In vitro inhibitory effect of quinolinic acid on aldehyde oxidase activity of guinea pig liver: A proposed mechanism

Saudi Pharmaceutical Journal

Volumn 13, Issue 4, 2005, Pages 164-170

  Al Omar, Mohamed A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aldehyde oxidase; Hydrogen peroxide; Quinolinic acid; Reactive oxygen species; Superoxide anion

Indexed keywords

ALDEHYDE OXIDASE; ALLOPURINOL; CHLORPROMAZINE; HETEROCYCLIC COMPOUND; HYDROGEN PEROXIDE; INDOLE 3 ALDHEHYDE; INDOLE DERIVATIVE; MENADIONE; PHTHALAZINE DERIVATIVE; QUINOLINIC ACID; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; FLUOROMETRY; GUINEA PIG; IN VITRO STUDY; LIVER; LIVER INJURY; NONHUMAN; OXIDATION; REACTION ANALYSIS; SPECTROPHOTOMETRY;

EID: 27744553894     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Schwarcz R. The kynurenine pathway of tryptophan degradation as a drug target. Curr Opin Pharmacol 2004;4:12-17.
2. Moroni, F. Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites. Eur J Pharmacol 1999;375:87-100.
3. Clarke SE, Harrell AW, Chenery RJ. Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver. Drug Metab Dispos 1995;23:251-254.
4. Beedham C. 2002. Enzyme Systems that Metabolise Drugs and other Xenobiotics: Molybdenum Hydroxylases, Ioannides, C., Ed., John Wiley & Sons Ltd, London, UK, pp:147-187.
5. Al-Omar MA, El-Subbagh HI, Beedham C. Smith JA. Role of molybdenum hydroxylases in diseases. Saudi Pharm J 2005;13:1-13.
6. Al-Omar MA, Beedham C, Al-Sarra I. Pathological roles of reactive oxygen species and their defence mechanisms. Saudi Pharm J 2004;12:1-18.
7. Chandrasekaran V, Zhai Y, Wagner M, Kaplan PL, Napoli JL, Higgins D. Retinoic acid regulates the morphological development of sympathetic neurons. J Neurobiol 2000;42:383-393.
8. Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 1998; 279:863-867.
9. Maynard TM, Sikich L, Lieberman JA, LaMantia A-S. Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia. Schizophrenia Bull 2001;27:457-476.
10. Mira L, Maia L, Barreira L, Manso CF. Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Arch Biochem Biophys 1995;318:53-58.
11. Turner NA, Doyle WA, Ventom AM, Bray RC. Properties of rabbit liver aldehyde oxidase and the relationship of the enzyme to xanthine oxidase and dehydrogenase. Eur J Biochem 1995;232:222-236.
12. Beedham C, Critchley DJP, Rance DJ. Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon. Arch Biochem Biophys 1995;319:481-490.
13. Rashidi MR. In vitro oxidation of purines by hepatic molybdenum hydroxylases. PhD Thesis, 1996, University of Bradford, UK.
14. Johnson C, Stubley-Beedham C, Stell JGP. Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite. Biochem Pharmacol 1984;33:3699-3705.
15. Al-Omar M, Beedham C, Belal F, Smith J, El-Emam A. Fluorimetric measurement of hydrogen peroxide produced during aldehyde oxidase catalysed oxidation using Scopoletin. J Med Sci 2005;5:10-20.
16. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
17. Johns DJ. Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates. J Clin Invest 1967;255:2694-2699.
18. Moriwaki, Y., Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K. In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol 1993;46:975-981.
19. MacDonald MJ, Grewe BK. Inhibition of phosphoenolpyruvate carboxykinase, glyceroneogenesis and fatty acid synthesis in rat adipose tissue by quinolinate and 3-mercaptopicolinate. Biochem Biophys Acta 1981;663:302-313.
20. Yoshihara S, Tatsumi K. Kinetic and inhibition studies on reduction of diphenylsulphoxide by guinea pig liver aldehyde oxidase. Arch Biochem Biophys 1986;249:8-14.
21. Rajagopalan KV, Fridovich I, Handler P. Hepatic aldehyde oxidase: I. purification and properties. J Biol Chem 1962;237:922-28.
22. Somjen GG. Nervenkitt: notes on the history of the concept of Neuroglia. Glia 1988;1:2-9.
23. Travis J. Glia: the brain's other cells. Science, 1994;266:970-972.
24. Berger R. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Somatic. Cell Mol Genet 1995;21:121-131.
25. Bendotti C, Prosperini E, Kurosaki M, Garattini E, Terao M. Selective Localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons. Neuro Report 1997;8:2343-2349.
26. Beagles KE, Morrison PF, Heyes MP. Quinolinic acid: in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis. J Neurochem 1998;70:281-291.
27. Behan WM, McDonald M, Darlington LG, Stone TW. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl. Br J Pharmacol 1999;128:1754-1760.
28. Belle NA, Dalmolin GD, Fonini G, Rubin MA, Rocha JB. Polyamine reduces lipid peroxidation induced by different prooxidant agents. Brain Res 2004;1008:245-251.
29. Banoo R. Aminoquinolines as substrates for liver cytosol enzymes. PhD Thesis, 1980, University of Bradford, UK.
30. Johnson C, Beedham CS, Stell JGP. Hydralazine: a potent inhibitor of aldehyde oxidase activity in vitro and in vivo. Biochem Pharmacol 1985;34:4251-4256.