Functional significance of adenosine receptors in the eye and their dysregulation in pseudoexfoliation syndrome;Funktionelle Bedeutung der Adenosinrezeptoren im Auge und ihre Dysregulation beim Pseudoexfoliationssyndrom

Ophthalmologe

Volumn 102, Issue 11, 2005, Pages 1074-1082

  Schlotzer Schrehardt U ^a,b   Zenkel, M ^a   Hofmann Rummelt, C ^a   Kruse, F E ^a   Naumann, G O ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

A3 adenosine receptor; Adenosine receptors; Ciliary epithelium; Pseudoexfoliation glaucoma; Pseudoexfoliation syndrome

Indexed keywords

ADENOSINE RECEPTOR;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EYE; GLAUCOMA; HUMAN; HYPOXIA; INTRAOCULAR PRESSURE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PSEUDOEXFOLIATION; RECEPTOR BINDING;

AGED; EPITHELIUM, CORNEAL; EXFOLIATION SYNDROME; FEMALE; GENE EXPRESSION REGULATION; GLAUCOMA; HUMANS; MALE; RECEPTORS, PURINERGIC P1; TISSUE DISTRIBUTION;

EID: 27744560964     PISSN: 0941293X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00347-005-1216-4     Document Type: Article

References (31)

1. 3-subtype adenosine receptors modulate intraocular pressure in the mouse. Br J Pharmacol 134: 241-245
2. 3 adenosine receptors reduces mouse intraocular pressure. Invest Ophthalmol Vis Sci 43: 3021-3026
3. Braunagel SC, Xiao JG, Chiou GC (1988) The potential role of adenosine in regulating blood flow in the eye. J Ocular Pharm 4: 61-73
4. Bruns RF (1990) Adenosine receptors: roles and pharmacology. Ann NY Acad Sci 603: 211-225
5. - channels of nonpigmented ciliary epithelial cells. Am J Physiol 273: C1354-C1361
6. Civan MM (2003) The fall and rise of active chloride transport: implications for regulation of intraocular pressure. J Exp Zool 300A: 5-13
7. Crosson CE (1995) Adenosine receptor activation modulates intraocular pressure in rabbits. J Pharmacol Exp Ther 273: 320-326
8. Crosson CE, Gray T (1996) Characterization of ocular hypertension induced by adenosine agonists. Invest Ophthalmol Vis Sci 37: 1833-1839
9. Daines BS, Kent AR, McAleer MS, Crosson CE (2003) Intraocular adenosine levels in normal and ocular hypertensive patients. J Ocular Pharmacol Ther 19: 113-119
10. Fleischhauer JC, Mitchell CH, Stamer WD, Karl MO, Peterson-Yantorno K, Civan MM (2003) Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. J Membr Biol 193: 121-136
11. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K-N, Linden J (2001) Nomenclature and classification of adenosine receptors. Pharm Rev 53: 527-552
12. Gregory CY, Abrams TA, Hall MO (1994) Stimulation of A2 adenosine receptors inhibits the ingestion of photoreceptor outer segments by retinal pigment epithelium. Invest Ophthalmol Vis Sci 35: 819-825
13. Helbig H, Schlötzer-Schrehardt U, Noske W, Kellner U, Foerster MH, Naumann GO (1994) Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome. German J Ophthalmol 3: 148-153
14. Johnson DH, Brubaker RF (1982) Dynamics of aqueous humor in the syndrome of exfoliation with glaucoma. Am J Ophthalmol 93: 629-634
15. 2A and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol 87: 353-356
16. Kvanta A, Seregard S, Sejersen S, Kull B, Fredholm BB (1997) Localization of adenosine receptor messenger RNAs in the rat eye. Exp Eye Res 65: 595-602
17. Larsen AK, Osbourne NN (1996) Involvement of adenosine in retinal ischemia. Studies on rat. Invest Ophthalmol Vis Sci 37: 2603-2611
18. Lutty GA, McLeod DS (2003) Retinal vascular development and oxygen-induced retinopathy: a role for adenosine. Progr Ret Eye Res 22: 95-111
19. Macaluso C, Frishman LJ, Frueh B, Kaelin-Lang A, Onoe S, Niemeyer G (2003) Multiple effects of adenosine in the arterially perfused mammalian eye. Possible mechanisms for the neuroprotective function of adenosine in the retina. Doc Ophthalmol 106: 51-59
20. - channels of nonpigmented ciliary epithelial cells. Am J Physiol 276: C659-C666
21. Naumann GO, Schlötzer-Schrehardt U, Küchle M (1998) Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology 105: 951-968
22. Okamura T, Kurogi Y, Hashimoto K, Sato S, Nishikawa H, Kiryu K, Nagao Y (2004) Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma. Bioorg Med Chem Lett 14: 3775-3779
23. Polska E, Ehrlich P, Luksch AQ, Fuchsjäger-Mayrl G, Schmetterer L (2003) Effects of adenosine on intraocular pressure, optic nerve head blood flow, and choroidal blood flow in healthy humans. Invest Ophthalmol Vis Sci 44: 3110-3114
24. Portellos M, Riva CE, Cranstoun SD, Petrig BL, Brucker AJ (1995) Effects of adenosine on ocular blood flow. Invest Ophthalmol Vis Sci 36: 1904-1909
25. Ramkumar V, Hallam DM, Nie Z (2001) Adenosine, oxidative stress and cytoprotection. Jpn J Pharmacol 86: 265-274
26. Riley MV, Winkler BS, Starnes CA, Peters MI (1996) Adenosine promotes regulation of corneal hydration through cyclic adenosine monophosphate. Invest Ophthalmol Vis Sci 37: 1-10
27. Roth S, Rosenbaum PS, Osinski J, Park SS, Toledano AY, Li B, Moshfeghi AA (1997) Ischemia induces significant changes in purine nucleoside concentration in the retina-choroid in rats. Exp Eye Res 65: 771-779
28. Schlötzer-Schrehardt U, Zenkel M, Hofmann-Rummelt C, Naumann GO (2004) The A3 adenosine receptor is upregulated in eyes with pseudoexfoliation syndrome and glaucoma. Invest Ophthalmol Vis Sci 45: E-Abstract 3535
29. Sen HA, Campochiaro PA (1989) Intravitreous injection of adenosine or its agonists causes breakdown of the blood-retinal barrier. Arch Ophthalmol 107: 1364-1367
30. Tian B, Gabelt BT, Crosson CE, Kaufman PL (1997) Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys. Exp Eye Res 64: 979-989
31. Wax M, Sanghavi DM, Lee CH, Kapadia M (1993) Purinergic receptors in ocular ciliary epithelial cells. Exp Eye Res 57: 89-95