Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 139 B, Issue 1, 2005, Pages 23-27

  Sobell, Janet L ^a   Richard, Christian ^a,b   Wirshing, Donna A ^c   Heston, Leonard L ^d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Association; Case control; Haplotype; RGS4 gene; Schizophrenia

Indexed keywords

DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR; PROTEIN SUBUNIT;

ADULT; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RGS4 GENE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RGS PROTEINS; SCHIZOPHRENIA;

EID: 27644517765     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30221     Document Type: Article

References (23)

1. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265.
2. Bernstein LS, Grillo AA, Loranger SS, Linder ME. 2000. RGS4 binds to membranes through an amphipathic alpha-helix. J Biol Chem 275(24):18520-18526.
3. Brustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS. 2000. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288:678-682.
4. Chen X, Dunham C, Kendler S, Wang X, O'Neill FA, Walsh D, Kendler KS. 2004. Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families. Am J Med Genet 129B(1):23-26.
5. Chowdari KV, Mirnics K, Semwal P, Wood J, Lawrence E, Bhatia T, Deshpande SN, Thelma BK, Ferrell RE, Middleton FA, Devlin B, Levitt P, Lewis DA, Nimgaonkar VL. 2002. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum Mol Genet 11(12):1373-1380.
6. Erdely HA, Lahti RA, Lopez MB, Myers CS, Roberts RC, Tamminga CA, Vogel MW. 2004. Regional expression of RGS4 mRNA in human brain. Eur J Neurosci 19(11):3125-3128.
7. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. 2002. The structure of haplotype blocks in the human genome. Science 296(5576):2225-2229.
8. Geurts M, Hermans E, Maloteaux J-M. 2002. Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum. Neurosci Lett 332(2):146-150.
9. Hollinger S, Hepler JR. 2002. Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling. Pharmacol Rev 54(3):527-559.
10. McVean GA, Myers SR, Hunt S, Deloukas P, Bentley DR, Donnelly P. 2004. The fine-scale structure of recombination rate variation in the human genome. Science 304:581-584.
11. Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P. 2001. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6(3):293-301.
12. Morris DW, Rodgers A, McGhee KA, Schwaiger S, Scully P, Quinn J, Meagher D, Waddington JL, Gill M, Corvin AP. 2004. Confirming RGS4 as a susceptibility gene for schizophrenia. Am J Med Genet 125B(1):50-53.
13. Ni YG, Gold SJ, Iredale PA, Terwilliger RZ, Duman RS, Nestler EJ. 1999. Region-specific regulation of RGS4 (regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: In vivo and in vitro studies. J Neurosci 19(10):3674-3680.
14. Qin ZS, Niu T, Liu JS. 2002. Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms. Am J Hum Genet 71(5):1242-1247.
15. Ross EM, Wilkie TM. 2000. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827.
16. Seltman H, Roeder K, Devlin B. 2003. Evolutionary-based association analysis using haplotype data. Genetic Epidemiol 25(1):48-59.
17. Sobell JL, Heston LL, Sommer SS. 1993. Novel association approach for determining the genetic predisposition to schizophrenia: Case-control resource and testing of a candidate gene. Am J Med Genet 48(1):28-35.
18. Taymans JM, Leysen JE, Langlois X. 2003. Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: Clues for RGS2 and RGS4 functions. J Neurochem 84(5):1118-1127.
19. Taymans JM, Kia HK, Claes R, Cruz C, Leysen J, Langlois X. 2004. Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time. Eur J Neurosci 19(8):2249-2260.
20. Tu Y, Woodson J, Ross EM. 2001. Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to GTPase-activating protein activity. J Biol Chem 276(23):20160-20166.
21. Wang N, Akey JM, Zhang K, Chakraborty R, Jin L. 2002. Distribution of recombination crossovers and the origin of haplotype blocks: The interplay of population history, recombination, and mutation. Am J Hum Genet 71:1227-1234.
22. Williams NM, Preece A, Spurlock G, Norton N, Williams HJ, McCreadie RG, Buckland P, Sharkey V, Chowdari KV, Zammit S, Nimgaonkar V, Kirov G, Owen MJ, O'Donovan MC. 2004. Support for RGS4 as a susceptibility gene for schizophrenia. Biol Psychiatry 55(2):192-195.
23. Zheng B, De Vries L, Gist Farquhar M. 1999. Divergence of RGS proteins: Evidence for the existence of six mammalian RGS subfamilies. Trends Biochem Sci 24(11):411-414.