Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits

Cell Research

Volumn 15, Issue 5, 2005, Pages 387-393

  Wang, Lei Ming ^a,c   Yan, Ye ^b   Zou, Liang Jian ^a   Jing, Nai He ^b   Xu, Zhi Yun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c No 85 Hospital of PLA   (China)

Author keywords

Apoptosis; Hypothermia; Ischemia; Spinal cord

Indexed keywords

DNA FRAGMENT; PROTEIN BCL 2; PROTEIN P53;

ANIMAL; APOPTOSIS; ARTICLE; CRYOANESTHESIA; GENETICS; HUMAN; METABOLISM; NECROSIS; NERVE CELL; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; RABBIT; SPINAL CORD ISCHEMIA; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; DNA FRAGMENTATION; HUMANS; HYPOTHERMIA, INDUCED; IN SITU NICK-END LABELING; NECROSIS; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; SPINAL CORD ISCHEMIA; TUMOR SUPPRESSOR PROTEIN P53;

ORYCTOLAGUS CUNICULUS;

EID: 27844472934     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290306     Document Type: Article

References (30)

1. Cambria RP, Clouse WD, Davison JK, et al. Thoracoabdominal aneurysm repair: Results with 337 operations performed over a 15-year interval. Ann Surg 2002; 236:471-9.
2. Moore WM, Jr., Hollier LH. The influence of severity of spinal cord ischemia in the etiology of delayed-onset paraplegia. Ann Surg 1991; 213:427-31.
3. Mackey ME, Wu Y, Hu R, et al. Cell death suggestive of apoptosis after spinal cord ischemia in rabbits. Stroke 1997; 28:2012-7.
4. Sakurai M, Hayashi T, Abe K, Sadahiro M, Tabayashi K. Delayed and selective motor neuron death after transient spinal cord ischemia: A role of apoptosis? J Thorac Cardiovasc Surg 1998; 115:1310-5.
5. Hayashi T, Sakurai M, Abe K, et al. Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke 1998; 29:1007-12.
6. Sakurai M, Hayashi T, Abe K, et al. Cyclin d1 and cdk4 protein induction in motor neurons after transient spinal cord ischemia in rabbits. Stroke 2000; 31:200-7.
7. Matsushita K, Wu Y, Qiu J, et al. Fas receptor and neuronal cell death after spinal cord ischemia. J Neurosci 2000; 20:6879-87.
8. Cambria RP, Davison JK, Zannetti S, et al. Clinical experience with epidural cooling for spinal cord protection during thoracic and thoracoabdominal aneurysm repair. J Vasc Surg 1997; 25:234-41.
9. Martelli E, Cho JS, Mozes G, Gloviczki P. Epidural cooling for the prevention of ischemic injury to the spinal cord during aortic occlusion in a rabbit model: Determination of the optimal temperature. J Vasc Surg 2002; 35:547-53.
10. Busto R, Globus MY, Dietrich WD, et al. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 1989; 20:904-10.
11. Bossenmeyer-Pourie C, Koziel V, Daval JE. Effects of hypothermia on hypoxia-induced apoptosis in cultured neurons from developing rat forebrain: Comparison with preconditioning. Pediatr Res 2000; 47:385-91.
12. Phanithi PB, Yoshida Y, Santana A, et al. Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: Immunohistochemical study of fas, caspase-3 and tunel. Neuropathology 2000; 20:273-82.
13. Jacobs TP, Kempski O, McKinley D, et al. Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia. Stroke 1987; 23:367-73
14. rd edition. Isolation of high-molecular-weight DNA from mammalian cells using Proteinase K and phenol. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY 2001:463-71.
15. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993; 24:2002-8.
16. Qin XQ, Sun XH, Luo ZQ. Vasoactive intestinal peptide and epidermal growth factor upregulates bcl-2 gene expression in bronchial epithelial cells. Sheng Li Xue Bao 1999; 51:419-24.
17. Ning XH, Chen SH, Xu CS, et al. Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol 2002; 92:2200-7.
18. Yan Q, Sage EH. Transforming growth factor-beta1 induces apoptotic cell death in cultured retinal endothelial cells but not pericytes: association with decreased expression of p21waf1/cip1. J Cell Biochem 1998; 70:70-83.
19. Wyllie A. Cell death: A new classification separating apoptosis from necrosis. In: Bowen ID LR, ed. Cell death in biology and pathology. Chapman and Hall: London, England 1981:9-34.
20. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407:770-6.
21. Lin R, Roseborough G, Dong Y, Williams GM, Wei C. DNA damage and repair system in spinal cord ischemia. J Vasc Surg 2003; 37:847-58.
22. Maier CM, Ahern K, Cheng ME,et al. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: Effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke 1998; 29:2171-80.
23. Kil HY, Zhang J, Piantadosi CA. Brain temperature alters hydro xyl radical production during cerebral ischemia/reperfusion in rats. J Cereb Blood Flow Metab 1996; 16:100-6.
24. Zhang Z, Sobel RA, Cheng D, Steinberg GK, Yenari MA. Mild hypothermia increases bcl-2 protein expression following global cerebral ischemia. Brain Res Mol Brain Res 2001; 95:75-85.
25. Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab 2002; 22:21-8.
26. Li Y, Chopp M, Zhang ZG, et al. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 1994; 25:849-55.
27. Hata R, Gillardon F, Michaelidis TM, Hossmann KA. Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab Brain Dis 1999; 14:117-24.
28. Antonawich FJ, Federoff HJ, Davis JN. Bcl-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp Neurol 1999; 156:130-7.
29. Martinou JC, Dubois-Dauphin M, Staple JK, et al. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994; 13:1017-30.
30. Zhao H, Yenari MA, Sapolsky RM, Steinberg GK. Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome c release. Stroke 2004; 35:572-7.