
-
-
Ferrari-Lacraz, S.1
Zanelli, E.2
Neuberg, M.3
-
27
-
-
27844434121
-
A novel human monoclonal antibody against IL-15 (HuMax-15) in patients with active rheumatoid arthritis (RA): Results of a double-blind, placebo-controlled phase I/II trial
-
Baslund B, Tvede N, Danneskiold-Samsoe B, et al. (2003) A novel human monoclonal antibody against IL-15 (HuMax-15) in patients with active rheumatoid arthritis (RA): results of a double-blind, placebo-controlled phase I/II trial. Arthritis Rheum 48, S653.
-
(2003)
Arthritis Rheum
, vol.48
-
-
Baslund, B.1
Tvede, N.2
Danneskiold-Samsoe, B.3
-
28
-
-
14844289358
-
Safety and efficacy of a human monoclonal antibody to IL15 (AMG 714) in patients with rheumatoid arthritis (RA): Results from a multicenter, randomized, double-blind, placebo-controlled trial
-
McInnes I, Martin R, Zimmerman-Gorska I, et al. (2004) Safety and efficacy of a human monoclonal antibody to IL15 (AMG 714) in patients with rheumatoid arthritis (RA): results from a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 50, S241.
-
(2004)
Arthritis Rheum
, vol.50
-
-
McInnes, I.1
Martin, R.2
Zimmerman-Gorska, I.3
-
29
-
-
0029849012
-
Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: Requirement for both B7-1 and B7-2
-
Webb LMC, Walmesley MJ, Feldmann M (1996) Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur J Immunol 26, 2320-8.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2320-2328
-
-
Webb, L.M.C.1
Walmesley, M.J.2
Feldmann, M.3
-
30
-
-
0036275436
-
Costimulatory blockade in patients with rheumatoid arthritis. A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4 and LEA29Y eighty-five days after the first infusion
-
Moreland LW, Alten R, Van den Bosch F, et al. (2002) Costimulatory blockade in patients with rheumatoid arthritis. A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4 and LEA29Y eighty-five days after the first infusion. Arthritis Rheum 46, 1470-9.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1470-1479
-
-
Moreland, L.W.1
Alten, R.2
Van Den Bosch, F.3
-
31
-
-
0242574700
-
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4-Ig
-
Kremer JM, Westhovens R, Leon M, et al. (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4-Ig. N Eng J Med 349, 1907-15.
-
(2003)
N Eng J Med
, vol.349
, pp. 1907-1915
-
-
Kremer, J.M.1
Westhovens, R.2
Leon, M.3
-
32
-
-
0035093233
-
Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
-
Edwards JCW, Cambridge G (2001) Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 41, 205-11.
-
(2001)
Rheumatology (Oxford)
, vol.41
, pp. 205-211
-
-
Edwards, J.C.W.1
Cambridge, G.2
-
33
-
-
0036676817
-
Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis
-
De Vita S, Zaja F, Sacco S, et al. (2002) Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis. Arthritis Rheum 46, 2029-33.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2029-2033
-
-
De Vita, S.1
Zaja, F.2
Sacco, S.3
-
34
-
-
2942537697
-
Efficacy of B-cell targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards JCW, Szczepanski L, Szechiriski J, et al. (2004) Efficacy of B-cell targeted therapy with rituximab in patients with rheumatoid arthritis. N Eng J Med 350, 2572-81.
-
(2004)
N Eng J Med
, vol.350
, pp. 2572-2581
-
-
Edwards, J.C.W.1
Szczepanski, L.2
Szechiriski, J.3
|