Anti-inflammatory acylphloroglucinol derivatives from hops (Humulus lupulus)

Journal of Natural Products

Volumn 68, Issue 10, 2005, Pages 1545-1548

  Bohr, Gregor ^a   Gerhäuser, Clarissa ^b   Knauft, Jutta ^b   Zapp, Josef ^a   Becker, Hans ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYLBUTYRYL)PHLOROGLUCINOL GLUCOPYRANOSIDE; 1 (2 METHYLPROPANOYL)PHLOROGLUCINOL GLUCOPYRANOSIDE; 1 (3 METHYLBUTYRYL)PHLOROGLUCINOL GLUCOPYRANOSIDE; 1 [(2 METHYLBUTYRYL)PHLOROGLUCINYL] BETA DEXTRO GLUCOPYRANOSIDE; 1 [(2 METHYLPROPANOYL)PHLOROGLUCINYL] BETA DEXTRO GLUCOPYRANOSIDE; 1 [(3 METHYLBUTYRYL)PHLOROGLUCINYL] BETA DEXTRO GLUCOPYRANOSIDE; 5 (2 METHYLPROPANOYL)PHLOROGLUCINOL GLUCOPYRANOSIDE; 5 [(2 METHYLBUTYRYL)PHLOROGLUCINYL] BETA DEXTRO GLUCOPYRANOSIDE; ACID; AGLYCONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; DIMETHYL SULFOXIDE; GLUCOPYRANOSIDE; GLUCOSIDE; HUMULUS LUPULUS EXTRACT; NATURAL PRODUCT; PHLOROGLUCINOL; PHLOROGLUCINOL DERIVATIVE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOPS; HUMULUS LUPULUS; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MEDICINAL PLANT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; GLUCOSIDES; HUMULUS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHLOROGLUCINOL; PLANTS, MEDICINAL;

HUMULUS LUPULUS;

EID: 27844516012     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np050164z     Document Type: Article

References (25)

1. Stevens, J. F.; Miranda, C. L.; Buhler, D. R.; Deinzer, M. L. J. Am. Soc. Brew. Chem. 1998, 56, 136-145.
2. Chadwick, L. R.; Nikolic, D.; Burdette, J. E.; Overk, C. R.; Bolton, J. L.; Van Breemen, R. B.; Fröhlich, R.; Fong, H. H. S.; Farnsworth, N. R.; Pauli, G. F. J. Nat. Prod. 2004, 67, 2024-2032.
3. Stevens, J. F.; Miranda, C. L.; Wolthers, K. R.; Schimerlik, M.; Deinzer, M. L.; Buhler, D. R. J. Agric. Food Chem. 2002, 50, 3435-3443.
4. Taylor, A. W.; Barofsky, E.; Kennedy, J. A.; Deinzer, M. L. J. Agric. Food Chem. 2003, 51, 4101-4110.
5. Verzele, M. J. Inst. Brew. 1986, 92, 32-48.
6. Mizobuchi, S.; Sato, Y. Agric. Biol. Chem. 1985, 49, 399-403.
7. Stavri, M.; Schneider, R.; O'Donnell, G.; Lechner, D.; Bucar, F.; Gibbons, S. Phytother. Res. 2004, 18, 774-776.
8. Gerhäuser, C. Eur. J. Cancer (Special Issue) 2005 (doi: 10.1016/j.ejca. 2005.04.012).
9. Stevens, J. F.; Page, J. E. Phytochemistry 2004, 65, 1317-1330.
10. Gerhäuser, C.; Alt, A.; Heiss, E.; Gamal-Eldeen, A.; Klimo, K.; Knauft, J.; Neumann, I.; Scherf, H. R.; Frank, N.; Bartsch, H.; Becker, H. Mol. Cancer Ther. 2002, 1, 959-969.
11. Zhao, F.; Watanabe, J.; Nozawa, H.; Daikonnya, A.; Kondo, K.; Kitanaka, S. J. Nat. Prod. 2005, 68, 43-49.
12. Kosasi, S.; Van der Sluis, W. G.; Labadie, R. P. Phytochemistry 1989, 28, 2439-2441.
13. Vancraenenbroeck, R.; Vanclef, A.; Lontie, R. Proc. 10th Congr. EBC, Stockholm, 1965; pp 360-370.
14. Tsukamoto, S.; Tomise, K.; Aburatani, M.; Onuki, H.; Hirorta, H.; Ishiharajima, E.; Ohta, T. J. Nat. Prod. 2004, 67, 1839-1841.
15. Fung, S. Y.; Brusse, J.; Van Der Hoeven, R. A. M.; Niessen, W. M. A.; Scheffer, J. J. C. J. Nat. Prod. 1994, 57, 452-459.
16. Zuurbier, K. W. M.; Fung S. Y.; Scheffer J. J. C.; Verpoorte, R. Phytochemistry 1995, 38, 77-82.
17. Zuurbier, K. W. M.; Fung S. Y.; Scheffer J. J. C.; Verpoorte, R. Phytochemistry 1998, 49, 2315-2322.
18. Paniego, N. B.; Zuurbier, K. W. M.; Fung, S. Y.; Van Der Heijden, R.; Scheffer J. J. C.; Verpoorte, R. Eur. J. Biochem. 1999, 262, 612-616.
19. Carl, H. Hops and Hop Products (manual of good practice); EBC Technology and Engineering Forum Nürnberg, 1997; pp 67-68.
20. Gerhauser, C.; Klimo, K.; Heiss, E.; Neumann, I.; Gamal Eldeen, A.; Knauft, J.; Liu, G. Y.; Sitthimonchai, S.; Frank, N. Mutat. Res. 2003, 523-524, 163-172.
21. Fitzpatrick, F. A. Curr. Pharm. Des. 2004, 10, 577-588.
22. Garavito, R. M.; Mulichak, A. M. Annu. Rev. Biophys. Biomol. Struct. 2003, 32, 183-206.
23. Albert, D.; Zundorf, I.; Dingermann, T.; Muller, W. E.; Steinhilber, D.; Werz, O. Biochem. Pharmacol. 2002, 64, 1767-1775.
24. Szewczuk, L. M.; Penning, T. M. J. Nat Prod. 2004, 67, 1777-1782.
25. Szewczuk, L. M.; Forti, L.; Stivala, L. A.; Penning, T. M. J. Biol. Chem. 2004, 279, 22727-22737.