Psychophysiological mediators of caregiver stress and differential cognitive decline

Psychology and Aging

Volumn 20, Issue 3, 2005, Pages 402-411

  Vitaliano, Peter P ^a,e   Yi, Joyce ^a,e   Phillips, Paul E M ^a,e   Echeverria, Diana ^b   Young, Heather ^c   Siegler, Ilene C ^d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Caregivers; Cognition; Hostility; Metabolic; Stress

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; INSULIN;

AGED; ALZHEIMER DISEASE; ANGINA PECTORIS; ARTICLE; BECK DEPRESSION INVENTORY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CAREGIVER; COGNITION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GLUCOSE BLOOD LEVEL; HAMILTON SCALE; HEALTH STATUS; HEART INFARCTION; HORMONE SUBSTITUTION; HOSTILITY; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PSYCHOPHYSIOLOGY; QUESTIONNAIRE; RADIOIMMUNOASSAY; REGRESSION ANALYSIS; SPOUSE; STATE TRAIT ANXIETY INVENTORY; STRESS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANXIETY; AROUSAL; BLOOD PRESSURE; CAREGIVERS; COGNITION DISORDERS; COST OF ILLNESS; DEPRESSION; ENERGY METABOLISM; FEMALE; FOLLOW-UP STUDIES; HOSTILITY; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PERSONALITY ASSESSMENT; PERSONALITY INVENTORY; PSYCHOMETRICS; PSYCHOPHYSIOLOGY; REFERENCE VALUES; RISK; SPOUSES; STRESS, PSYCHOLOGICAL;

EID: 27644540289     PISSN: 08827974     EISSN: None     Source Type: Journal    
DOI: 10.1037/0882-7974.20.3.402     Document Type: Article

References (92)

1. Airaksinen, E., Larsson, M., Lundberg, I., & Forsell, Y. (2004). Cognitive functions in depressive disorders: Evidence from a population-based study. Psychological Medicine, 34, 83-91.
2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
3. Appels, A., Hoppener, P., & Mulder, P. (1987). A questionnaire to assess premonitory symptoms of myocardial infarction. International Journal of Cardiology, 17, 15-24.
4. Arno, P. S., Levine, C., & Memmott, M. M. (1999). The economic value of informal caregiving. Health Affairs, 18, 182-188.
5. Arvanitakis, Z., Wilson, R., Bienias, J., Evans, D., & Bennett, D. (2004). Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of Neurology, 61, 661-666.
6. Ashendorf, L., Constantinou, M., & McCaffrey, R. J. (2004). The effect of depression and anxiety on the TOMM in community-dwelling older adults. Archives of Clinical Neuropsychology, 19, 125-130.
7. Barbas, H., & Blatt, G. J. (1995). Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey. Hippocampus, 5, 511-533.
8. Barefoot, J. C., Larsen, S., von der Leith, L., & Schroll, M. (1995). Hostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women. American Journal of Epidemiology, 142, 477-484.
9. Baumgarten, M., Battista, R. N., Infante-Rivard, C., Hanley, J. A., Becker, R., & Gauthier, S. (1992). The psychological and physical health of family members caring for an elderly person with dementia. Journal of Clinical Epidemiology, 45, 61-70.
10. Beck, A. T., & Beck, R. W. (1972). Screening depressed patients in family practice: A rapid technique. Postgraduate Medicine, 52, 81-85.
11. Beck, A. T., Steer, R. A., & Garbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8, 77-100.
12. Brand, N., Hanson, E., & Godaert, G. (2000). Chronic stress affects blood pressure and speed of short-term memory. Perceptual and Motor Skills, 91, 291-298.
13. Bremner, J. D. (1999). Does stress damage the brain? Biological Psychiatry, 45, 797-805.
14. Buchanan, T. W., Kern, S., Allen, J. S., Tranel, D., & Kirschbaum, C. (2004). Circadian regulation of cortisol after hippocampal damage in humans. Biological Psychiatry, 56, 651-656.
15. Carro, E., & Torres-Aleman, I. (2004). The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. European Journal of Pharmacology, 490, 127-133.
16. Cartwright, J. C., Archbold, P. G., Stewart, B. J., & Limandri, B. (1994). Enrichment processes in family caregiving to frail elders. Advances in Nursing Science, 17, 31-43.
17. Caswell, L., Vitaliano, P. P., Croyle, K., Scanlan, J. M., Zhang, J., & Daruwala, A. (2003). Negative associations of chronic stress and cognitive functioning in older adult spouse caregivers. Experimental Aging-Research, 29, 303-318.
18. Cavada, C., Company, T., Tejedor, J., Cruz-Rizzolo, R. J., & Reinoso-Suarez, F. (2000). The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cerebral Cortex, 10, 220-242.
19. Conrad, C. D., Galea, L. A., Kuroda, Y., & McEwen, B. S. (1996). Chronic stress impairs spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behavioral Neuroscience, 110, 1321-1334.
20. Cook, W. W., & Medley, D. M. (1954). Proposed hostility and pharisaic-virtue scales for the MMPI. Journal of Applied Psychology, 38, 414-418.
21. Coutinho, M., Gerstein, H. C., Wang, Y., & Yusuf, S. (1999). The relationships between glucose and incident cardiovascular events. Diabetes Care, 22, 233-240.
22. de Kloet, E. R., Oitzl, M. S., & Joels, M. (1999). Stress and cognition: Are corticosteroids good or bad guys? Trends in Neuroscience, 22, 422-426.
23. Desmond, D. W., Tatemichi, T. K., Paik, M., & Stern, Y. (1993). Risk factors for cerebrovascular disease as correlates of cognitive function in a stroke-free cohort. Archives of Neurology, 50, 162-166.
24. Douglass, A. B., Bornstein, R., Nino-Marcia, G., Keenan, S., Miles, L., Zarcone, V. P., et al. (1994). The Sleep Disorders Questionnaire I: Creation and multivariate structure of SDQ. Sleep, 17, 160-167.
25. Durkin, T. P., Messier, C., Deboer, P., & Westerink, B. H. C. (1992). Raised glucose levels enhance scopolamine-induced acetylcholine overflow from the hippocampus: An in vivo micro dialysis study in the rat. Behavioral Brain Research, 49, 181-188.
26. Echeverria, D., Aposhian, H. V., & Woods, J. S. (1998). Neurobehavioral effects from exposure to dental amalgam Hg: New distinctions between recent exposure and Hg body burden. Federation of American Societies for Experimental Biology Journal, 12, 971-980.
27. Elias, M. F., Wolf, P. A., D'Agostino, R. B., Cobb, J., & White, L. R. (1993). Untreated blood pressure level is inversely related to cognitive functioning: The Framingham study. American Journal of Epidemiology, 138, 353-364.
28. Gallagher, D., Wrabetz, A., Lovett, S., Del Maestro, S., & Rose, J. (1989). Depression and other negative affects in family caregivers. In E. Light & B. Lebowitz (Eds.), Alzheimer's disease treatment and family stress: Future directions of research (pp. 218-244). Washington, DC: U. S. Government Printing Office.
29. Haan, M. N., Shemanski, L., Jaqust, W. J., Manolio, T. A., & Kuller, L. (1999). The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. Journal of the American Medical Association, 282, 40-46.
30. Habib, R., McIntosh, A. R., Wheeler, M. A., & Tulving, E. (2003) Memory encoding and hippocampally-based novelty/familiarity discrimination networks. Neuropsychologia, 41, 271-290.
31. Haley, W. E., Levine, E. G., Brown, S. L., & Bartolucci, A. A. (1987). Stress, appraisal, coping, and social support as predictors of adaptational outcome among dementia caregivers. Psychology and Aging, 2, 323-330.
32. Hamilton, M. (1960). A rating scale for depression. Journal of Neurological and Neurosurgical Psychiatry, 23, 56-62.
33. Hanken, M. A. (1989). A study of physician performance in a physician oriented in-patient clinical record system. (Doctoral dissertation, University of Washington, 1989). Dissertation Abstracts International, 50, 3823.
34. Harwood, D. G., Barker, W. W., Cantillon, M., Loewenstein, D. A., Ownby, R., & Duara, R. (1998). Depressive symptomatology in first-degree family caregivers of Alzheimer disease patients: A cross-ethnic comparison. Alzheimer Disease and Associated Disorders, 12, 340-346.
35. Horner, H. C., Munck, A., & Lienhard, G. E. (1987). Dexamethasone causes translocation of glucose transporters from the plasma-membrane to an intracellular site in human-fibroblasts. Journal of Biological Chemistry, 262, 17696-17702.
36. Husain, M. M., Rush, A. J., Fink, M., Knapp, R., Petrides, G., Rummans, T., et al. (2004). Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): A consortium for research in ECT (CORE) report. Journal of Clinical Psychiatry, 65, 485-491.
37. Jelicic, M., & Bonke, B. (2001). Memory impairments following chronic stress? A critical review. European Journal of Psychiatry, 15, 225-232.
38. Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987). The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatrica Scandinavica, 76, 465-479.
39. King, A. C., Oka, R. K., & Young, D. R. (1994). Ambulatory blood pressure and heart rate responses to the stress of work and caregiving in older women. Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 49(6), M239-M245.
40. King, D. A., Caine, E. D., Conwell, Y., & Cox, C. (1991). The neuropsychology of depression in the elderly: A comparative study with normal aging and Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 3, 163-168.
41. Kizilbash, A. H., Vanderploeg, R. D., & Curtiss, G. (2002). The effects of depression and anxiety on memory performance. Archives of Clinical Neuropsychology, 17, 57-67.
42. Korte, S. M. (2001). Corticosteroids in relation to fear, anxiety and psychopathology. Neuroscience and Biobehavioral Reviews, 25, 117-142.
43. Kovacs, M., D. Goldston, D., & Iyengar, S. (1992). Intellectual development and academic performance of children with insulin-dependent diabetes mellitus. Developmental Psychology, 28, 676-684.
44. Lee, S., Kawachi, I., & Grodstein, F. (2004). Does caregiving stress affect cognitive function in older women? The Journal of Nervous and Mental Disease, 192, 51-57.
45. Leonard, B. E., & Song, C. (1997). Changes in the immune-endocrine interrelationships in anxiety and depression. Stress Medicine, 13, 217-227.
46. Levy, A., Dachir, S., Arvel, I., & Kadar, T. (1994). Aging, stress, and cognitive function. Annals of the New York Academy of Sciences, 717, 79-88.
47. Lupien, S., Lecours, A. R., Lussier, I., Schwartz, G., Nair, N. P. V., & Meaney, M. J. (1994). Basal cortisol levels and cognitive deficits in human aging. Journal of Neuroscience, 14, 2893-2903.
48. Mahoney, A. M., Dalby, J. T., & King, M. C. (1998). Cognitive failures and stress. Psychological Reports, 82, 1432-1434.
49. McEwen, B. S., & Magarinos, M. (1997). Stress effects on morphology and function of the hippocampus. Annals of the New York Academy of Sciences, 821, 271-284.
50. McEwen, B. S., & Sapolsky, R. (1995). Stress and cognitive function. Current Opinion Neurobiology, 5, 205-216.
51. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services task force on Alzheimer's disease. Neurology, 34, 939-944.
52. McNally, R. J., & Shin, L. M. (1995). Association of intelligence with severity of posttraumatic stress disorder symptoms in Vietnam combat veterans. American Journal of Psychiatry, 152, 936-938.
53. Newcomer, J. W., Craft, S., Hershey, T., Askins, K., & Bardgett, M. E. (1994). Glucocorticoid-induced impairment in declarative memory performance in adult humans. Journal of Neuroscience, 14, 2047-2053.
54. Norris, F. H., & Uhl, G. A. (1993). Chronic stress as a mediator of acute stress: The case of Hurricane Hugo. Journal of Applied Social Psychology, 23, 1263-1284.
55. Nyberg, L., Maitland, S. B., Ronnlund, M., Backman, L., Dixon, R. A., Wahlin, A., et al. (2003). Selective adult age differences in an age-invariant multifactor model of declarative memory. Psychology and Aging, 18, 149-160.
56. Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A., Hofman, A., & Breteler, M. M. (1999). Diabetes mellitus and the risk of dementia: The Rotterdam study. Neurology, 53, 1907-1909.
57. Park, D. C. (1996). Aging, health, and behavior: The interplay between basic and applied science. In R. J. Resnick & R. H. Rozensky (Eds.), Health psychology through the life span: Practice and research opportunities (pp. 59-75). Washington, DC: American Psychological Association.
58. Park, D. C., Davidson, N., Lautenschlager, G., Smith, A. D., Smith, P., & Hedden, T. (2002). Models of visuospatial and verbal memory across the adult life span. Psychology and Aging, 17, 299-320.
59. Park, D. C., Glass, J. M., Minear, M., & Crofford, L. J. (2001). Cognitive function in fibromyalgia Patients. Arthritis and Rheumatism, 44, 2125-2133.
60. Park, D. C., Welsh, R. C., Marshuetz, C., Gutchess, A. H., Mikels, J., Polk, T. A., et al. (2003). Working memory for complex scenes: Age differences in frontal and hippocampal activations. Journal of Cognitive Neuroscience, 15, 1122-1134.
61. Parkin, A. J. (1997). Human memory: Novelty, association and the brain. Current Biology, 7, R768-R769.
62. Peila, R., Rodriguez, B. L., & Launer, L. J. (2002). Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies, The Honolulu-Asia Aging Study. Diabetes, 51, 1256-1262.
63. Phelps, E. A. (2004). Human emotion and memory: Interactions of the amygdala and hippocampal complex. Current Opinions in Neurobiology, 14, 198-202.
64. Picot, S. J., Zauszniewski, J., & Delgado, C. (1997). Cardiovascular responses of African American female caregivers. Journal of National Black Nurses Association, 9, 3-21.
65. Pinquart, M., & Sorensen, S. (2003). Differences between caregivers and noncaregivers in psychological health and physical health: A meta-analysis. Psychology and Aging, 18, 250-267.
66. Puckett, C. D. (1993). The educational annotation of ICD-9-CM (4th ed.). Reno, NV: Channel Publishing.
67. Rovet, J., Ehrlich, R., & Czuchta, D. (1990). Intellectual characteristics of diabetic children at diagnosis and one year later. Journal of Pediatric Psychology, 15, 775-788.
68. Russo, J., Vitaliano, P. P., Brewer, D. D., Katon, W., & Becker, J. (1995). Psychiatric disorders in spouse caregivers of care recipients with Alzheimer's disease and matched controls: A diathesis-stress model of psychopathology. Journal of Abnormal Psychology, 104, 197-204.
69. Saykin, A. J., Johnson, S. C., Flashman, L. A., McAllister, T. W., Sparling, M., Darcey, T. M., et al. (1999). Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: An fMRI study. Brain, 122, 1963-1971.
70. Schneiderman, N., & Skyler, J. S. (1996). Insulin metabolism, sympathetic nervous system regulation, and coronary heart disease prevention. In K. Orth-Gomer & N. Schneiderman (Eds.), Behavioral medicine approaches to cardiovascular disease prevention (pp. 105-133). Hillsdale, NJ: Erlbaum.
71. Shallice, T., Fletcher, P., Frith, C. D., Grasby, P., Frackowiak, R. S., & Dolan, R. J. (1994, April 14). Brain regions associated with acquisition and retrieval of verbal episodic memory. Nature, 368, 633-635.
72. Shapiro, P. A., Sloan, R. P., Bagiella, E., Kuhl, J. P., Anjilvel, S., & Mann, J. (2000). Cerebral activation, hostility, and cardiovascular control during mental stress. Journal of Psychosomatic Research, 48, 485-491.
73. Shaw, W. S., Patterson, T. L., Ziegler, M. G., Dimsdale, J. E., Semple, S. J., & Grant, I. (1999). Accelerated risk of hypertensive blood pressure recordings among Alzheimer caregivers. Journal of Psychosomatic Research, 46, 215-227.
74. Simmons, R. L., & Miles, N. (1987). Coronary artery bypass grafting in a predominately black group of patients. Journal of the National Medical Association, 7, 593-599.
75. Sinoff, G., & Werner, P. (2003). Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. International Journal of Geriatric Psychiatry, 18, 951-959.
76. Spielberger, C. D., Gorusch, R. L., & Lushene, R. E. (1970). Manual for the State-Trait Anxiety Inventory (Self-Evaluation Questionnaire). Palo Alto, CA: Consulting Psychologists Press.
77. Spillman, B. C., & Pezzin, L. E. (2000). Potential and active family caregivers: Changing networks and the "Sandwich Generation." The Milbank Quarterly, 78, 347-374.
78. Steptoe, A., & Marmot, M. (2003). Burden of psychosocial adversity and vulnerability in middle age: Associations with biobehavioral risk factors and quality of life. Psychosomatic Medicine, 65, 1029-1037.
79. Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997). Is Type II diabetes associated with an increased risk of cognitive dysfunction? Diabetes Care, 20, 438-445.
80. Teri, L., Truax, P., Logsdon, R., Uomoto, J., Zarit, S., & Vitaliano, P. P. (1992). Assessment of behavioral problems in dementia: The revised memory and behavior problems checklist. Psychology and Aging, 7, 622-629.
81. Verhaeghen, P. P., Borchelt, M., & Smith, J. (2003). Relation between cardiovascular and metabolic disease and cognition in very old age: Cross-sectional and longitudinal findings from the Berlin Aging Study. Health Psychology, 22, 559-569.
82. Vitaliano, P. P., Russo, J., Bailey, S., Young, H., & McCann, B. (1993). Psychosocial factors associated104 with cardiovascular reactivity in older individuals. Psychosomatic Medicine, 55, 164-177.
83. Vitaliano, P. P., Scanlan, J. M., Krenz, C., & Fujimoto, W. (1996). Insulin and glucose: Relationships with hassles, anger, and hostility in nondiabetic older adults. Psychosomatic Medicine, 58, 489-499.
84. Vitaliano, P. P., Scanlan, J. M., Krenz, C., Schwartz, R. S., & Marcovina, S. M. (1996). Psychological distress, caregiving, and metabolic variables. Journal of Gerontology: Psychological Sciences, 51B, 290-297.
85. Vitaliano, P. P., Scanlan, J. M., Moe, K., Siegler, I. C., Prinz, P. N., & Ochs, H. D. (1999). Stress, sleep problems, and immune function in persons with cancer histories. Cancer Research, Therapy, and Control, 10, 167-182.
86. Vitaliano, P. P., Scanlan, J. M., Zhang, J., Savage, M. V., Hirsch, I., & Siegler, I. C. (2002). A path model of chronic stress, the metabolic syndrome, and coronary heart disease. Psychosomatic Medicine, 64, 418-435.
87. Vitaliano, P. P., Zhang, J., & Scanlan, J. M. (2003). Is caregiving hazardous to one's physical health? A meta-analysis. Psychological Bulletin, 129, 946-972.
88. Waldstein, S. R., & Elias, M. F. (2003). Introduction to the special section on health and cognitive function. Health Psychology, 22, 555-558.
89. Waldstein, S. R., & Katzel, L. I. (2001). Hypertension and cognitive function. In S. R. Waldstein & M. F. Elias (Eds.), Neuropsychology of cardiovascular disease (pp. 15-36). Mahwah, NJ: Erlbaum.
90. Walker, M., Berrish, T. S., James, A. R., & Alberti, K. G. (1994). Effect of hyperinsulinemia and the function of the pituitary-adrenal axis in healthy man. Clinical Endocrinology, 40, 493-497.
91. Wicker, B., Perrett, D. I., Baron-Cohen, S., & Decety, J. (2003). Being the target of another's emotion: A PET study. Neuropsychologia, 41, 139-146.
92. Zachary, R. A. (1986). Shipley Institute of Living Scale-Revised manual. Los Angeles: Western Psychological Services.