Late administration of a lipophilic tyrosine kinase inhibitor prevents lipopolysaccharide and Escherichia coli-induced lethal toxicity

Journal of Infectious Diseases

Volumn 173, Issue 4, 1996, Pages 927-933

  Vanichkin, Alexey ^b   Patya, Miriam ^b   Gazit, Aviv ^b   Levitzki, Alexander ^b   Novogrodsky, Abraham ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 (2,2 DICYANOVINYL) 2 NITROPHENOL; BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1; N (4 BUTYLPHENYL) ALPHA CYANOCAFFEIC ACID AMIDE; TUMOR NECROSIS FACTOR ALPHA; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; GRAM NEGATIVE SEPSIS; LIPOPHILICITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0030053284     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.4.927     Document Type: Article

References (5)

1. Morrison DC, Ryan JL. Endotoxins and disease mechanism. Annu Rev Med 1987;38:417-32.
2. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328:1471-7.
3. Raetz CRH, Ulevitch RJ, Wright SD, Sibley CH, Ding A, Nathan CF. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1991;5:2652-60.
4. Michie HR, Spriggs DR, Manogue KR, et al. Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery 1988;104:280-7.
5. Beutler B, Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu Rev Biochem 1988;57:505-18.