Mass spectrometry and the search for moonlighting proteins

Mass Spectrometry Reviews

Volumn 24, Issue 6, 2005, Pages 772-782

  Jeffery, Constance J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Moonlighting proteins; Multifunctional; Proteomics

Indexed keywords

CELL TYPES; MOONLIGHTING PROTEINS; MULTIPROTEIN COMPLEXES; ORGANELLES;

BIOCHEMISTRY; BIOTECHNOLOGY; CELLS; CYTOLOGY; PROTEINS;

MASS SPECTROMETRY;

PROTEIN;

ARTICLE; CHEMISTRY; GENE EXPRESSION PROFILING; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PROTEIN ANALYSIS; PROTEOMICS; STRUCTURE ACTIVITY RELATION;

GENE EXPRESSION PROFILING; MASS SPECTROMETRY; PROTEIN INTERACTION MAPPING; PROTEINS; PROTEOMICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27844471239     PISSN: 02777037     EISSN: None     Source Type: Journal    
DOI: 10.1002/mas.20041     Document Type: Article

References (48)

1. Barker DP, Campbell AM. 1981. Genetic and biochemical characterization of the birA gene and its product: Evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli. J Mol Biol 146:469-492.
2. Ben-Yehuda S, Dix I, Russel CS, McGarvey M, Beggs JD, Kupiec M. 2000. Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156:1503-1517.
3. Benliname N, Le PU, Nabi IR. 1998. Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum. Mol Biol Cell 9:1773-1786.
4. Bolduc JM, Spiegel PC, Chatterjee P, Brady KL, Downing ME, Caprara MC, Waring RB, Stoddard, BL. 2003. Structural and biochemical analysis of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev 17:2875-2888.
5. Brix K, Summa W, Lottspeich F, Herzog V. 1998. Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages. J Clin Invest 102:283-293.
6. Caprara MG, Mohr G, Lambowitz AM. 1996. A tyrosyl-tRNA synthetase protein induces tertiary folding of the group I intron catalytic core. J Mol Biol 257:512-531.
7. Cascalho M, Wong J, Steinberg C, Wabl M. 1998. Mismatch repair co-opted by hypermutation. Science 279:1207-1210.
8. Chen J-W, Dodia C, Feinstein SI, Jain MK, Fisher AB. 2000. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem 275:28421-28427.
9. Chu E, Koeller DM, Casey JL, Drake JC, Chabner BA, Elwood PC, Zinn S, Allegra CJ. 1991. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci USA 88:8977-8981.
10. Citron BA, Davis MD, Milstien S, Gutierrez J, Mendel DB, Crabtree GR, Kaufman S. 1992. Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. Proc Natl Acad Sci USA 89:11891-11894.
11. Crennell S, Takimoto T, Portner A, Taylor G. 2000. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat Struct Biol 7:1068-1074.
12. Darwiche N, Freeman LA, Strunnikov A. 1999. Characterization of the components of the putative mammalian sister chromatid cohesion complex. Gene 233:39-47.
13. Fearnley IM, Carroll J, Shannon RJ, Runswick MJ, Walker JE, Hirst J. 2001. GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:Ubiquinone oxidoreductase (complex I). J Biol Chem 276:38345-38348.
14. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S-I. 1992. Angiogenic factor. Nature 356:668.
15. Gonzalez F, Delahodde A, Kodadek T, Johnstom SA. 2002. Recruitment of a 19S proteasome subcomplex to an activated promoter. Science 296:548-550.
16. Guo GG, Gu M, Etlinger JD. 1994. 240-kDa proteasome inhibitor (CF-2) is identical to delta-aminolevulinic acid dehydratase. J Biol Chem 269:12399-12402.
17. Gurney ME, Apatoff BR, Spear GT, Baumel MJ, Antel JP, Bania MB, Reder AT. 1986a. Neuroleukin: A lymphokine product of lectin-stimulated T cells. Science 234:574-581.
18. Gurney ME, Heinrich SP, Lee MR, Yin HS. 1986b. Molecular cloning and expression of neuroleukin, neurotrophic factor for spinal and sensory neurons. Science 234:566-74.
19. Heikkinen J, Risteli M, Chunguag W, Latvala J, Rossi M, Valtavaara M, Myllyla R. 2000. Lysyl hydroxylase 3 is a multifunctional protein posessing collagen glucosyltransferase activity. J Biol Chem 275:36158-36163.
20. Jan Y, Matter M, Pai J, Chen Y-L, Pilch J, Komatsu M, Ong E, Fukuda M, Ruoslahti E. 2004. A mitchondrial protein, bill, mediates apoptosis regulated by integrals and groucho/TLE corepressorss. Cell 116:751-762.
21. Jeffery CJ. 1999. Moonlighting proteins. Trends Biochem Sci 24:8-11.
22. Jeffery CJ. 2003. Multifunctional proteins: Examples of gene sharing. Ann Med 35:28-35.
23. Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA. 1999. Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry 39:955-964.
24. Kennedy MC, Mende-Mueller L, Blondin GA, Beiner H. 1992. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc Natl Acad Sci USA 89:11730-11734.
25. Lay AJ, Jiang X-M, Kisker O, Flynn E, Underwood A, Condron R, Hogg PJ. 2000. Phosphoglycerase kinase acts in tumour angiogenesis as a disulphide reductase. Nature 408:869-873.
26. Mark DF, Richardson CC. 1976. Escherichia coli thioredoxin: A subunit of bacteriophage T7 DNA polymerase. Proc Natl Acad Sci USA 73:780-784.
27. Modun B, Morrissey J, Williams P. 2000. The staphylococcal transferrin receptor: A glycolytic enzyme with novel functions. Trends Microbiol. 8:231-237.
28. Mowbray SL, Koshland DE, Jr. 1990. Mutations in the aspartate receptor of Escherichia coli which affect aspartate binding. J Biol Chem 265:15638-15643.
29. Multiple Leiomyoma Consortium 2002. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nature Genetics 30:406-410.
30. Numata O. 1996. Multifunctional proteins in Tetrahymena: 14-nm filament protein/citrate synthase and translation elongation factor-1 alpha. Int Rev Cytol 164:1-35.
31. Ostrovsky de Spicer P, Maloy S. 1993. PutA protein, a membrane-associated flavin dehydrogenase, acts as a redox-dependent transcriptional regulator. Proc Natl Acad Sci USA 90:4295-4298.
32. Piatigorsky J. 1998. Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Ann NY Acad Sci 842:7-15.
33. Picot D, Loll PJ, Garavito RM. 1994. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature 367:243-249.
34. Pitarch A, Sanchez M, Nombela C, Gil C. 2002. Sequential fractionation and two-dimensional gel analysis unravels the complexity of the dimorphic fungus Candida albicans cell wall proteome. Mol Cell Proteomics 1:967-982.
35. Russell CS, Ben-Yehuda S, Dix I, Kupiec M, Beggs JD. 2000. Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. RNA 6:1565-1572.
36. Searls DB. 2003. Pharmacophylogenomics: Genes, evolution and drug targets. Nat Rev Drug Discov 2:613-623.
37. Soker S, Takashim S, Miao HQ, Neufeld G, Klagsbrun M. 1998. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92:735-745.
38. Stallmeyer B, Schwarz G, Schulze J, Nerlich A, Reiss J, Kirsch J, Mendel RR. 1999. The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc Natl Acad Sci USA 96:1333-1338.
39. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. 1995. CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847-850.
40. Suzuki CK, Rep M, Maarten van Dijl J, Suda K, Grivell LA, Schatz G. 1997. ATP-dependent proteases that also chaperone protein biogenesis. Trends Biochem Sci 22:118-123.
41. Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J, Flohe L. 1999. Dual function of the selenoprotein PHGPx during sperm maturation. Science 285:1393-1396.
42. Watanabe H, Takehana K, Date M, Shinozaki T, Raz A. 1996. Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide. Cancer Res 56:2960-2963.
43. Wolff C, Parkinson JS. 1988. Aspartate taxis mutants of the Escherichia coli tar chemoreceptor. J Bacteriol 170:4509-4515.
44. Wool IG. 1996. Extraribosomal functions of ribosomal proteins. Trends Biochem Sci 21:164-165.
45. Wu RR, Couchman JR. 1997. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: A five domain structure including coiled-coil motifs. J Cell Biol 136:433-444.
46. Xu W, Seiter K, Feldman E, Ahmed T, Chiao JW. 1996. The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase. Blood 87:4502-4506.
47. Young JD, Lawrence AJ, Maclean AG, Leung BP, Mclnnes IB, Canas B, Pappin DJC, Stevenson RD. 1999. Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nat Med 5:1424-1427.
48. Zhu W, Rainville IR, Ding M, Bolus M, Heintz NH, Pederson DS. 2002. Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. Genetics 160:1319-1333.