Middle molecule removal in low-flux polysulfone dialyzers: Impact of flows and surface area on whole-body and dialyzer clearances

Hemodialysis International

Volumn 9, Issue 4, 2005, Pages 399-408

  Eloot, Sunny ^a   de Vos, Jean Yves ^b   de Vos, Filip ^c   Hombrouckx, Remi ^b   Verdonck, Pascal ^a  

^a GHENT UNIVERSITY   (Belgium)

^b Dialysis Unit   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Clearance; Dialyzer; In parallel; In series; Middle molecule; Whole body

Indexed keywords

CYANOCOBALAMIN; DIALYSIS FLUID; POLYSULFONE;

ARTICLE; ARTIFICIAL KIDNEY; BLOOD FLOW; BLOOD SAMPLING; BLOOD SUBSTITUTION; BODY SURFACE; CALCULATION; CLEARANCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVICE; DIALYSATE; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR WEIGHT; MOLECULE; SOLUTE; ULTRAFILTRATION;

HEMODIALYSIS SOLUTIONS; MEMBRANES, ARTIFICIAL; MODELS, THEORETICAL; POLYMERS; RENAL DIALYSIS; SULFONES;

EID: 27744590872     PISSN: 14927535     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1492-7535.2005.01159.x     Document Type: Article

References (46)

1. Sargent JA. Shortfalls in the delivery of dialysis. Am J Kidney Dis. 1990; 15:500-510.
2. Eknoyan G, Beck GJ, Cheung AK, Daugirdas JT, Greene T, Kusek JW, Allon M, Bailey J, Delmez JA, Depner TA, Dwyer JT, Levey AS, Levin NW, Milford E, Ornt DB, Rocco MV, Schulman G, Schwab SJ, Teehan BP, Toto R. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002; 347:2010-2019.
3. Koda Y, Nishi S, Miyazaki S, Haginoshita S, Sakurabayashi T, Suzuki M, Sakai S, Yuasa Y, Hirasawa Y, Nishi T. Switch from conventional to high-flux membrane reduces the risk of carpal tunnel syndrome and mortality of hemodialysis patients. Kidney Int. 1997; 52:1096-1101.
4. Woods HF, Nandakumar M. Improved outcome for haemodialysis patients treated with high-flux membranes. Nephrol Dial Transplant. 2000; 15(suppl 1):36-42.
5. Leypoldt JK, Cheung AK, Carroll CE, Stannard DC, Pereira BJ, Agodoa LY, Port FK. Effect of dialysis membranes and middle molecule removal on chronic hemodialysis patient survival. Am J Kidney Dis. 1999; 33:349-355.
6. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jorres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W. Review on uremic toxins: Classification, concentration, and interindividual variability. Kidney Int. 2003; 63:1934-1943.
7. Babb AL, Popovich RP, Christopher TG, Scribner BH. The genesis of the square meter-hour hypothesis. Trans Am Soc Artif Intern Organs. 1971; 17:81-91.
8. Cheung AK. Quantitation of dialysis. The importance of membrane and middle molecules. Blood Purif. 1994; 12:42-53.
9. Mandolfo S, Malberti F, Imbasciati E, Cogliati P, Gauly A. Impact of blood and dialysate flow and surface on performance of new polysulfone hemodialysis dialyzers. Int J Artif Organs. 2003; 26:113-120.
10. Granger A, Vantard G, Vantelon J, Perrone B. A mathematical approach of simultaneous dialysis and filtration (SDF). Proc Eur Soc Artif Organs. 1978; 5:174-177.
11. Green DM, Antwiler GD, Moncrief JW, Decherd JF, Popovich RP. Measurement of the transmittance coefficient spectrum of Cuprophan and RP69 membranes: Applications to middle molecule removal via ultrafiltration. Trans Am Soc Artif Intern Organs. 1976; 22:627-636.
12. Werynski A. Evaluation of the impact of ultrafiltration on dialyzer clearance. Artif Organs. 1979; 3:140-142.
13. Jaffrin MY, Ding LH, Laurent JM. Simultaneous convective and diffusive mass transfers in a hemodialyser. J Biomech Eng. 1990; 112:212-219.
14. Werynski A, Waniewski J. Theoretical description of mass transport in medical membrane devices. Artif Organs. 1995; 19:420-427.
15. Daugirdas JT, Depner TA. A nomogram approach to hemodialysis urea modeling. Am J Kidney Dis. 1994; 23:33-40.
16. Sargent JA, Gotch FA. Principles and biophysics of dialysis. In: Jacobs C, Kjellstrand CM, Koch KM, Winchester JF, eds. Replacement of Renal Function by Dialysis. Dordrecht: Kluwer Academic Publisher; 1996:34-102.
17. Vander Velde C, Leonard EF. Theoretical assessment of the effect of flow maldistributions on the mass transfer efficiency of artificial organs. Med Biol Eng Comput. 1985; 23:224-229.
18. Clark WR, Rocco MV, Collins AJ. Quantification of hemodialysis: Analysis of methods and the relevance to patient outcome. Blood Purif. 1997; 15:92-111.
19. Clark WR, Leypoldt JK, Henderson LW, Mueller BA, Scott MK, Vonesh EF. Quantifying the effect of changes in the hemodialysis prescription on effective solute removal with a mathematical model. J Am Soc Nephrol. 1999; 10:601-609.
20. Maasrani M, Jaffrin MY, Fischbach M, Boudailliez B. Urea, creatinine and phosphate kinetic modeling during dialysis: Application to pediatric hemodialysis. Int J Artif Organs. 1995; 18:122-129.
21. Schneditz D, Daugirdas JT. Compartment effects in hemodialysis. Semin Dial. 2001; 14:271-277.
22. Eloot S, Torremans A, De Smet R, Marescau B, De Wachter D, De Deyn PP, Lameire N, Verdonck P, Vanholder R. Kinetic behavior of urea is different from that of other water-soluble compounds: The case of the guanidino compounds. Kidney Int. 2005; 67:1566-1575.
23. Eloot S, De Vos JY, Hombrouckx R, Verdonck P. Diffusive clearance of small and middle-sized molecules in combined dialyzer flow configurations. Int J Artif Organs. 2004; 27:205-213.
24. Powers KM, Wilkowski MJ, Helmandollar AW, Koenig KG, Bolton WK. Improved urea reduction ratio and Kt/V in large hemodialysis patients using two dialyzers in parallel. Am J Kidney Dis. 2000; 35:266-274.
25. Fritz BA, Doss S, McCann LM, Wrone EM. A comparison of dual dialyzers in parallel and series to improve urea clearance in large hemodialysis patients. Am J Kidney Dis. 2003; 41:1008-1015.
26. Henderson LW, Clark WR, Cheung AK. Quantification of middle molecular weight solute removal in dialysis. Semin Dial. 2001; 14:294-299.
27. Allen R, Frost TH, Hoenich NA. The influence of the dialysate flow rate on hollow fiber hemodialyzer performance. Artif Organs. 1995; 19:1176-1180.
28. Leypoldt JK, Cheung AK, Agodoa LY, Daugirdas JT, Greene T, Keshaviah PR. Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates: The hemodialysis (HEMO) study. Kidney Int. 1997; 51:2013-2017.
29. Leypoldt JK. Solute fluxes in different treatment modalities. Nephrol Dial Transplant. 2000; 15(suppl 1):3-9.
30. Hauk M, Kuhlmann MK, Riegel W, Kohler H. In vivo effects of dialysate flow rate on Kt/V in maintenance hemodialysis patients. Am J Kidney Dis. 2000; 35:105-111.
31. Sigdell JE, Tersteegen B. Clearance of a dialyzer under varying operating conditions. Artif Organs. 1986; 10: 219-225.
32. Ronco C, Brendolan A, Crepaldi C, Rodighiero M, Everard P, Ballestri M, Cappelli G, Spittle M, La Greca G. Dialysate flow distribution in hollow fiber hemodialyzers with different dialysate pathway configurations. Int J Artif Organs. 2000; 23:601-609.
33. Clark WR, Shinaberger JH. Effect of dialysate-side mass transfer resistance on small solute removal in hemodialysis. Blood Purif. 2000; 18:260-263.
34. Hoenich NA, Frost TH. influence of design and operating variables on conventional haemodialysis. In: Whelpton D, ed. Renal Dialysis. London: Sector Publishing; 1974:85-104.
35. Osuga T, Obata T, Ikehira H, Tanada S, Sasaki Y, Naito H. Dialysate pressure isobars in a hollow-fiber dialyzer determined from magnetic resonance imaging and numerical simulation of dialysate flow. Artif Organs. 1998; 22:907-909.
36. Ronco C, Scabardi M, Goldoni M, Brendolan A, Crepaldi C, La Greca G. Impact of spacing filaments external to hollow fibers on dialysate flow distribution and dialyzer performance. Int J Artif Organs. 1997; 20:261-266.
37. Zhang J, Parker DL, Leypoldt JK. Flow distribution in hollow fiber hemodialysers using magnetic resonance Fourier velocity imaging. ASAIO J. 1995; 41:M678-M682.
38. Legallais C, Catapano G, von Harten B, Baurmeister U. A theoretical model to predict the in vitro performance of hemodiafilters. J Membr Sci. 2000; 168:3-15.
39. Ronco C, Ghezzi PM, Brendolan A, Crepaldi C, La Greca G. The haemodialysis system: Basic mechanisms of water and solute transport in extracorporeal renal replacement therapies. Nephrol Dial Transplant. 1998; 13(suppl 6): 3-9.
40. Jaffrin MY. Convective mass transfer in hemodialysis. Artif Organs. 1995; 19:1162-1171.
41. Dellanna F, Wuepper A, Baldamus CA. Internal filtration - advantage in haemodialysis? Nephrol Dial Transplant. 1996; 11(suppl 2):83-86.
42. Sato Y, Mineshima M, Ishimori I, Kaneko I, Akiba T, Teraoka S. Effect of hollow fiber length on solute removal and quantification of internal filtration rate by Doppler ultrasound. Int J Artif Organs. 2003; 26:129-134.
43. Bosch T, Schmidt B, Samtleben W, Gurland HJ. Effect of protein adsorption on diffusive and convective transport through polysulfone membranes. Contrib Nephrol. 1985; 46:14-22.
44. Eloot S, De Wachter D, Vienken J, Pohlmeier R, Verdonck R In vitro evaluation of the hydraulic permeability of polysulfone dialysers. Int J Artif Organs. 2002; 25:210-216.
45. Leypoldt JK, Cheung AK. Characterization of molecular transport in artificial kidneys. Artif Organs. 1996; 20: 381-389.
46. Scott JM. Bioavailability of vitamin B12. Eur J Clin Nutr. 1997; 51(suppl 1):S49-S53.