Production of IFN-γ is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission

Medical Mycology

Volumn 38, Issue 3, 2000, Pages 225-229

  Karhawi, A S K ^a   Colombo, A L ^a   Salomão, Reinaldo ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

IFN ; IL 10; Paracoccidioidomycosis; Tumour necrosis factor

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BLOOD; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; MALE; MONONUCLEAR CELL; PARACOCCIDIOIDES BRASILIENSIS; SOUTH AMERICAN BLASTOMYCOSIS;

PARACOCCIDIOIDES BRASILIENSIS;

EID: 0034094535     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/mmy.38.3.225.229     Document Type: Article

References (17)

1. Restrepo A. Paracoccidioides brasiliensis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 4th edn. New York: Churchill Livingstone, 1995: 2386-2389.
2. Mendes NF, Musatti CC, Leão RC, Mendes E, Naspitz CK. Lymphocyte cultures and skin allograft survival in patients with South American blastomycosis. J Allergy Clin Immunol 1971; 48: 40-45.
3. Restrepo A, Restrepo M, Restrepo F, Aristizábal LH, Moncada LH, Velez H. Immune response in paracoccidioidomycosis. A controlled study of 16 patients before and after treatment. Sabouraudia 1978; 16: 151-163.
4. Mota NGS, Peracoli MTS, Mendes RP. et al. Mononuclear cell subsets in patients with different clinical forms of paracoccidioidomycosis. J Med Vet Mycol 1988; 26: 105-111.
5. Mosmann TR, Schumacher JH, Street NF, et al. Diversity of cytokine synthesis and function of mouse CD4 + T cells. Immunol Rev 1991; 123: 209-229.
6. Sher A, Gazzinelli RT, Oswald IP, et al. Role of T-cell derived cytokines in the downregulation of immune response in parasitic and retroviral infection. Immunol Rev 1992; 127: 183-204.
7. Moscardi-Bacchi M, Brummer E, Stevens DA. Support of Paracoccidioides brasiliensis multiplication by human monocytes or macrophages: inhibition by activated phagocytes. J Med Microbiol 1994; 40: 159-164.
8. Brummer E, Hanson LH, Stevens DA. Gamma-interferon activation of macrophages for killing of Paracoccidioides brasiliensis and evidence for nonoxidative mechanisms. Int J Immunopharmac 1988; 10: 945-952.
9. Gazzinelli RT, Oswald IP, James SL, Sher A. IL-10 inhibits parasite killing and nitrogen production by IFN-γ activated macrophages. J Immunol 1992; 148: 1792-1796.
10. Franco M, Montenegro MR, Mendes RP, Marques SA, Dillon NL, Mota NGS. Paracoccidioidomycosis: A recently proposed classification of its clinical forms. Rev Soc Bras Med Trop 1987; 20: 129-132.
11. Camargo ZP, Unterkircher C, Campoy SP, Travassos LR. Production of Paracoccidioides brasiliensis exoantigen for immunodiffusion tests. J Clin Microbiol 1988; 26: 2147-2151.
12. Karhawi ASK, Granato CFH, Colombo AL, Salomão R. Circulating levels of tumor necrosis factor-α (TNF-α), and CD4 + and CD8 + T lymphocytes in patients with paracoccidioidomycosis during activity and after remission of the disease. Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapv-ICAAC, San Francisco, CA, USA, September 1995. Washington DC: American Society for Microbiology, 1995: 168.
13. Calich VLG, Singer-Vermes LM, Siqueira AM, Burger E. Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis strains. Br J Exp Pathol 1985; 66: 585-594.
14. Calich VLG, Kashino SS. Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection. Braz J Med Biol Res 1998; 31: 615-623.
15. Benard G, Hong MA, Del Negro GM, Batista L, Shikanay-Yasuda MA, Duarte AJS. Antigen-specific immunosuppression in paracoccidioidomycosis. Am J Trop Med Hyg 1996; 54: 7-12.
16. Kindler V, Sappino AP, Grau GE, Piguet PF, Vassalli P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989; 56: 731-740.
17. Bacellar O, Brodskyn C, Guerreiro J. et al. Interleukin-12 restores interferon-γ production and cytotoxic responses in visceral leishmaniasis. J Infect Dis 1996; 173: 1515-1518.