Modeling prognosis for patients with malignant astrocytic gliomas: Quantifying the expression of multiple genetic markers and clinical variables

Neuro-Oncology

Volumn 7, Issue 4, 2005, Pages 485-494

  Zhou, Yi Hong ^a,c   Hess, Kenneth R ^d   Liu, Longjian ^a,b,c   Linskey, Mark E ^e   Yung, W K Alfred ^d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Astrocytic gliomas; CDK4; Differential gene expression; IGFBP2; MMP2; Prognostic model; Real time quantitative RT PCR; RPS9

Indexed keywords

CYCLIN DEPENDENT KINASE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RIBOSOME PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR PAX6; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER PATIENT; CANCER SURVIVAL; CLINICAL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC MARKER; GENETIC MODEL; GENETIC VARIABILITY; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PROGNOSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; TUMOR DIFFERENTIATION;

ASTROCYTOMA; BRAIN NEOPLASMS; GENE EXPRESSION; GENETIC MARKERS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MATRIX METALLOPROTEINASE 2; MODELS, STATISTICAL; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 27644585644     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S1152851704000730     Document Type: Article

References (39)

1. Akaike, H. (1973) Information theory and an extension of the maximum likelihood principle. In Petrov, B.N., and Csáki, F. (Eds.), 2nd International Symposium on Information Theory. Budapest: Akadémiai Kiadó, 267-281.
2. Akmal, S.N., Yun, K., MacLay, J., Higami, Y., and Ikeda, T. (1995) Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma. Hum. Pathol. 26, 846-851.
3. Altman, D.G., Lausen, B., Sauerbrei, W., and Schumacher, M. (1994) Dangers of using "optimal" cutpoints in the evaluation of prognostic factors. J. Natl. Cancer Inst. 86, 829-835.
4. Brat, D.J., Castellano-Sanchez, A.A., Hunter, S.B., Pecot, M., Cohen, C., Hammond, E.H., Devi, S.N., Kaur, B., and Van Meir, E.G. (2004) Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res. 64, 920-927.
5. CBTRUS (2002) Primary Brain Tumors in the United States: Statistical Report, 1995-1999. Central Brain Tumor Registry of the United States. Available at http://www.cbtrus.org/reports/reports.html.
6. Crnogorac-Jurcevic, T., Efthimiou, E., Capelli, P., Blaveri, E., Baron, A., Terris, B., Jones, M., Tyson, K., Bassi, C., Scarpa, A., and Lemoine, N.R. (2001) Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 20, 7437-7346.
7. Daumas-Duport, C., Scheithauer, B., O'Fallon, J., and Kelly, P. (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62, 2152-2165.
8. Dirks, P.B., Hubbard, S.L., Murakami, M., and Rutka, J.T. (1997) Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines. J. Neuropathol. Exp. Neurol. 56, 291-300.
9. Fuller, G.N., Rhee, C.H., Hess, K.R., Caskey, L.S., Wang, R., Bruner, J.M., Yung, W.K., and Zhang, W. (1999) Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling. Cancer Res. 59, 4228-4232.
10. Harvey, A.C. (1981) Time Series Models. New York: John Wiley & Sons, Inc.
11. Godard, S., Getz, G., Delorenzi, M., Farmer, P., Kobayashi, H., Desbaillets, I., Nozaki, M., Diserens, A.C., Hamou, M.F., Dietrich, P.Y., Regli, L., Janzer, R.C., Bucher, P., Stupp, R., de Tribolet, N., Domany, E., and Hegi, M.E. (2003) Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res. 63, 6613-6625.
12. Katz, M.H. (1999) Multivariable Analysis. Cambridge: Cambridge University Press.
13. Kim, S.Y., Lee, M.Y., Cho, K.C., Choi, Y.S., Choi, J.S., Sung, K.W., Kwon, O.J., Kim, H.S., Kim, I.K., and Jeong, S.W. (2003) Alterations in mRNA expression of ribosomal protein S9 in hydrogen peroxide-treated neurotumor cells and in rat hippocampus after transient ischemia. Neurochem. Res. 28, 925-931.
14. Kleihues, P., and Cavenee, W.K. (2000) Pathology and Genetics of Tumours of the Nervous System. 2nd ed. Lyon: IARC Press.
15. Kon, H., Sonoda, Y., Kumabe, T., Yoshimoto, T., Sekiya, T., and Murakami, Y. (1998) Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas. Oncogene 16, 257-263.
16. Kordek, R., Biernat, W., Alwasiak, J., Maculewicz, R., Yanagihara, R., and Liberski, P.P. (1995) p53 protein and epidermal growth factor receptor expression in human astrocytomas. J. Neurooncol. 26, 11-16.
17. Koul, D., Parthasarathy, R., Shen, R., Davies, M.A., Jasser, S.A., Chintala, S.K., Rao, J.S., Sun, Y., Benvenisite, E.N., Liu, T.J., and Yung, W.K. (2001) Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20, 6669-6678.
18. Kuo, W.P., Jenssen, T.K., Butte, A.J., Ohno-Machado, L., and Kohane, I.S. (2002) Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics 18, 405-412.
19. Lam, P.Y., Di Tomaso, E., Ng, H.K., Pang, J.C., Roussel, M.F., and Hjelm, N.M. (2000). Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. Br. J. Neurosurg. 14, 28-32.
20. Lantos, P.L., VandenBerg, S.R., and Kleihues, P (1997) Tumours of the nervous system. In Graham, D.I., and Lantos, P.L., Eds., Greenfield's Neuropathology, Sixth Edition. London: Arnold.
21. Liu, W., James, C.D., Frederick, L., Alderete, B.E., and Jenkins, R.B. (1997) PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res. 57, 5254-5257.
22. McCawley, L.J., and Matrisian, L.M. (2001) Matrix metalloproteinases: They're not just for matrix anymore! Curr. Opin. Cell Biol. 13, 534-540.
23. Newcomb, E.W., Cohen, H., Lee, S.R., Bhalla, S.K., Bloom, J., Hayes, R.L., and Miller, D.C. (1998) Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. Brain Pathol. 8, 655-667.
24. Noel, A., Gilles, C., Bajou, K., Devy, L., Kebers, F., Lewalle, J.M., Maquoi, E., Munaut, C., Remacle, A., and Foidart, J.M. (1997) Emerging roles for proteinases in cancer. Invasion Metastasis 17, 221-239.
25. Rainov, N.G., Dobberstein, K.U., Bahn, H., Holzhausen, H.J., Lautenschlager, C., Heidecke, V., and Burkert, W. (1997) Prognostic factors in malignant glioma: Influence of the overexpression of oncogene and tumor-suppresser gene products on survival. J. Neurooncol. 35, 13-28.
26. Ransom, D.T., Ritland, S.R., Moertel, C.A., Dahl, R.J., O'Fallon, J.R., Scheithauer, B.W., Kimmel, D.W., Kelly, P.J., Olopade, O.I., Diaz, M.O., and Jenkins, R.B. (1992) Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo-astrocytomas. Genes Chromosomes Cancer 5, 357-374.
27. Rasheed, B.K., Fuller, G.N., Friedman, A.H., Bigner, D.D., and Bigner, S.H. (1992) Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes Cancer 5, 75-82.
28. Richardsen, E., Ukkonen, T., Bjornsen, T., Mortensen, E., Egevad, L., and Busch, C. (2003) Overexpression of IGBFB2 is a marker for malignant transformation in prostate epithelium. Virchows Arch. 442, 329-335.
29. Rollbrocker, B., Waha, A., Louis, D.N., Wiestler, O.D., and von Deimling, A. (1996) Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme. Acta Neuropathol. 92, 70-74.
30. Sallinen, S.L., Sallinen, P.K., Haapasalo, H.K., Helin, H.J., Helen, P.T., Schraml, P., Kallioniemi, O.P., and Kononen, J. (2000) Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res. 60, 6617-6622.
31. Sano, T., Lin, H., Chen, X., Langford, L.A., Koul, D., Bondy, M.L., Hess, K.R., Myers, J.N., Hong, Y.K., Yung, W.K., and Steck, P.A. (1999) Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis. Cancer Res. 59, 1820-1824.
32. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M. (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370, 61-65.
33. Shinojima, N., Tada, K., Shiraishi, S., Kamiryo, T., Kochi, M., Nakamura, H., Makino, K., Saya, H., Hirano, H., Kuratsu, J., Oka, K., Ishimaru, Y., and Ushio, Y. (2003) Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res. 63, 6962-6970.
34. Smith, J.S., Tachibana, I., Passe, S.M., Huntley, B.K., Borell, T.J., Iturria, N., O'Fallon, J.R., Schaefer, P.L., Scheithauer, B.W., James, C.D., Buckner, J.C., and Jenkins, R.B. (2001) PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J. Natl. Cancer Inst. 93, 1246-1256.
35. von Deimling, A., von Ammon, K., Schoenfeld, D., Wiestler, O.D., Seizinger, B.R., and Louis, D.N. (1993) Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol. 3, 19-26.
36. Wang, H., Wang, H., Shen, W., Huang, H., Hu, L., Ramdas, L., Zhou, Y.-H., Liao, W.S.-L., Fuller, G.N., and Zhang, W. (2003) Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res. 63, 4315-4321.
37. Wiltshire, R.N., Rasheed, B.K., Friedman, H.S., Friedman, A.H., and Bigner, S.H. (2000) Comparative genetic patterns of glioblastoma multiforme: Potential diagnostic tool for tumor classification. Neuro-Oncology 2, 164-173.
38. Zhou, Y.H., Tan, F., Hess, K.R., and Yung, W.K. (2003) The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: Relationship to tumor grade and survival. Clin. Cancer Res. 9, 3369-3375.
39. Zhou, Y.-H., Wu, X., Tan, F., Shi, Y.-X., Glass, T., Liu, T.J., Wathen, K., Hess, K.R., Gumin, J., Lang, F., and Yung, W.K.A. (2005) PAX6 suppresses growth of human glioblastoma cells. J. Neurooncol. 71, 223-229.