Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

In Vivo

Volumn 19, Issue 6, 2005, Pages 959-964

  Tsujita Kyutoku, Miki ^a   Uehara, Norihisa ^a   Matsuoka, Yoichiro ^a   Kyutoku, Shigeo ^b   Ogawa, Yutaka ^a   Tsubura, Airo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KISHIWADA CITY HOSPITAL   (Japan)

Author keywords

Fibroblasts; Keloid; Smad; TGF

Indexed keywords

SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADOLESCENT; ADULT; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DERMIS; FEMALE; HUMAN; HUMAN TISSUE; KELOID; MALE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN DEFECT; SKIN FIBROBLAST;

EID: 27744552121     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Niessen FB, Spauwen PH, Schalkwijk J and Kon M: On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104: 1435-1458, 1999.
2. Tuan TL and Nichter LS: The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 4: 19-24, 1998.
3. Bettinger DA, Yager DR, Diegelmann RF and Cohen IK: The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis. Plast Reconstr Surg 98: 827-833, 1996.
4. Chin GS, Liu W, Peled Z, Lee TY, Steinbrech DS, Hsu M and Longaker MT: Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts. Plast Reconstr Surg 108: 423-429, 2001.
5. Leask and Abraham DJ: TGF-beta signaling and the fibrotic response. FASEB J 18: 816-827, 2004.
6. Phan TT, Lim IJ, Chan SY,Tan, EK Lee ST and Longaker MT: Suppression of transforming growth factor beta/Smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma 57: 1032-1037, 2004.
7. Tsujita-Kyutoku M, Yuri T, Danbara N, Senzaki H, Kiyozuka Y, Uehara N, Takada H, Hada T, Miyazawa T, Ogawa Y and Tsubura A: Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo: potential mechanisms of action. Breast Cancer Res 6: R291-R299, 2004.
8. Luo S, Benathan M, Raffoul W, Panizzon RG and Egloff DV: Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg 107: 87-96, 2001.
9. Nakaoka H, Miyauchi S and Miki Y: Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. Acta Derm Venereol 75: 102-104, 1995.
10. Giugliano G, Pasquali D, Notaro A, Brongo S, Nicoletti G, D'Andrea F, Bellastella A and Sinisi AA: Verapamil inhibits interleukin-6 and vascular endothelial growth factor production in primary cultures of keloid fibroblasts. Br J Plast Surg 56: 804-809, 2003.
11. Bayat A, Bock O, Mrowietz U, Ollier WE and Ferguson MW: Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels. Plast Reconstr Surg 111: 535-543, 2003.
12. Xia W, Phan TT, Lim IJ, Longaker MT and Yang GP: Complex epithelial-mesenchymal interactions modulate transforming growth factor-beta expression in keloid-derived cells. Wound Repair Regen 12: 546-556, 2004.
13. Lee TY, Chin GS, Kim WJ, Chau D, Gittes GK and Longaker MT: Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids. Ann Plast Surg 43: 179-184, 1999.
14. Chodon T, Sugihara T, Igawa HH, Funayama E and Furukawa H: Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance. Am J Pathol 157: 1661-1669, 2000.
15. Massague J: TGFbeta signaling: receptors, transducers, and Mad proteins. Cell 85: 947-950, 1996.
16. Massague J: TGF-beta signal transduction. Annu Rev Biochem 67: 753-791, 1998.
17. Massague J and Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
18. Wendling J, Marchand A, Mauviel A and Verrecchia F: 5-Fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation. Mol Pharmacol 64: 707-713, 2003.