Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in α1-antitrypsin deficiency

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 3, 1999, Pages 441-447

  Novoradovsky, Alexey ^a   Brantly, Mark L ^a   Waclawiw, Myron A ^a   Chaudhary, Prerna P ^a   Ihara, Hideshi ^a   Qi, Lin ^a   Eissa, N Tony ^a   Barnes, Pauline M ^a   Gabriele, Kateri M ^a   Ehrmantraut, Mary E ^a   Rogliani, Paola ^a   Moss, Joel ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; DISEASE PREDISPOSITION; DNA SEQUENCE; EMPHYSEMA; ENZYMOLOGY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MIDDLE AGED;

ADULT; ALPHA 1-ANTITRYPSIN DEFICIENCY; DISEASE SUSCEPTIBILITY; EMPHYSEMA; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 0033094269     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.3.3144     Document Type: Article

References (19)

1. Moncada, S., R. M. J. Palmer, and E. A. Higgs. 1991. NO: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:109-142.
2. Sessa, W., G. Garcia-Cardena, J. Liu, A. Keh, J. S. Pollock, J. Bradley, S. Thiru, I. M. Braverman, and K. M. Desai. 1995. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J. Biol. Chem. 270:17641-17644.
3. Garcia-Cardena, G., P. Oh, J. Liu, J. E. Schnitzer, and W. Sessa. 1996. Targeting of nitric oxide synthase to endothelial cell caveolac via palmitoylation: implications for nitric oxide signalling. Proc. Natl. Acad. Sci. USA 93:6448-6453.
4. Shaul, P. W., E. J. Smart, L. J. Robinson, Z. German, T. S. Yuhanna, Y. Ying, R. G. W. Anderson, and T. Michel. 1996. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J. Biol. Chem. 271: 6518-6522.
5. Feron, O., L. Belhassen, L. Kobzik, T. W. Smith, R. A. Kelly, and T. Michel. 1996. Endothelial nitric oxide synthase targeting to caveolae. J. Biol. Chem. 271:22810-22814.
6. Wang, X. L., A. S. Sim, R. F. Badenhop, R. M. McCredie, and D. E. Wilcken. 1996. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat. Med. 2:41-45.
7. Bonnardeaux, A., S. Nadaud, A. Charru, X. Jeunemaitre, P. Corvol, and F. Soubrier. 1995. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation 91:96-102.
8. Nijkamp, F. P., and G. Folkerts. 1994. Nitric oxide and bronchial reactivity. Clin. Exp. Allergy 24:905-914.
9. Barnes, P. J., and M. G. Belvisi. 1993. Nitric oxide and lung disease. Thorax 48:1034-1043.
10. Yamamoto, Y., R. Sawa, N. Okamoto, A. Matsui, M. Yanagisawa, and S. Ikemoto. 1986. Deletion 14q (q24.3 to q32.1) syndrome: significance of peculiar facial appearance in its diagnosis, and deletion mapping of Pi (alpha-1-antitrypsin). Hum. Genet. 74:190-192.
11. Brantly, M. L., L. D. Paul, B. H. Miller, R. T. Falk, M. Wu, and R. Crystal. 1988. Clinical features and history of the destructive lung disease associated with α-1-antitrypsin deficiency of adults with pulmonary symptoms. Am. Rev. Respir. Dis. 138:327-336.
12. Silverman, E. K., M. A. Province, E. J. Camphell, J. A. Pierce, and D. C. Rao. 1990. Variability of pulmonary function in alpha-1-antitrypsin deficiency: residual family resemblance beyond the effect of the Pi locus. Hum. Hered. 40:340-355.
13. McElvaney, N. G., J. K. Stoller, A. S. Buist, U. B. S. Prakash, M. L. Brantly, M. D. Schluchter, and R. D. Crystal. 1997. Base-line characteristics of enrollees in the National Heart, Lung and Blood Institute registry of alpha(1)-antitrypsin deficiency. Chest 111:394-403.
14. Orita, M., H. Iwahana, H. Kanarawa, K. Hayashi, and T. Sekiya. 1989. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. USA 86:2766-2770.
15. Fischer, S. G., and L. S. Lerman. 1983. DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. Proc. Natl. Acad. Sci. USA 80:1579-1583.
16. Emery, A. E. H., editor. 1986. Methodology in Medical Genetics: An Introduction to Statistical Methods. Churchill Livingstone, Edinburgh.
17. Hedrick, P. W. 1985. Genetics of Populations. Jones and Bartlett, Boston.
18. Morris, J. A., and M. J. Gardner. 1988. Calculating confidence intervals for relative risks (odds ratios) and standardized ratios and rates. B.M.J. 296: 1313-1316.
19. Marsden, P. A., H. H. Heng, S. W. Scherer, R. J. Stewart, A. V. Hall, X.-M. Shi, L.-C. Tsui, and K. T. Schappert. 1993. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J. Biol. Chem. 268:17478-17488.