Interactions of charged ligands with β2-microglobulin conformers in affinity capillary electrophoresis

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1753, Issue 1, 2005, Pages 131-140

  Heegaard, Niels H H ^a   Lorenzi, Ersilia De ^b  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

2 microglobulin; Affinity; Amyloid; Capillary electrophoresis; Protein conformation

Indexed keywords

BETA 2 MICROGLOBULIN; CONGO RED; COPPER; HEPARIN; LIGAND; SURAMIN;

CAPILLARY ELECTROPHORESIS; CHEMICAL BINDING; CHEMICAL REACTION; COMPARATIVE STUDY; CONFERENCE PAPER; EXPERIMENTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; SEPARATION TECHNIQUE;

AMYLOID; BETA 2-MICROGLOBULIN; CONGO RED; COPPER; ELECTROPHORESIS, CAPILLARY; HEPARIN; LIGANDS; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; SURAMIN;

EID: 27744451208     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.07.005     Document Type: Conference Paper

References (37)

1. 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis J.Biol.Chem. 276 2001 46714 46721
2. F. Chiti, P. Mangione, A. Andreola, S. Giorgetti, M. Stefani, C.M. Dobson, V. Bellotti, and N. Taddei Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin J. Mol. Biol. 307 2001 379 391
3. A. Corazza, F. Pettirossi, P. Viglino, G. Verdone, J. Garcia, P. Dumy, S. Giorgetti, P. Mangione, S. Raimondi, M. Stoppini, V. Bellotti, and G. Esposito Properties of some variants of human beta2-microglobulin and amyloidogenesis J. Biol.Chem. 279 2004 9176 9189
4. D.B. Corlin, J.W. Sen, S. Ladefoged, G.B. Lund, M.H. Nissen, and N.H. Heegaard Quantification of cleaved {beta}2-microglobulin in serum from patients undergoing chronic hemodialysis Clin. Chem. 51 2005 1177 1184
5. E. De Lorenzi, S. Giorgetti, S. Grossi, G. Merlini, G. Caccialanza, and V. Bellotti Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease" Curr. Med. Chem. 11 2004 1065 1084
6. E. De Lorenzi, S. Grossi, G. Massolini, S. Giorgetti, P. Mangione, A. Andreola, F. Chiti, V. Bellotti, and G. Caccialanza Capillary electrophoresis investigation of a partially unfolded conformation of beta(2)-microglobulin Electrophoresis 23 2002 918 925
7. J. Dressel, and R.E. Oesper The discovery of Germanin by Oskar Dressel and Richard Kothe. J. Chem. Educ. 38 1961 620 621
8. C.M. Eakin, J.D. Knight, C.J. Morgan, M.A. Gelfand, and A.D. Miranker Formation of a copper specific binding site in non-native states of beta-2-microglobulin Biochemistry 41 2002 10646 10656
9. G. Esposito, R. Michelutti, G. Verdone, P. Viglino, H. Hernandez, C.V. Robinson, A. Amoresano, F. Dal Piaz, M. Monti, P. Pucci, P. Mangione, M. Stoppini, G. Merlini, G. Ferri, and V. Bellotti Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation Protein Sci. 9 2000 831 845
10. F. Gejyo, T. Ysmada, S. Odani, Y. Nakagawa, M. Arakawa, T. Kunitomoto, H. Kataoka, M. Suzuki, Y. Hirasawa, and T. Shirahama A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin Biochem. Biophys. Res. Commun. 129 1985 701 706
11. S. Gilch, K.F. Winklhofer, M.H. Groschup, M. Nunziante, R. Lucassen, C. Spielhaupter, W. Muranyi, D. Riesner, J. Tatzelt, and H.M. Schatzl Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease EMBO J. 20 2001 3957 3966
12. 2-microglobulin is an amyloidogenic protein in man. J. Clin. Invest. 76 1985 2425 2429
13. P.D. Grossman, J.C. Colburn, and H.K. Lauer A semiempirical model for the electrophoretic mobilities of peptides in free-solution capillary electrophoresis. Anal. Biochem. 179 1989 28 33
14. T.E. Hardingham, and A.J. Fosang Proteoglycans: many forms and many functions. FASEB J. 6 1992 861 870
15. N.H.H. Heegaard Applications of affinity interactions in capillary electrophoresis Electrophoresis 24 2003 3879 3891
16. N.H.H. Heegaard Capillary Electrophoresis S.E. Harding B.Z. Chowdhry 2001 Oxford UK 171 195
17. 2-microglobulin Biochemistry 44 2005 4397 4407
18. 2-microglobulin partially attains a conformation that has amyloidogenic features. J. Biol. Chem. 277 2002 11184 11189
19. 2-microglobulin characterized by capillary electrophoresis and complementary separation methods. J. Chromatogr., A 1004 2003 51 59
20. 2-microglobulin at neutral pH J. Biol. Chem. 276 2001 32657 32662
21. 2-microglobulin conformations characterized by dye affinity capillary electrophoresis J. Chromatogr., A 894 2000 319 327
22. V.J. Hilser, and E. Freire Quantitative analysis of conformational equilibrium using capillary electrophoresis: applications to protein folding Anal. Biochem. 224 1995 465 485
23. W.E. Klunk, J.W. Pettegrew, and D.J. Abraham Quantitative evaluation of Congo red binding to amyloid-like proteins with a beta-pleated sheet conformation J. Histochem. Cytochem. 37 1989 1273 1281
24. J.P. Landers Handbook of Capillary Electrophoresis 1997 CRC Press Boca Raton, FL
25. J. Lim, and R.W. Vachet Using mass spectrometry to study copper-protein binding under native and non-native conditions: beta-2-microglobulin Anal. Chem. 76 2004 3498 3504
26. R.M. Lozano, M. Jimenez, J. Santoro, M. Rico, and G. Gimenez-Gallego Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas J. Mol. Biol. 281 1998 899 915
27. V.J. McParland, N.M. Kad, A.P. Kalverda, A. Brown, P. Kirwin-Jones, M.G. Hunter, M. Sunde, and S.E. Radford Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro Biochemistry 39 2000 8735 8746
28. V.J. McParland, A.P. Kalverda, S.W. Homans, and S.E. Radford Structural properties of an amyloid precursor of beta(2)-microglobulin Nat. Struct. Biol. 9 2002 326 331
29. G. Merlini, and V. Bellotti Molecular mechanisms of amyloidosis N. Engl. J. Med. 349 2003 583 596
30. C.J. Morgan, M. Gelfand, C. Atreya, and A.D. Miranker Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation J. Mol. Biol. 309 2001 339 345
31. M.H. Nissen, P. Roepstorff, L. Thim, B. Dunbar, and J.E. Fothergill Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s Eur. J. Biochem. 189 1990 423 429
32. H. Ozasa, T. Suzuki, and K. Ota Modification of serum beta-2-microglobulin in chronic hemodialysis patients Nephron 53 1989 87
33. H. Puchtler, F. Sweat, and M. Levine On the binding of Congo red by amyloid J. Histochem. Cytochem. 10 1962 355 364
34. D.P. Smith, S. Jones, L.C. Serpell, M. Sunde, and S.E. Radford A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation J. Mol. Biol. 330 2003 943 954
35. A.D. Snow, J. Willmer, and R. Kisilevsky Sulfated glycosaminoglycans: a common constituent of all amyloids? Lab. Invest. 56 1987 120 123
36. G. Verdone, A. Corazza, P. Viglino, F. Pettirossi, S. Giorgetti, P. Mangione, A. Andreola, M. Stoppini, V. Bellotti, and G. Esposito The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition Protein Sci. 11 2002 487 499
37. J. Villanueva, M. Hoshino, H. Katou, J. Kardos, K. Hasegawa, H. Naiki, and Y. Goto Increase in the conformational flexibility of beta 2-microglobulin upon copper binding: a possible role for copper in dialysis-related amyloidosis Protein Sci. 13 2004 797 809