Cinchona derivatives as bifunctional organocatalysts for the direct asymmetric nitroaldol (Henry) reaction

Synlett

Volumn , Issue 18, 2005, Pages 2817-2819

  Marcelli, Tommaso ^a   Van Der Haas, Richard N S ^a   Van Maarseveen, Jan H ^a   Hiemstra, Henk ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Asymmetric organocatalysis; Bifunctional catalysis; Cinchona alkaloids; Nitroalcohols; Nitroaldol reaction

Indexed keywords

ALDEHYDE; CINCHONA EXTRACT;

ALDOL REACTION; ARTICLE; BAYLIS HILLMAN REACTION; CATALYSIS; CATALYST; ENANTIOMER; ENANTIOSELECTIVITY; ROOM TEMPERATURE; STEREOCHEMISTRY;

EID: 27844510491     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-918935     Document Type: Article

References (22)

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22. In ref. 5 the ee reported for 1a is 81% in the preliminary studies and 78% for a preparative run after work-up and chromatography. This corresponds approximately to the same loss of optical purity we experienced.