Failure of nitric oxide production by macrophages and decrease in CD4 + T cells in oral paracoccidioidomycosis: Possible mechanisms that permit local fungal multiplication

Revista do Instituto de Medicina Tropical de Sao Paulo

Volumn 47, Issue 5, 2005, Pages 267-273

  Batista, Aline Carvalho ^a   Soares, Cleverson Teixeira ^b   Lara, Vanessa Soares ^c,d  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b Sector of Microbiology   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d Edificio Barcelona ^*  (Brazil)

Author keywords

Immune cells; Nitric oxide; Paracoccidioidomycosis

Indexed keywords

CD20 ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

AGED; ANTIBODY LABELING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNGUS GROWTH; FUNGUS IMMUNITY; GIANT CELL; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; MONONUCLEAR CELL; MOUTH INFECTION; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS; PROTEIN EXPRESSION; SOUTH AMERICAN BLASTOMYCOSIS; T LYMPHOCYTE;

EID: 27644578206     PISSN: 00364665     EISSN: 16789946     Source Type: Journal    
DOI: 10.1590/S0036-46652005000500006     Document Type: Article

References (37)

1. ALBINA, J.E.; ABATE, J.A. & HENRY Jr., W.L. - Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of INF-γ in induction of the nitric oxide-synthesizing pathway. J. Immunol., 147: 144-148, 1991.
2. ALMEIDA, O.P.; JORGE, J.; SCULLY, C. & BOZZO, L. - Oral manifestations of paracoccidioidomycosis (South American blastomycosis). Oral Surg. Oral Med. Oral Path., 72: 430-435, 1991.
3. ALMEIDA, S.R. & LOPES, J.D. - The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response. Braz. J. med. biol. Res., 34: 529-537, 2001.
4. BATISTA, A.C.; SILVA, T.A.; CHUN, J.H. & LARA, V.S. - Nitric oxide synthesis and severity of human periodontal disease. Oral Dis., 8: 254-260, 2002.
5. BENARD, G.; ROMANO, C.C.; CACERE, C.R. et al. - Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. Cytokine, 13: 248-252, 2001.
6. BICALHO, R.N.; SANTO, M.F.D.; DE AGUIAR, M.C.F. & SANTOS, V.R. - Oral paracoccidioidomycosis: a retrospective study of 62 Brazilian patients. Oral Dis., 7: 56-60, 2001.
7. BOCCA, A.L.; HAYASHI, E.E.; PINHEIRO, A.G. et al. - Treatment of Paracoccidioides brasiliensis-infected mice with nitric oxide inhibitor prevents the failure of cell-mediated immune response. J. Immunol., 161: 3056-3063, 1998.
8. BOCCA, A.L.; SILVA, M.F.; SILVA, C.L.; CUNHA, F.Q. & FIGUEIREDO, F. - Macrophage expression of class II major histocompatibility complex gene products in Paracoccidioides brasiliensis-infected mice. Amer. J. trop. Med. Hyg, 61: 280-287, 1999.
9. BODIS, S. & HAREGEWOIN, A. - Significantly reduced salivary nitric oxide levels in smokers. Ann. Oncol., 5: 371-372, 1994.
10. BORGES-WALMSLEY, M.I.; CHEN, D.L.; SHU, X.H. & WALMSLEY, A.R. - The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol., 10: 80-87, 2002.
11. BRUMMER, E.; HANSON, L.H.; RESTREPO, A. & STEVENS, D.A. - Intracellular multiplication of Paracoccidioides brasiliensis in macrophages: killing and restriction of multiplication by activated macrophages. Infect. Immun., 57: 2289-2294, 1989.
12. BRUMMER, E.; SUN, S.H.; HARRISON, J.L. et al. - Ultrastructure of phagocytosed Paracoccidioides brasiliensis in nonactivated or activated macrophages. Infect. Immun., 58: 2628-2636, 1990.
13. CALICH, V.L.G. & KASHINO, S.S. - Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection. Braz. J. med. biol. Res., 31: 615-623, 1998.
14. CAMPANELLI, A.P.; MARTINS, G.A.; SOUTO, J.T. et al. - Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. J. infect. Dis., 187: 1496-1505, 2003.
15. CANO, L.E.; CASINO, S.S.; ARRUDA, C. et al. - Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis. Infect. Immun., 66: 800-806, 1998.
16. + T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis. Infect. Immun., 68: 352-359, 2000.
17. CAROSSA, S.; PERA, P.; DOGLIO, P. et al. - Oral nitric oxide during plaque deposition. Europ. J. clin. Invest., 31: 876-879, 2001.
18. CUNHA, F.Q.; MONCADA, S. & LIEW, F.Y. - Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem. Biophys. Res. Commun., 182: 1155-1159, 1992.
19. DING, A.; NATHAN, C.F.; GRAYEAR, J. et al. - Macrophage deactivating factor and transforming growth factor-β1, -β2 and -β3 inhibit induction of macrophage nitrogen oxide synthesis by INF-γ. J. Immunol., 145: 940-944, 1990.
20. FACCHETTI, A.; VERMI, W.; FIORENTINI, S. et al. - Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. Amer. J. Path., 154: 145-152, 1999.
21. GONZALEZ, A.; GREGORI, W.; VELEZ, D.; RESTREPO, A. & CANO, L.E. - Nitric oxide participation in the fungicidal mechanism of gamma interferon-activated murine macrophages against Paracoccidioides brasiliemis conidia. Infect. Immun., 68: 2546-2552, 2000.
22. KARHAWI, A.S.K.; COLOMBO, A.L. & SALOMÃO, R. - Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission. Med. Mycol., 38: 225-229, 2000.
23. KASHINO, S.S.; FAZIOLI, R.A.; CAFALLI-FAVATI, C. et al. - Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of INF-γ production. J. Interferon Cytokine Res., 20: 89-97, 2000.
24. KENDALL, H.K.; MARSHALL, R.I. & BARTOLD, P.M. - Nitric oxide and tissue destruction. Oral Dis., 7: 2-10, 2001.
25. KHARITONOV, S.A.; ROBBINS, R.A.; YATES, D.; KEATINGS, V. & BARNES, P.J. - Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Amer. J. resp. Crit. Care Med., 152: 609-612, 1995.
26. LOCKSLEY, R.M.; PINGEL, S.; LACY, D. et al. - Susceptibility to infectious diseases: Leishmania as a paradigm. J. infect Dis., 179 (suppl. 2): S305-S308, 1999.
27. MAMONI, R.L.; NOUER, S.A.; OLIVEIRA, S.J. et al. - Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients with the juvenile form of paracoccidioidomycosis. Med. Mycol., 40: 153-159, 2002.
28. MARQUES MELLO, L.; SILVA-VERGARA, M.L. & RODRIGUES, V. - Patients with active infection with Paracoccidioides brasiliensis present a Th2 immune response characterized by high interleukin-4 and interkeukin-5 production. Hum. Immunol., 63: 149-154, 2002.
29. MOSCARDI-BACCHI, M.; SOARES, A.; MENDES, R.; MARQUES, S. & FRANCO, M. - In situ localization of T lymphocytes subsets in human paracoccidioidomycosis. J. med. vet Mycol., 27: 149-158, 1989.
30. MOTA, N.G.S.; REZKALLAH-IWASSO, M.T.; PERAÇOLI, M.T.S. et al. - Correlation between cell-mediated immunity and clinical forms of paracoccidioidomycosis. Trans. roy. Soc. trop. Med. Hyg., 79: 765-772, 1985.
31. NASCIMENTO, F.R.F.; CALICH, V.L.G.; RODRIGUEZ, D. & RUSSO, M. - Dual role of nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility. J. Immunol., 168: 4593-4600, 2002.
32. NEWORAL, E.P.M.; ALTEMANI, A.; MAMONI, R.L.; NORONHA, I.L. & BLOTTA, M.H.S.L. - Immunocytochemical localization of cytokines and inducible nitric oxide synthase (iNOS) in oral mucosa and lymph nodes of patients with paracoccidioidomycosis. Cytokine, 21: 234-241, 2003.
33. OLIVEIRA, S.J.; MAMONI, R.L.; MUSATTI, C.C.; PAPAIORDANOU, P.M.O. & BLOTTA, M.H.S.L. - Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. Microbes Infect, 4: 139-144, 2002.
34. SICHER, S.C.; VAZQUEZ, M.A. & LU, C.Y. -Inhibition of macrophages la expression by nitric oxide. J. Immunol., 153: 1293-1300, 1994.
35. SOUTO, J.T.; ALIBERTI, J.C.; CAMPANELLI, A.P. et al. - Chemokine production and leukocyte recruitment to the lung of Paracoccidioides brasiliensis-infected mice is modulated by Interferon-γ. Amer. J. Path., 163: 583-590, 2003.
36. SOUTO, J.T.; FIGUEIREDO, F; FURLANETTO, A. et al. - Interferon-γ and tumor necrosis factor-α determine resistance to Paracoccidioides brasiliensis infection in mice. Amer. J. Path., 156: 1811-1820, 2000.
37. VAN DER VEEN, R.C.; DIETLIN, T.A.; PEN, L. & GRAY, J.D. - Nitric oxide inhibits the proliferation of T-helper 1 and 2 lymphocytes without reduction in cytokine secretion. Cell Immunol., 193: 194-201, 1999.