메뉴 건너뛰기




Volumn 26, Issue 5, 2005, Pages 909-917

α1-antitrypsin deficiency and lung disease: Risk modification by occupational and environmental inhalants

Author keywords

1 antitrypsin; antitrypsin deficiency; Gene environment interaction; Occupational disorder; Occupational exposure; Passive smoking

Indexed keywords

ALPHA 1 ANTITRYPSIN; TOBACCO SMOKE;

EID: 27744508591     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.05.00021605     Document Type: Article
Times cited : (42)

References (60)
  • 1
    • 0031807729 scopus 로고    scopus 로고
    • Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
    • Silverman EK, Chapman HA, Drazen JM, et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med 1998; 157: 1770-1778.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 1770-1778
    • Silverman, E.K.1    Chapman, H.A.2    Drazen, J.M.3
  • 2
    • 0036130108 scopus 로고    scopus 로고
    • The role of genotype in determining the effects of cigarette smoking on pulmonary function
    • Tishler PV, Carey VJ, Reed T, Fabsitz RR. The role of genotype in determining the effects of cigarette smoking on pulmonary function. Genet Epidemiol 2002; 22: 272-282.
    • (2002) Genet. Epidemiol. , vol.22 , pp. 272-282
    • Tishler, P.V.1    Carey, V.J.2    Reed, T.3    Fabsitz, R.R.4
  • 3
    • 0018128288 scopus 로고
    • Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z
    • Larsson C. Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z. Acta Med Scand 1978; 204: 345-351.
    • (1978) Acta Med. Scand. , vol.204 , pp. 345-351
    • Larsson, C.1
  • 4
    • 0021960082 scopus 로고
    • Smoking, lung function, and alpha 1-antitrypsin deficiency
    • Janus ED, Phillips NT, Carrell RW. Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet 1985; 1: 152-154.
    • (1985) Lancet , vol.1 , pp. 152-154
    • Janus, E.D.1    Phillips, N.T.2    Carrell, R.W.3
  • 5
    • 0025350658 scopus 로고
    • Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy
    • Crystal RG. Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J Clin Invest 1990; 85: 1343-1352.
    • (1990) J. Clin. Invest. , vol.85 , pp. 1343-1352
    • Crystal, R.G.1
  • 6
    • 0033662117 scopus 로고    scopus 로고
    • Reference distributions for the positive acute phase serum proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: A practical, simple, and clinically relevant approach in a large cohort
    • Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY. Reference distributions for the positive acute phase serum proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: a practical, simple, and clinically relevant approach in a large cohort. J Clin Lab Anal 2000; 14: 284-292.
    • (2000) J. Clin. Lab. Anal. , vol.14 , pp. 284-292
    • Ritchie, R.F.1    Palomaki, G.E.2    Neveux, L.M.3    Navolotskaia, O.4    Ledue, T.B.5    Craig, W.Y.6
  • 7
    • 0034126045 scopus 로고    scopus 로고
    • Airways inflammation in chronic bronchitis: The effects of smoking and alpha1-antitrypsin deficiency
    • Hill AT, Bayley DL, Campbell EJ, Hill SL, Stockley RA. Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency. Eur Respir J 2000; 15: 886-890.
    • (2000) Eur. Respir. J. , vol.15 , pp. 886-890
    • Hill, A.T.1    Bayley, D.L.2    Campbell, E.J.3    Hill, S.L.4    Stockley, R.A.5
  • 8
    • 0022672684 scopus 로고
    • The biochemical pathogenesis of chronic obstructive pulmonary diseases: Protease-antiprotease imbalance in emphysema and diseases of the airways
    • Kuhn CIII. The biochemical pathogenesis of chronic obstructive pulmonary diseases: protease-antiprotease imbalance in emphysema and diseases of the airways. J Thorac Imaging 1986; 1: 1-6.
    • (1986) J. Thorac. Imaging , vol.1 , pp. 1-6
    • Kuhn, C.I.I.I.1
  • 10
    • 0035823595 scopus 로고    scopus 로고
    • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
    • Silverman GA, Bird PI, Carrell RW, et al. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001; 276: 33293-33296.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33293-33296
    • Silverman, G.A.1    Bird, P.I.2    Carrell, R.W.3
  • 11
    • 0036948098 scopus 로고    scopus 로고
    • SNPper: Retrieval and analysis of human SNPs
    • Riva A, Kohane IS. SNPper: retrieval and analysis of human SNPs. Bioinformatics 2002; 18: 1681-1685.
    • (2002) Bioinformatics , vol.18 , pp. 1681-1685
    • Riva, A.1    Kohane, I.S.2
  • 12
    • 0023898432 scopus 로고
    • Molecular basis of alpha-1-antitrypsin deficiency
    • Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 1988; 84: 13-31.
    • (1988) Am. J. Med. , vol.84 , pp. 13-31
    • Brantly, M.1    Nukiwa, T.2    Crystal, R.G.3
  • 13
    • 0028150714 scopus 로고
    • Identification and DNA sequence analysis of 15 new alpha 1-antitrypsin variants, including two PI*Q0 alleles and one deficient PI*M allele
    • Faber JP, Poller W, Weidinger S, et al. Identification and DNA sequence analysis of 15 new alpha 1-antitrypsin variants, including two PI*Q0 alleles and one deficient PI*M allele. Am J Hum Genet 1994; 55: 1113-1121.
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 1113-1121
    • Faber, J.P.1    Poller, W.2    Weidinger, S.3
  • 14
    • 0036433482 scopus 로고    scopus 로고
    • Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: Summary of an analysis of published genetic epidemiologic surveys
    • de Serres FJ. Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys. Chest 2002; 122: 1818-1829.
    • (2002) Chest , vol.122 , pp. 1818-1829
    • de Serres, F.J.1
  • 15
    • 0033859938 scopus 로고    scopus 로고
    • Molecular mechanisms of alpha1-antitrypsin null alleles
    • Lee JH, Brantly M. Molecular mechanisms of alpha1-antitrypsin null alleles. Respir Med 2000; 94: Suppl. C, S7-S11.
    • (2000) Respir. Med. , vol.94 , Issue.SUPPL. C
    • Lee, J.H.1    Brantly, M.2
  • 16
    • 0141706635 scopus 로고    scopus 로고
    • Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
    • American Thoracic Society/European Respiratory Society Statement
    • American Thoracic Society/European Respiratory Society Statement. Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency. Am J Respir Crit Care Med 2003; 168: 818-900.
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , pp. 818-900
  • 17
    • 0020678269 scopus 로고
    • Alpha 1 antitrypsin deficiency: The clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z. A survey by the British Thoracic Association
    • Tobin MJ, Cook PJ, Hutchison DC. Alpha 1 antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z. A survey by the British Thoracic Association. Br J Dis Chest 1983; 77: 14-27.
    • (1983) Br. J. Dis. Chest , vol.77 , pp. 14-27
    • Tobin, M.J.1    Cook, P.J.2    Hutchison, D.C.3
  • 18
    • 0028811087 scopus 로고
    • Decline in FEV1 among patients with severe hereditary alpha 1-antitrypsin deficiency type PiZ
    • Seersholm N, Kok-Jensen A, Dirksen A. Decline in FEV1 among patients with severe hereditary alpha 1-antitrypsin deficiency type PiZ. Am J Respir Crit Care Med 1995; 152: 1922-1925.
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 1922-1925
    • Seersholm, N.1    Kok-Jensen, A.2    Dirksen, A.3
  • 19
    • 0032586927 scopus 로고    scopus 로고
    • Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ)
    • Piitulainen E, Eriksson S. Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ). Eur Respir J 1999; 13: 247-251.
    • (1999) Eur. Respir. J. , vol.13 , pp. 247-251
    • Piitulainen, E.1    Eriksson, S.2
  • 20
    • 0030446288 scopus 로고    scopus 로고
    • Clinical features of individuals with PI*SZ phenotype of alpha 1-antitrypsin deficiency
    • Alpha 1-Antitrypsin Deficiency Registry Study Group
    • Turino GM, Barker AF, Brantly ML, et al. Clinical features of individuals with PI*SZ phenotype of alpha 1-antitrypsin deficiency. Alpha 1-Antitrypsin Deficiency Registry Study Group. Am J Respir Crit Care Med 1996; 154: 1718-1725.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154 , pp. 1718-1725
    • Turino, G.M.1    Barker, A.F.2    Brantly, M.L.3
  • 21
    • 0022379934 scopus 로고
    • Effects of smoking and intermediate alpha 1-antitrypsin deficiency (PiMZ) on lung function
    • Eriksson S, Lindell SE, Wiberg R. Effects of smoking and intermediate alpha 1-antitrypsin deficiency (PiMZ) on lung function. Eur J Respir Dis 1985; 67: 279-285.
    • (1985) Eur. J. Respir. Dis. , vol.67 , pp. 279-285
    • Eriksson, S.1    Lindell, S.E.2    Wiberg, R.3
  • 22
    • 0017623428 scopus 로고
    • Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men
    • Larsson C, Eriksson S, Dirksen H. Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men. Br Med J 1977; 2: 922-925.
    • (1977) Br. Med. J. , vol.2 , pp. 922-925
    • Larsson, C.1    Eriksson, S.2    Dirksen, H.3
  • 24
    • 0033979879 scopus 로고    scopus 로고
    • Risk of hospital admission for obstructive pulmonary disease in alpha(1)-antitrypsin heterozygotes of phenotype PiMZ
    • Seersholm N, Wilcke JT, Kok-Jensen A, Dirksen A. Risk of hospital admission for obstructive pulmonary disease in alpha(1)-antitrypsin heterozygotes of phenotype PiMZ. Am J Respir Crit Care Med 2000; 161: 81-84.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , pp. 81-84
    • Seersholm, N.1    Wilcke, J.T.2    Kok-Jensen, A.3    Dirksen, A.4
  • 25
    • 6344238675 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease in {alpha}1-antitrypsin PI MZ heterozygotes: A meta-analysis
    • Hersh CP, Dahl M, Ly NP, Berkey CS, Nordestgaard BG, Silverman EK. Chronic obstructive pulmonary disease in {alpha}1-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax 2004; 59: 843-849.
    • (2004) Thorax , vol.59 , pp. 843-849
    • Hersh, C.P.1    Dahl, M.2    Ly, N.P.3    Berkey, C.S.4    Nordestgaard, B.G.5    Silverman, E.K.6
  • 27
    • 0030963534 scopus 로고    scopus 로고
    • Effect of age and occupational exposure to airway irritants on lung function in non-smoking individuals with alpha 1-antitrypsin deficiency (PiZZ)
    • Piitulainen E, Tornling G, Eriksson S. Effect of age and occupational exposure to airway irritants on lung function in non-smoking individuals with alpha 1-antitrypsin deficiency (PiZZ). Thorax 1997; 52: 244-248.
    • (1997) Thorax , vol.52 , pp. 244-248
    • Piitulainen, E.1    Tornling, G.2    Eriksson, S.3
  • 28
    • 0031791367 scopus 로고    scopus 로고
    • Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with alpha1-antitrypsin deficiency
    • Piitulainen E, Sveger T. Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with alpha1-antitrypsin deficiency. Acta Paediatr 1998; 87: 1120-1124.
    • (1998) Acta Paediatr. , vol.87 , pp. 1120-1124
    • Piitulainen, E.1    Sveger, T.2
  • 29
    • 0031729205 scopus 로고    scopus 로고
    • Environmental correlates of impaired lung function in non-smokers with severe alpha 1-antitrypsin deficiency (PiZZ)
    • Piitulainen E, Tornling G, Eriksson S. Environmental correlates of impaired lung function in non-smokers with severe alpha 1-antitrypsin deficiency (PiZZ). Thorax 1998; 53: 939-943.
    • (1998) Thorax , vol.53 , pp. 939-943
    • Piitulainen, E.1    Tornling, G.2    Eriksson, S.3
  • 31
    • 0017295594 scopus 로고
    • Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population
    • Cole RB, Nevin NC, Blundell G, Merrett JD, McDonald JR, Johnston WP. Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population. Thorax 1976; 31: 149-157.
    • (1976) Thorax , vol.31 , pp. 149-157
    • Cole, R.B.1    Nevin, N.C.2    Blundell, G.3    Merrett, J.D.4    McDonald, J.R.5    Johnston, W.P.6
  • 32
    • 0017870918 scopus 로고
    • Pi phenotypes and the prevalence of chest symptoms and lung function abnormalities in workers employed in dusty industries
    • Chan-Yeung M, Ashley MJ, Corey P, Maledy H. Pi phenotypes and the prevalence of chest symptoms and lung function abnormalities in workers employed in dusty industries. Am Rev Respir Dis 1978; 117: 239-245.
    • (1978) Am. Rev. Respir. Dis. , vol.117 , pp. 239-245
    • Chan-Yeung, M.1    Ashley, M.J.2    Corey, P.3    Maledy, H.4
  • 33
    • 0018200006 scopus 로고
    • Alpha1-antitrypsin phenotypes and lung function in a moderately polluted northern Ontario community
    • Ostrow DN, Manfreda J, Dorman T, Cherniack RM. Alpha1-antitrypsin phenotypes and lung function in a moderately polluted northern Ontario community. Can Med Assoc J 1978; 118: 669-672.
    • (1978) Can. Med. Assoc. J. , vol.118 , pp. 669-672
    • Ostrow, D.N.1    Manfreda, J.2    Dorman, T.3    Cherniack, R.M.4
  • 34
    • 0018875674 scopus 로고
    • Alpha-1-antitrypsin types and chronic obstructive lung disease in an industrial community in Northern Sweden
    • Beckman G, Beckman L, Mikaelsson B, Rudolphi O, Stjernberg N, Wiman LG. Alpha-1-antitrypsin types and chronic obstructive lung disease in an industrial community in Northern Sweden. Hum Hered 1980; 30: 299-306.
    • (1980) Hum. Hered. , vol.30 , pp. 299-306
    • Beckman, G.1    Beckman, L.2    Mikaelsson, B.3    Rudolphi, O.4    Stjernberg, N.5    Wiman, L.G.6
  • 35
    • 0021691016 scopus 로고
    • Alpha-1-antitrypsin types and pulmonary disease among employees at a sulphite pulp factory in northern Sweden
    • Stjernberg N, Beckman G, Beckman L, Nystrom L, Rosenhall L. Alpha-1-antitrypsin types and pulmonary disease among employees at a sulphite pulp factory in northern Sweden. Hum Hered 1984; 34: 337-342.
    • (1984) Hum. Hered. , vol.34 , pp. 337-342
    • Stjernberg, N.1    Beckman, G.2    Beckman, L.3    Nystrom, L.4    Rosenhall, L.5
  • 37
    • 0023919117 scopus 로고
    • Respiratory symptoms and pulmonary function in 871 miners according to Pi phenotype: A longitudinal study
    • Pierre F, Pham QT, Mur JM, Chau N, Martin JP. Respiratory symptoms and pulmonary function in 871 miners according to Pi phenotype: a longitudinal study. Eur J Epidemiol 1988; 4: 39-44.
    • (1988) Eur. J. Epidemiol. , vol.4 , pp. 39-44
    • Pierre, F.1    Pham, Q.T.2    Mur, J.M.3    Chau, N.4    Martin, J.P.5
  • 38
    • 0028180104 scopus 로고
    • Low normal alpha-1-antitrypsin serum concentrations and MZ-phenotype are associated with byssinosis and familial allergy in cotton mill workers
    • Sigsgaard T, Brandslund I, Rasmussen JB, Lund ED, Varming H. Low normal alpha-1-antitrypsin serum concentrations and MZ-phenotype are associated with byssinosis and familial allergy in cotton mill workers. Pharmacogenetics 1994; 4: 135-141.
    • (1994) Pharmacogenetics , vol.4 , pp. 135-141
    • Sigsgaard, T.1    Brandslund, I.2    Rasmussen, J.B.3    Lund, E.D.4    Varming, H.5
  • 39
    • 0033624634 scopus 로고    scopus 로고
    • S and Z alpha1-antitrypsin alleles are risk factors for bronchial hyperresponsiveness in young farmers: An example of gene/environment interaction
    • Sigsgaard T, Brandslund I, Omland O, et al. S and Z alpha1-antitrypsin alleles are risk factors for bronchial hyperresponsiveness in young farmers: an example of gene/environment interaction. Eur Respir J 2000; 16: 50-55.
    • (2000) Eur. Respir. J. , vol.16 , pp. 50-55
    • Sigsgaard, T.1    Brandslund, I.2    Omland, O.3
  • 40
    • 18644375366 scopus 로고    scopus 로고
    • Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos
    • Lafuente MJ, Casterad X, Laso N, et al. Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos. Toxicol Lett 2002; 136: 9-17.
    • (2002) Toxicol. Lett. , vol.136 , pp. 9-17
    • Lafuente, M.J.1    Casterad, X.2    Laso, N.3
  • 41
    • 0035991331 scopus 로고    scopus 로고
    • Lung function of school children with low levels of alpha1-antitrypsin and tobacco smoke exposure
    • von Ehrenstein OS, von Mutius E, Maier E, et al. Lung function of school children with low levels of alpha1-antitrypsin and tobacco smoke exposure. Eur Respir J 2002; 19: 1099-1106.
    • (2002) Eur. Respir. J. , vol.19 , pp. 1099-1106
    • von Ehrenstein, O.S.1    von Mutius, E.2    Maier, E.3
  • 42
    • 0037341701 scopus 로고    scopus 로고
    • Passive smoking and lung function in alpha(1)-antitrypsin heterozygote schoolchildren
    • Corbo GM, Forastiere F, Agabiti N, et al. Passive smoking and lung function in alpha(1)-antitrypsin heterozygote schoolchildren. Thorax 2003; 58: 237-241.
    • (2003) Thorax , vol.58 , pp. 237-241
    • Corbo, G.M.1    Forastiere, F.2    Agabiti, N.3
  • 43
    • 7744223457 scopus 로고    scopus 로고
    • Alpha1-antitrypsin as a risk for infant and adult respiratory outcomes in a national birth cohort
    • Wadsworth ME, Vinall LE, Jones AL, et al. Alpha1-antitrypsin as a risk for infant and adult respiratory outcomes in a national birth cohort. Am J Respir Cell Mol Biol 2004; 31: 559-564.
    • (2004) Am. J. Respir. Cell Mol. Biol. , vol.31 , pp. 559-564
    • Wadsworth, M.E.1    Vinall, L.E.2    Jones, A.L.3
  • 44
    • 0031589641 scopus 로고    scopus 로고
    • Mutation in an alpha1-antitrypsin enhancer results in an interleukin-6 deficient acute-phase response due to loss of cooperativity between transcription factors
    • Morgan K, Scobie G, Marsters P, Kalsheker NA. Mutation in an alpha1-antitrypsin enhancer results in an interleukin-6 deficient acute-phase response due to loss of cooperativity between transcription factors. Biochim Biophys Acta 1997; 1362: 67-76.
    • (1997) Biochim. Biophys. Acta , vol.1362 , pp. 67-76
    • Morgan, K.1    Scobie, G.2    Marsters, P.3    Kalsheker, N.A.4
  • 45
    • 0030610568 scopus 로고    scopus 로고
    • Pharmacokinetic study of alpha1-antitrypsin infusion in alpha1-antitrypsin deficiency
    • Barker AF, Iwata-Morgan I, Oveson L, Roussel R. Pharmacokinetic study of alpha1-antitrypsin infusion in alpha1-antitrypsin deficiency. Chest 1997; 112: 607-613.
    • (1997) Chest , vol.112 , pp. 607-613
    • Barker, A.F.1    Iwata-Morgan, I.2    Oveson, L.3    Roussel, R.4
  • 46
    • 0026000815 scopus 로고
    • Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes
    • Brantly ML, Wittes JT, Vogelmeier CF, Hubbard RC, Fells GA, Crystal RG. Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes. Chest 1991; 100: 703-708.
    • (1991) Chest , vol.100 , pp. 703-708
    • Brantly, M.L.1    Wittes, J.T.2    Vogelmeier, C.F.3    Hubbard, R.C.4    Fells, G.A.5    Crystal, R.G.6
  • 47
    • 19944430698 scopus 로고    scopus 로고
    • Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo
    • Mahadeva R, Atkinson C, Li Z, et al. Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol 2005; 166: 377-386.
    • (2005) Am. J. Pathol. , vol.166 , pp. 377-386
    • Mahadeva, R.1    Atkinson, C.2    Li, Z.3
  • 48
    • 0025022347 scopus 로고
    • Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele
    • Curiel DT, Vogelmeier C, Hubbard RC, Stier LE, Crystal RG. Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele. Mol Cell Biol 1990; 10: 47-56.
    • (1990) Mol. Cell Biol. , vol.10 , pp. 47-56
    • Curiel, D.T.1    Vogelmeier, C.2    Hubbard, R.C.3    Stier, L.E.4    Crystal, R.G.5
  • 49
    • 2442488539 scopus 로고    scopus 로고
    • Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
    • Mulgrew AT, Taggart CC, Lawless MW, et al. Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest 2004; 125: 1952-1957.
    • (2004) Chest , vol.125 , pp. 1952-1957
    • Mulgrew, A.T.1    Taggart, C.C.2    Lawless, M.W.3
  • 50
    • 0023571643 scopus 로고
    • Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase
    • Hubbard RC, Ogushi F, Fells GA, et al. Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase. J Clin Invest 1987; 80: 1289-1295.
    • (1987) J. Clin. Invest. , vol.80 , pp. 1289-1295
    • Hubbard, R.C.1    Ogushi, F.2    Fells, G.A.3
  • 51
    • 0023102865 scopus 로고
    • Effect of smoking on functional activity of plasma alpha 1-protease inhibitor
    • Fera T, Abboud RT, Johal SS, Richter AM, Gibson N. Effect of smoking on functional activity of plasma alpha 1-protease inhibitor. Chest 1987; 91: 346-530.
    • (1987) Chest , vol.91 , pp. 346-530
    • Fera, T.1    Abboud, R.T.2    Johal, S.S.3    Richter, A.M.4    Gibson, N.5
  • 52
    • 0025897211 scopus 로고
    • Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase
    • Ogushi F, Hubbard RC, Vogelmeier C, Fells GA, Crystal RG. Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase. J Clin Invest 1991; 87: 1060-1065.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1060-1065
    • Ogushi, F.1    Hubbard, R.C.2    Vogelmeier, C.3    Fells, G.A.4    Crystal, R.G.5
  • 53
    • 0027960084 scopus 로고
    • Regulation of the alpha 1-antitrypsin gene and a disease-associated mutation in a related enhancer sequence
    • Kalsheker NA, Morgan K. Regulation of the alpha 1-antitrypsin gene and a disease-associated mutation in a related enhancer sequence. Am J Respir Crit Care Med 1994; 150: S183-S189.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150
    • Kalsheker, N.A.1    Morgan, K.2
  • 54
    • 0034117111 scopus 로고    scopus 로고
    • Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin
    • Dhami R, Gilks B, Xie C, Zay K, Wright JL, Churg A. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin. Am J Respir Cell Mol Biol 2000; 22: 244-252.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.22 , pp. 244-252
    • Dhami, R.1    Gilks, B.2    Xie, C.3    Zay, K.4    Wright, J.L.5    Churg, A.6
  • 56
    • 0034596496 scopus 로고    scopus 로고
    • Public-health impact of outdoor and traffic-related air pollution: A European assessment
    • Kunzli N, Kaiser R, Medina S, et al. Public-health impact of outdoor and traffic-related air pollution: a European assessment. Lancet 2000; 356: 795-801.
    • (2000) Lancet , vol.356 , pp. 795-801
    • Kunzli, N.1    Kaiser, R.2    Medina, S.3
  • 57
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Project. Nature 2003; 426: 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 58
    • 0027989694 scopus 로고
    • Physical and genetic mapping of the serpin gene cluster at 14q32.1: Allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency
    • Byth BC, Billingsley GD, Cox DW. Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency. Am J Hum Genet 1994; 55: 126-133.
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 126-133
    • Byth, B.C.1    Billingsley, G.D.2    Cox, D.W.3
  • 59
    • 0033094269 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in alpha1-antitrypsin deficiency
    • Novoradovsky A, Brantly ML, Waclawiw MA, et al. Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol 1999; 20: 441-447.
    • (1999) Am. J. Respir. Cell Mol. Biol. , vol.20 , pp. 441-447
    • Novoradovsky, A.1    Brantly, M.L.2    Waclawiw, M.A.3
  • 60
    • 19844376460 scopus 로고    scopus 로고
    • Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD
    • Rodriguez F, de la Roza C, Jardi R, Schaper M, Vidal R, Miravitlles M. Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD. Chest 2005; 127: 1537-1543.
    • (2005) Chest , vol.127 , pp. 1537-1543
    • Rodriguez, F.1    de la Roza, C.2    Jardi, R.3    Schaper, M.4    Vidal, R.5    Miravitlles, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.