Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis

Journal of Hepatology

Volumn 28, Issue 3, 1998, Pages 514-517

  Fabris, Paolo ^a   Betterle, Corrado ^b   Greggio, Nella A ^c   Zanchetta, Renato ^b   Bosi, Emanuele ^d   Biasin, Maria Raffaella ^e   De Lalla, Fausto ^a  

^a SAN BORTOLO HOSPITAL   (Italy)

^b Institute of Semeiotica Medica   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e NONE

Author keywords

Autoimmunity; HCV; Insulin dependent diabetes mellitus; Side effects; IFN therapy

Indexed keywords

GLUTAMATE DECARBOXYLASE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN G; INSULIN; MICROSOME ANTIBODY; RECOMBINANT ALPHA2B INTERFERON; THYROID ANTIBODY; THYROTROPIN; VIRUS RNA;

ADULT; ALLELE; ARTICLE; AUTOIMMUNITY; CASE REPORT; CHRONIC HEPATITIS; DOSE RESPONSE; GENETIC SUSCEPTIBILITY; HEPATITIS C; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0032030743     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80328-0     Document Type: Article

References (16)

1. Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med. 331:1994;1428-1436.
2. Foulis AK, Farquharson MA, Meager A. Immunoreactive α-interferon in insulin secreting β-cells in type I diabetes mellitus. Lancet. ii:1987;1423-1427.
3. Pujol-Borrell R, Todd I, Doshi M, Gray D, Feldmann M, Bottazzo GF. Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol. 65:1986;128-139.
4. Stewart TA, Hultgren B, Huang X, Pitts-Meek S, Hully J, MacLanchlan NJ. Induction of type I diabetes by interferon-α in transgenic mice. Science. 260:1993;1942-1946.
5. Fabris P, Betterle C, Floreani A, Greggio NA, De Lazzari F, Naccarato R, et al. Development of type 1 diabetes mellitus during interferon-α therapy for chronic HCV hepatitis. Lancet. 340:1992;548.
6. Gross U, Seifert E. Passagerer insulinpflichtiger Diabetes mellitus under Alpha-Interferontherapie bei chronisch aktiver Hepatitis. Z Gastroenterol. 31:1993;609-611.
7. Guerci AP, Guerci B, Lovy-Marshall C, Ongagna J, Ziegler O, Candilors H, et al. Onset of insulin-dependent diabetes mellitus after interferon alpha therapy for hair cell leukemia. Lancet. 343:1994;1167-1168.
8. Waguri M, Hanafusa T, Itoh N, Imagawa A, Miyagawa J, Kawata S, et al. Occurrence of IDDM during interferon therapy for chronic viral hepatitis. Diabetes Res Clin Pract. 23:1994;33-36.
9. Murakami M, Iriuchijima T, Mori M. Diabetes mellitus and interferon-α therapy. Ann Intern Med. 123:1995;318.
10. Gori A, Caredda F, Franzetti F, Ridolfo A, Ruscon F, Moroni M. Reversible diabetes in patients with AIDS-related Kaposi's sarcoma treated with interferon-α 2a. Lancet. 345:1994;1438-1439.
11. Giuntoli P, Mariani S, Avoli D, Giammarco V. Diabete mellito insulino-dipendente indotto da interferon-alfa. Minerva Endocrinol. 20:1995;243-245.
12. Whitehead RP, Hauschild A, Christophers E, Figlin R. Diabetes mellitus in cancer patients treated with combination interleukin 2 and α-interferon. Cancer Biother. 10:1995;45-49.
13. for the study of the liver Fattovich G, Giustina G, Favarato S, Ruol A. A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol. 24:1996;34-87.
14. Okanoue T, Sakamoto S, Itoh Y, Minami M, Yasui K, Sakamoto M, et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol. 25:1996;283-291.
15. Vadheim MC, Rotter J. Genetics of diabetes mellitus. Alberti KGMM, De Fronzo H, Keen P, Zimmet P. International Textbook of Diabetes Mellitus. 1992;81-7 John Wiley & Sons, New York.
16. Koivisto VA, Peklonen R, Cantel K. Effect of interferon on glucose tolerance and insulin sensitivity. Diabetes. 38:1989;641-647.