메뉴 건너뛰기




Volumn 4, Issue 11, 2005, Pages 1675-1682

Constitutively active Cdc42 mutant confers growth disadvantage in cell transformation

Author keywords

Cdc42; GTPase; JNK; Oncogenes; Transformation

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; RAF PROTEIN; RAS PROTEIN;

EID: 27744541729     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.11.2170     Document Type: Article
Times cited : (24)

References (44)
  • 1
    • 1442274703 scopus 로고    scopus 로고
    • Cdc42: New roads to travel
    • Cerione RA. Cdc42: New roads to travel. Trends Cell Biol 2004; 14:127-32.
    • (2004) Trends Cell Biol , vol.14 , pp. 127-132
    • Cerione, R.A.1
  • 2
    • 0035313804 scopus 로고    scopus 로고
    • Multiple roles for Cdc42 in cell regulation
    • Erickson JW, Cerione RA. Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol 2001; 13:153-7.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 153-157
    • Erickson, J.W.1    Cerione, R.A.2
  • 3
    • 2342432240 scopus 로고    scopus 로고
    • Cdc42 - The centre of polarity
    • Etienne-Manneville S. Cdc42 - the centre of polarity. J Cell Sci 2004; 117:1291-300.
    • (2004) J Cell Sci , vol.117 , pp. 1291-1300
    • Etienne-Manneville, S.1
  • 4
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 1993; 366:643-54.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 6
    • 0035668525 scopus 로고    scopus 로고
    • Dbl family guanine nucleotide exchange factors
    • Zheng Y. Dbl family guanine nucleotide exchange factors. Trends Biochem Sci 2001; 26:724-32.
    • (2001) Trends Biochem Sci , vol.26 , pp. 724-732
    • Zheng, Y.1
  • 7
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 2000; 348:241-55.
    • (2000) Biochem J , vol.348 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 8
    • 0036181428 scopus 로고    scopus 로고
    • The evolutionary history of effectors downstream of Cdc42 and Rac
    • REVIEWS0002
    • Cotteret S, Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol 2002; 3:(REVIEWS0002).
    • (2002) Genome Biol , vol.3
    • Cotteret, S.1    Chernoff, J.2
  • 9
    • 0007051410 scopus 로고
    • Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21
    • USA
    • Sigal IS, Gibbs JB, D'Alonzo JS, Scolnick EM. Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21. Proc Natl Acad Sci USA 1986; 83:4725-9.
    • (1986) Proc Natl Acad Sci , vol.83 , pp. 4725-4729
    • Sigal, I.S.1    Gibbs, J.B.2    D'Alonzo, J.S.3    Scolnick, E.M.4
  • 11
    • 0030992814 scopus 로고    scopus 로고
    • Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
    • Qiu RG, Abo A, McCormick F, Symons M. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol Cell Biol 1997; 17:3449-58.
    • (1997) Mol Cell Biol , vol.17 , pp. 3449-3458
    • Qiu, R.G.1    Abo, A.2    McCormick, F.3    Symons, M.4
  • 13
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 1995; 15:6443-53.
    • (1995) Mol Cell Biol , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 14
    • 0026002058 scopus 로고
    • p21 with a phenylalanine 28 - leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties
    • Reinstein J, Schlichting I, Frech M, Goody RS, Wittinghofer A. p21 with a phenylalanine 28 - leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties. J Biol Chem 1991; 266:17700-6.
    • (1991) J Biol Chem , vol.266 , pp. 17700-17706
    • Reinstein, J.1    Schlichting, I.2    Frech, M.3    Goody, R.S.4    Wittinghofer, A.5
  • 15
    • 0031260578 scopus 로고    scopus 로고
    • A novel Cdc42Hs mutant induces cellular transformation
    • Lin R, Bagrodia S, Cerione R, Manor D. A novel Cdc42Hs mutant induces cellular transformation. Curr Biol 1997; 7:794-7.
    • (1997) Curr Biol , vol.7 , pp. 794-797
    • Lin, R.1    Bagrodia, S.2    Cerione, R.3    Manor, D.4
  • 16
    • 0033551698 scopus 로고    scopus 로고
    • Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation
    • Lin R, Cerione RA, Manor D. Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol Chem 1999; 274:23633-41.
    • (1999) J Biol Chem , vol.274 , pp. 23633-23641
    • Lin, R.1    Cerione, R.A.2    Manor, D.3
  • 17
    • 4444341881 scopus 로고    scopus 로고
    • Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    • Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 2004; 15:713-725.
    • (2004) Mol Cell , vol.15 , pp. 713-725
    • Sabapathy, K.1    Hochedlinger, K.2    Nam, S.Y.3    Bauer, A.4    Karin, M.5    Wagner, E.F.6
  • 18
    • 0024121513 scopus 로고
    • The predicted DBL oncogene product defines a distinct class of transforming proteins
    • USA
    • Eva A, Vecchio G, Rao CD, Tronick SR, Aaronson SA. The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc Natl Acad Sci USA 1988; 85:2061-5.
    • (1988) Proc Natl Acad Sci , vol.85 , pp. 2061-2065
    • Eva, A.1    Vecchio, G.2    Rao, C.D.3    Tronick, S.R.4    Aaronson, S.A.5
  • 20
    • 0027972531 scopus 로고
    • Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products
    • Toksoz D, Williams DA. Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene 1994; 9:621-8.
    • (1994) Oncogene , vol.9 , pp. 621-628
    • Toksoz, D.1    Williams, D.A.2
  • 21
    • 0022368305 scopus 로고
    • Specific growth response of ras-transformed embryo fibroblasts to tumour promoters
    • Dotto GP, Parada LF, Weinberg RA. Specific growth response of ras-transformed embryo fibroblasts to tumour promoters. Nature 1985; 318:472-5.
    • (1985) Nature , vol.318 , pp. 472-475
    • Dotto, G.P.1    Parada, L.F.2    Weinberg, R.A.3
  • 22
    • 0025320158 scopus 로고
    • EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling
    • Di Fiore PP, Segatto O, Taylor WG, Aaronson SA, Pierce JH. EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science 1990; 248:79-83.
    • (1990) Science , vol.248 , pp. 79-83
    • Di Fiore, P.P.1    Segatto, O.2    Taylor, W.G.3    Aaronson, S.A.4    Pierce, J.H.5
  • 23
    • 0026806540 scopus 로고
    • Five PDGF B amino acid substitutions convert PDGF a to a PDGF B-like transforming molecule
    • LaRochelle WJ, Pierce JH, May-Siroff M, Giese N, Aaronson SA. Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule. J Biol Chem 1992; 267:17074-7.
    • (1992) J Biol Chem , vol.267 , pp. 17074-17077
    • LaRochelle, W.J.1    Pierce, J.H.2    May-Siroff, M.3    Giese, N.4    Aaronson, S.A.5
  • 25
    • 0000153275 scopus 로고    scopus 로고
    • Transformation activity of Cdc42 requires a region unique to Rho-related proteins
    • Wu WJ, Lin R, Cerione RA, Manor D. Transformation activity of Cdc42 requires a region unique to Rho-related proteins. J Biol Chem 1998; 273:16655-8.
    • (1998) J Biol Chem , vol.273 , pp. 16655-16658
    • Wu, W.J.1    Lin, R.2    Cerione, R.A.3    Manor, D.4
  • 26
    • 0025758833 scopus 로고
    • A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr
    • Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, Graziani G, Tronick SR, Aaronson SA, Eva A. A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. New Biol 1991; 3:372-9.
    • (1991) New Biol , vol.3 , pp. 372-379
    • Ron, D.1    Zannini, M.2    Lewis, M.3    Wickner, R.B.4    Hunt, L.T.5    Graziani, G.6    Tronick, S.R.7    Aaronson, S.A.8    Eva, A.9
  • 27
    • 0027958423 scopus 로고
    • Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
    • Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evans T, Cerione RA, Zheng Y. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem 1994; 269:62-5.
    • (1994) J Biol Chem , vol.269 , pp. 62-65
    • Hart, M.J.1    Eva, A.2    Zangrilli, D.3    Aaronson, S.A.4    Evans, T.5    Cerione, R.A.6    Zheng, Y.7
  • 28
    • 0028967665 scopus 로고
    • Direct involvement of the small GTP-binding protein Rho in lbc oncogene function
    • Zheng Y, Olson MF, Hall A, Cerione RA, Toksoz D. Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J Biol Chem 1995; 270:9031-4.
    • (1995) J Biol Chem , vol.270 , pp. 9031-9034
    • Zheng, Y.1    Olson, M.F.2    Hall, A.3    Cerione, R.A.4    Toksoz, D.5
  • 29
    • 20744453511 scopus 로고    scopus 로고
    • Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L
    • Wang JB, Wu WJ, Cerione RA. Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L. J Biol Chem 2005; 280:22883-91.
    • (2005) J Biol Chem , vol.280 , pp. 22883-22891
    • Wang, J.B.1    Wu, W.J.2    Cerione, R.A.3
  • 30
    • 0141426629 scopus 로고    scopus 로고
    • Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation
    • Wu WJ, Tu S, Cerione RA. Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 2003; 114:715-25.
    • (2003) Cell , vol.114 , pp. 715-725
    • Wu, W.J.1    Tu, S.2    Cerione, R.A.3
  • 31
    • 0028820587 scopus 로고
    • Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
    • Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem 1995; 270:23934-6.
    • (1995) J Biol Chem , vol.270 , pp. 23934-23936
    • Zhang, S.1    Han, J.2    Sells, M.A.3    Chernoff, J.4    Knaus, U.G.5    Ulevitch, R.J.6    Bokoch, G.M.7
  • 32
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995; 81:1137-46.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 33
    • 0028875683 scopus 로고
    • Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
    • Bagrodia S, Derijard B, Davis RJ, Cerione RA. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J Biol Chem 1995; 270:27995-8.
    • (1995) J Biol Chem , vol.270 , pp. 27995-27998
    • Bagrodia, S.1    Derijard, B.2    Davis, R.J.3    Cerione, R.A.4
  • 34
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995; 81:1147-57.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 35
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994; 76:1025-37.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 36
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995; 267:389-93.
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Derijard, B.3    Davis, R.J.4
  • 37
    • 0028609209 scopus 로고
    • JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
    • Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R, Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 1994; 8:2996-3007.
    • (1994) Genes Dev , vol.8 , pp. 2996-3007
    • Kallunki, T.1    Su, B.2    Tsigelny, I.3    Sluss, H.K.4    Derijard, B.5    Moore, G.6    Davis, R.7    Karin, M.8
  • 38
    • 17144371848 scopus 로고    scopus 로고
    • JNK2: A negative regulator of cellular proliferation
    • Sabapathy K, Wagner EF. JNK2: A negative regulator of cellular proliferation. Cell Cycle 2004; 3:1520-3.
    • (2004) Cell Cycle , vol.3 , pp. 1520-1523
    • Sabapathy, K.1    Wagner, E.F.2
  • 41
    • 0032557526 scopus 로고    scopus 로고
    • Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases
    • Montaner S, Perona R, Saniger L, Lacal JC. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. J Biol Chem 1998; 273:12779-85.
    • (1998) J Biol Chem , vol.273 , pp. 12779-12785
    • Montaner, S.1    Perona, R.2    Saniger, L.3    Lacal, J.C.4
  • 42
    • 0032479167 scopus 로고    scopus 로고
    • Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun
    • Westwick JK, Lee RJ, Lambert QT, Symons M, Pestell RG, Der CJ, Whitehead IP. Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J Biol Chem 1998; 273:16739-47.
    • (1998) J Biol Chem , vol.273 , pp. 16739-16747
    • Westwick, J.K.1    Lee, R.J.2    Lambert, Q.T.3    Symons, M.4    Pestell, R.G.5    Der, C.J.6    Whitehead, I.P.7
  • 43
    • 0031026132 scopus 로고    scopus 로고
    • Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
    • Westwick JK, Lambert QT, Clark GJ, Symons, Van Aelst L, Pestell RG, Der C.J. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol 1997; 17:1324-35.
    • (1997) Mol Cell Biol , vol.17 , pp. 1324-1335
    • Westwick, J.K.1    Lambert, Q.T.2    Clark, G.J.3    Symons4    Van Aelst, L.5    Pestell, R.G.6    Der, C.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.