Framework for environmental exposure research: The disease-first approach

Molecular Interventions

Volumn 5, Issue 5, 2005, Pages 262-267

  Wilson, Samuel H ^a   Suk, William A ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NIEHS Superfund Basic Research Program

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MARKER;

ACUTE DISEASE; CARCINOMA; CARDIOVASCULAR DISEASE; CHRONIC LUNG DISEASE; DEVELOPING COUNTRY; DIABETES MELLITUS; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EXPERIMENTAL ANIMAL; GENE INTERACTION; GENE VECTOR; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOMICS; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE DELIVERY; HEALTH STATUS; HEREDITY; HIGH THROUGHPUT SCREENING; LABORATORY TEST; MEDICAL INFORMATICS; MEDICAL RESEARCH; METABOLOMICS; PATHOPHYSIOLOGY; PHARMACOLOGICAL SCIENCE; POPULATION RESEARCH; PREVALENCE; PROTEOMICS; PUBLIC HEALTH SERVICE; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; THEORETICAL MODEL; TREATMENT PLANNING; UNITED STATES; XENOBIOTIC METABOLISM;

DISEASE SUSCEPTIBILITY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; HEALTH STATUS; HUMANS; INFORMATION SYSTEMS; POPULATION SURVEILLANCE; RESEARCH; RISK ASSESSMENT;

EID: 27744561884     PISSN: 15340384     EISSN: None     Source Type: Journal    
DOI: 10.1124/mi.5.5.1     Document Type: Review

References (39)

1. World Health Organization. The World Health Report 2003 - Shaping the Future. Geneva, Switzerland, World Health Organization (2003).
2. Yach, D., Hawkes, C., Gould, C.L., and Hofman, K.J. The global burden of chronic diseases. J. Am. Med. Assoc. 291, 2616-2622 (2004).
3. Briggs, D. Environmental pollution and the global burden of disease. Br. Med. J. 68, 1-24 (2003).
4. Institute of Medicine. Rebuilding the Unity of Health and the Environment, A New Vision of Environmental Health for the 21st Century - A Workshop Summary for the Roundtable on Environmental Health Sciences, Research, and Medicine. National Academy Press, Washington, DC, 79 pp (2001).
5. U.S. Department of Health and Human Services. Healthy People 2010 (conference Edition). Washington, DC (January 2000/ www.health.gov/ healthypeople).
6. Mullan, R.J. and Murthy, L.I. Occupational sentinel health events: An updated list for physician recognition and public health surveillance. Am. J. Ind. Med. 19, 775-799 (1991).
7. Goldman, L. and Coussens, C.M. (eds.). Environmental Health Indicators: Bridging the Chasm of Public Health and the Environment. Washington, DC, National Academies Press (2004).
8. Pew Environmental Health Commission. America's Environmental Health Gap: Why the Country Needs a Nationwide Health Tracking Network. Baltimore, MD, Johns Hopkins School of Public Health (Sept. 2000). Pew Charitable Trusts Grantee Report (http://www.pewtrusts.com/pubs/pubs_item.cfm?content_item_id= 539&content_type_id=8&page=p1).
9. Lioy, P.J. Exposure analysis: Reflections on its growth and aspirations for its future. J. Expo. Anal. Environ. Epidemiol. 9, 273-281 (1999).
10. Brindle, J.T., Antti, H., Holmes, E., et al. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1 h-NMR-based metabonomics. Nat. Med. 8, 1439-1444 (2002).
11. Chung, C., Bernard, P.S., and Perou, C.M. Molecular portraits and the family tree of cancer. Nat. Genet. Suppl 32, 535-540 (2002).
12. Orchard, S., Taylor, C.F., Hermjakob, H., et al. Advances in the development of common interchange standards for proteomic data. Proteomics 4, 2363-2365 (2004).
13. Omenn, G.S. The Human Proteome Organization Plasma Proteome Project pilot phase: Reference specimens, technology platform comparisons, and standardized data submissions and analyses. Proteomics 4, 1235-1240 (2004).
14. Kitano, H. Biological robustness. Nat. Rev. Genet. 5, 826-837 (2004).
15. Suk, W.A. and Wilson, S.H. Overview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health. In S.H. Wilson, W.A. Suk (eds), Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press, pp 3-15 (May 2002).
16. Groopman, J.D., Jackson, P.E., Turner, P., Wild, C.P., and Kensler, T.W. Validation of exposure and risk biomarkers: Aflatoxin as a case study. In S.H. Wilson, W.A. Suk (eds), Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press, pp 307-318 (May 2002).
17. Fennell, T.R., Miller, F.J., and Greenlee, W.F. Molecular biomarkers targeting signal transduction systems: The AH receptor pathway. In S.H. Wilson,W.A. Suk (eds), Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press, pp 355-364 (May 2002).
18. Perera, F.P. and Weinstein, I.B. Molecular epidemiology and carcinogen-DNA-adduct detection: Approaches to studies of human cancer causation. J. Chron. Dis. 35, 581-560 (1982).
19. National Research Council, Risk Assessment in the Federal Government: Managing the Process. National Academy Press, Washington, D.C. (1983).
20. Lioy, P.J. The analysis of total human exposure for exposure assessment: A multi-discipline science for examining human contact with contaminants. Environ. Sci. Technol. 24, 938-945 (1990).
21. Lioy, P.J. Human exposure assessment: A graduate level course. J. Expo. Anal. Environ. Epidemiol. 1, 271-281 (1991).
22. Weis, B.K., Balshaw, D. Potter, J.R. et al. Personalized exposure assessment: Promising approaches for human environmental health research. Environ. Hlth. Perspect. (in press).
23. Waters, M.D., and Fostel, J.M. Toxicogenomics and systems toxicology: Aims and prospects. Nat. Rev. Genet. 5, 936-948 (2004).
24. Georgopoulos, G., Wang, S.W., Vyas, V.M., Sun, Q., Burke, J., Vedantham, R., McCurdy, T., and Ozkaynak, H. A source-to-dose assessment of population exposures to find PM and ozone in Philadelphia, PA, during a summer 1999 episode. J. Expo. Anal. Environ. Epidemiol. (in press).
25. Hardy, J., and Langston, J.W. How many pathways are there to nigral death? Ann. Neurol. 56, 316-318 (2004).
26. Bolin, L.M., Strycharska-Orczyk, I., Murray, R., Langston, J.W., and DiMonte, D. Increased vulnerability of dopaminergic neurons in MPTPlesioned interleukin-6 deficient mice. J. Neurochem. 83, 167-175 (2002).
27. Betarbet, R. and Greenamyre, J.T. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Exp. Neurol. 189, 393-403 (2004).
28. Greenamyre, J.T. and Hastings, T.G. Parkinson's - divergent causes, convergent mechanisms. Science 304, 1120-1122 (2004).
29. Sherer, T.B., Betarbet, R., Testa, C.M. et al. Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23, 10756-10764 (2003).
30. Betarbet, R., Sherer, T.B., DiMonte, D.A., and Greenamyre, J.T. Mechanistic approaches to Parkinson's disease pathogenesis. Brain Pathol. 12, 499-510 (2002).
31. Betarbet, R., Sherer, T.B., and Greenamyre, J.T. Animal models of Parkinson's disease. Bioessays 24, 308-318 (2002).
32. Goldberg, M.S., Fleming, S.M., Palacino, J.J. et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278, 43628-43635 (2003).
33. Farrer, M., Kachergus, J., Forno, L. et al. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann. Neurol. 55, 174-179 (2004).
34. Tan, L.C., Tanner, C.M., Chen, R., Chan, P., Farrer, M., Hardy, J., and Langston, J.W. Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation. Mov. Disord. 18, 758-763 (2003).
35. Chen, R., Gosavi, N.S., Langston, J.W., and Chan, P. Parkin mutations are rare in patients with young-onset parkinsonism in a US population. Parkinsonism Relat. Disord. 9, 309-312, 2003.
36. Sherer, T.B., Betarbet, R., and Greenamyre, J.T. Environment, mitochondria, and Parkinson's disease. Neuroscientist 8, 192-197 (2002).
37. Sherer, T.B., Betarbet, R., Stout, A.K., Lund, S., Baptista, M., Panov, A.V., Cookson, M.R., and Greenamyre, J.T. An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alphasynuclein metabolism and oxidative damage. J. Neurosci. 22, 7006-7015 (2002).
38. Collins, F. The case for a US prospective cohort study of genes and environment. Nature 9, 475-477 (2004).
39. Potter, J.D. Toward the last cohort. Cancer Epidemiol. Biomarkers Prev. 13, 895-897 (2004).