Small artery endothelial dysfunction in postmenopausal women: In vitro function, morphology, and modification by estrogen and selective estrogen receptor modulators

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 11, 2005, Pages 6113-6122

  Kublickiene, Karolina ^a,c   Svedas, Eimantas ^a   Landgren, Britt Marie ^a   Crisby, Milita ^a   Nahar, Nasrin ^a   Nisell, Henry ^a   Poston, Lucilla ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA AGONIST; FULVESTRANT; GENISTEIN; HORMONE RECEPTOR STIMULATING AGENT; PHYTOESTROGEN; PYRAZOLE DERIVATIVE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ADULT; ARTERY ENDOTHELIUM; ARTERY WALL; ARTICLE; BIOPSY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INCUBATION TIME; INTESTINE PRESSURE; MORPHOLOGY; MYOGRAPHY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; VASCULAR ENDOTHELIUM;

EID: 27744543380     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0419     Document Type: Article

References (62)

1. Alexander RW, Dzau VJ 2000 Vascular biology: the past 50 years. Circulation 102:112-116
2. Sorensen KE, Dorup I, Hermann AP, Mosekilde L 1998 Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function. Circulation 97:1234-1238
3. Kelm M 2002 Flow-mediated dilatation in human circulation: diagnostic and therapeutic aspects. Am J Physiol Heart Circ Physiol 282:H1-H5
4. Taddei S, Virdis A, Ghiadoni L, Mattei P, Sudano I, Bernini G, Pinto S, Salvetti A 1996 Menopause is associated with endothelial dysfunction in women. Hypertension 28:576-582
5. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH 1987 Menopause and the risk of coronary heart disease in women. N Engl J Med 316:1105-1110
6. Gilligan DM, Badar DM, Panza JA, Quyyumi AA, Cannon 3rd RO 1994 Acute vascular effects of estrogen in postmenopausal women. Circulation 90:786-791
7. Bush DE, Jones CE, Bass KM, Walters GK, Bruza JM, Ouyang P 1998 Estrogen replacement reverses endothelial dysfunction in postmenopausal women. Am J Med 104:552-558
8. Lieberman EH, Gerhard MD, Uehata A, Walsh BW, Selwyn AP, Ganz P, Yeung AC, Creager MA 1994 Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 121:936-941
9. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280:605-613
10. Rossouw JE AG, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333
11. Bian Z, Nilsson S, Gustafsson JA 2001 Selective estrogen receptor modulators and coronary heart disease. Trends Cardiovasc Med 11:196-202
12. Mulvany M 1990 Structure and function of small arteries in hypertension. J Hypertens Suppl 8:S225-S232
13. Svedas E, Nisell H, VanWijk M, Nikas Y, Kublickiene K 2002 Endothelial dysfunction in uterine circulation in preeclampsia: can estrogens improve it? Am J Obstet Gynecol 187:1608-1616
14. Hashimoto M KK, Eto M, Akishita M, Ako J, Iijima K, Kim S, Toba K, Yoshizumi M, Ouchi Y 2000 Association of coronary risk factors and endothelium-dependent flow-mediated dilatation of the brachial artery. Hypertens Res 23:233-238
15. Lauer T, Kleinbongard P, Preik M, Rauch BH, Deussen A, Feelisch M, Strauer BE, Kelm M 2003 Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature. Basic Res Cardiol 98:84-89
16. Sarabi M, Millgard J, Lind L 1999 Effects of age, gender and metabolic factors on endothelium-dependent vasodilation: a population-based study. J Intern Med 246:265-274
17. Cockell AP, Poston L 1997 Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia. Hypertension 30:247-251
18. Napoli C, Ignarro LJ 2001 Nitric oxide and atherosclerosis. Nitric Oxide 5:88-97
19. Bungum L, Kvernebo K, Oian P, Maltau JM 1996 Laser Doppler-recorded reactive hyperaemia in the forearm skin during the menstrual cycle. Br J Obstet Gynaecol 103:70-75
20. Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, Sagara Y, Taketani Y, Orimo H, Ouchi Y 1995 Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex. Circulation 92:3431-3435
21. Bowyer L, Brown M, Jones M 2001 Vascular reactivity in men and women of reproductive age. Am J Obstet Gynecol 185:88-96
22. Majmudar NG, Robson SC, Ford GA 2000 Effects of the menopause, gender, and estrogen replacement therapy on vascular nitric oxide activity. J Clin Endocrinol Metab 85:1577-1583
23. Gerhard M, Roddy MA, Creager SJ, Creager MA 1996 Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27:849-853
24. Jensen-Urstad K, Johansson J 2001 Gender difference in age-related changes in vascular function. J Intern Med 250:29-36
25. Huang A, Sun D, Koller A, Kaley G 1998 Gender difference in flow-induced dilation and regulation of shear stress: role of estrogen and nitric oxide. Am J Physiol Regul Integr Comp Physiol 275:R1571-R1577
26. Kublickiene K, Cockell A, Nisell H, Poston L 1997 Role of nitric oxide in the regulation of vascular tone in pressurized and perfused resistance myometrial arteries from term pregnant women. Am J Obstet Gynecol 177:1263-1269
27. Mombouli JV, Vanhoutte PM 1999 Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol 31:61-74
28. Du X-J, Riemersma RA, Dart AM 1995 Cardiovascular protection by oestrogen is partly mediated through modulation of autonomic nervous function. Cardiovasc Res 30:161-165
29. Goligorsky MS, Li H, Brodsky S, Chen J 2002 Relationships between caveolae and eNOS: everything in proximity and the proximity of everything. Am J Physiol Renal Physiol 283:F1-F10
30. Luksha L, Kublickiene, K 2005 Implications for endothelium-derived hyperpolarizing factor (EDHF) in women's cardiovascular health. Curr Women's Health Rev 1:67-78
31. Razandi M, Pedram A, Levin ER 2000 Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem 275:38540-38546
32. Sudoh N, Toba K, Akishita M, Ako J, Hashimoto M, Iijima K, Kim S, Liang YQ, Ohike Y, Watanabe T, Yamazaki I, Yoshizumi M, Eto M, Ouchi Y 2001 Estrogen prevents oxidative stress-induced endothelial cell apoptosis in rats. Circulation 103:724-729
33. Kawano H, Motoyama T, Kugiyama K, Hirashima O, Ohgushi M, Fujii H, Ogawa H, Yasue H 1997 Gender difference in improvement of endothelium-dependent vasodilation after estrogen supplementation. J Am Coll Cardiol 30:914-919
34. Cockell A, Poston L 1997 17β-Estradiol stimulates flow-induced vasodilatation in isolated small mesenteric arteries from prepubertal female rats. Am J Obstet Gynecol 177:1432-1436
35. Magness RR, Sullivan JA, Li Y, Phernetton TM, Bird IM 2001 Endothelial vasodilator production by uterine and systemic arteries. VI. Ovarian and pregnancy effects on eNOS and NOx. Am J Physiol Heart Circ Physiol 280:H1692-H1698
36. Mendelsohn ME 2002 Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol 90:F3-F4
37. Wagner AH, Schroeter M, Hecker M 2001 17β-Estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J 15:2121-2130
38. Chambliss KL, Shaul PW 2002 Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae. Steroids 67:413-419
39. Ihionkhan CE, Chambliss KL, Gibson LL, Hahner LD, Mendelsohn ME, Shaul PW 2002 Estrogen causes dynamic alterations in endothelial estrogen receptor expression. Circ Res 91:814-820
40. Harris HA, Katzenellenbogen JA, Katzenellenbogen BS 2002 Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 143:4172-4177
41. Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, Arnal JF 2001 Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-α but not estrogen receptor-β. Circulation 103:423-428
42. Darblade B, Pendaries C, Krust A, Dupont S, Fouque MJ, Rami J, Chambon P, Bayard F, Arnal JF 2002 Estradiol alters nitric oxide production in the mouse aorta through the α-, but not β-, estrogen receptor. Circ Res 90:413-419
43. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME 2002 Estrogen receptor-α mediates the protective effects of estrogen against vascular injury. Circ Res 90:1087-1092
44. Mosca L 2001 Rationale and overview of the Raloxifene Use for the Heart (RUTH) Trial. Ann NY Acad Sci 949:181-185
45. Goodman-Gruen D, Kritz-Silverstein D 2001 Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 131:1202-1206
46. Altavilla D, Crisafulli A, Marini H, Esposito M, D'Anna R, Corrado F, Bitto A, Squadrito F 2004 Cardiovascular effects of the phytoestrogen genistein. Curr Med Chem Cardiovasc Hematol Agents 2:179-186
47. Rahimian R, Dube GP, Toma W, Dos Santos N, McManus BM, van Breemen C 2002 Raloxifene enhances nitric oxide release in rat aorta via increasing endothelial nitric oxide mRNA expression. Eur J Pharmacol 434:141-149
48. Squadrito F, Altavilla D, Squadrito G, Saitta A, Cucinotta D, Minutoli L, Deodato B, Ferlito M, Campo GM, Bova A, Caputi AP 2000 Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 45:454-462
49. Pavo I, Laszlo F, Morschl E, Nemcsik J, Berko A, Cox DA, Laszlo FA 2000 Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats. Eur J Pharmacol 410:101-104
50. Alexandersen P, Haarbo J, Breinholt V, Christiansen C 2001 Dietary phytoestrogens and estrogen inhibit experimental atherosclerosis. Climacteric 4:151-159
51. Karamsetty MR, Pietras L, Klinger JR, Lanzillo JJ, Leiter JC, Ou LC, Hill NS 2001 The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats. Respir Physiol 128:219-227
52. Savolainen-Peltonen H, Luoto NM, Kangas L, Hayry P 2004 Selective estrogen receptor modulators prevent neointima formation after vascular injury. Mol Cell Endocrinol 227:9-20
53. Colacurci N, Manzella D, Fornaro F, Carbonella M, Paolisso G 2003 Endothelial function and menopause: effects of raloxifene administration. J Clin Endocrinol Metab 88:2135-2140
54. Squadrito F, Altavilla D, Crisafulli A, Saitta A, Cucinotta D, Morabito N, D'Anna R, Corrado F, Ruggeri P, Frisina N, Squadrito G 2003 Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. Am J Med 114:470-476
55. Saitta A, Altavilla D, Cucinotta D, Morabito N, Frisina N, Corrado F, D'Anna R, Lasco A, Squadrito G, Gaudio A, Cancellieri F, Arcoraci V, Squadrito F 2001 Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma NO concentrations, endothelin-1 levels, and endothelium-dependent vasodilation in postmenopausal women. Arterioscler Thromb Vasc Biol 21:1512-1519
56. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S, McGrath BP 2001 Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 86:3053-3060
57. Hale G, Paul-Labrador M, Dwyer JH, Merz CNB 2002 Isoflavone supplementation and endothelial function in menopausal women. Clin Endocrinol (Oxf) 56:693-701
58. Duschek EJJ, Stehouwer CDA, De Valk-De Roo GW, Schalkwijk CG, Lambert J, Netelenbos C 2003 Raloxifene, conjugated oestrogen and endothelial function in postmenopausal women. J Intern Med 254:85-94
59. Makela S, Savolainen H, Aavik E, Myllarniemi M, Strauss L, Taskinen E, Gustafsson JA, Hayry P 1999 Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors α and β. Proc Natl Acad Sci USA 96:7077-7082
60. Vogelvang TE, van der Mooren MJ, Mijatovic V 2004 Hormone replacement therapy, selective estrogen receptor modulators, and tissue-specific compounds: cardiovascular effects and clinical implications. Treat Endocrinol 3:105-115
61. Karas RH, Hodgin JB, Kwoun M, Krege JH, Aronovitz M, Mackey W, Gustafsson JA, Korach KS, Smithies O, Mendelsohn ME 1999 Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice. Proc Natl Acad Sci USA 96:15133-15136
62. Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thoren P, Smithies O, Gustafsson JA, Mendelsohn ME 2002 Abnormal vascular function and hypertension in mice deficient in estrogen receptor β. Science 295:505-508