The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways

Molecular Cancer Therapeutics

Volumn 4, Issue 10, 2005, Pages 1569-1576

  Turbyville, Thomas J ^a,b   Wijeratne, E M Kithsiri ^a   Whitesell, Luke ^b   Gunatilaka, A A Leslie ^a  

^a Environmental Research Laboratory   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; BUTHIONINE SULFOXIMINE; CYSTEINE; CYTOKINE; DIHYDROTERRECYCLIC ACID A; DYE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SESQUITERPENE; TERRECYCLIC ACID A; TERRECYCLIC ACID A METHYL ESTER; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS TERREUS; CELL ACTIVITY; CELL PROTECTION; CELL SURVIVAL; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FLOW CYTOMETRY; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; INFLAMMATION; METABOLITE; MOUSE; NONHUMAN; OPUNTIA; OXIDATIVE STRESS; PRIORITY JOURNAL; RHIZOSPHERE; TRANSCRIPTION INITIATION; TUMOR CELL;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; ASPERGILLUS; CELL GROWTH PROCESSES; FLOW CYTOMETRY; HEAT-SHOCK RESPONSE; HELA CELLS; HUMANS; MICE; NF-KAPPA B; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27644509738     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0050     Document Type: Article

References (23)

1. Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene 2004;23:2907-18.
2. Neckers L, Mimnaugh E, Schulte TW. Hsp90 as an anti-cancer target. Drug Resist Updat 1999;2:165-72.
3. Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 1998; 94:471-80.
4. Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes Dev 2001;15:2134-45.
5. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994;91: 8324-8.
6. Schulte TW, Akinaga S, Soga S, et al. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 1998;3:100-8.
7. Bagatell R, Paine-Murrieta GD, Taylor CW, et al. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res 2000;6:3312-8.
8. Wijeratne EM, Turbyville TJ, Zhang Z, et al. Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert. J Nat Prod 2003;66:1567-73.
9. Schumacher RJ, Hurst R, Sullivan WP, et al. ATP-dependent chaperoning activity of reticulocyte lysate. J Biol Chem 1994;269: 9493-9.
10. Wen J, You KR, Lee SY, Song CH, Kim DG. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem 2002;277:38954-64.
11. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb feverfew directly binds to and inhibits IκB kinase. Chem Biol 2001; 8: 759-66.
12. Ahn SG, Thiele DJ. Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. Genes Dev 2003;17:516-28.
13. Okamoto TTT, Yoshida S, Kawabe T, Redox regulation of NF-κB, in antioxidant and redox regulation of genes. Sen CK, Sies H, Baeuerle PA, editors. San Diego: Academic Press; 2000. p. 203-19.
14. Csermely P, Schnaider T, Soti C, Prohaszka Z, Nardai G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther 1998;79: 129-68.
15. Bacuerle PA. Reactive oxygen species as costimulatory signals of cytokine-induced NF-κB activation pathways. Antioxidant and Redox Regulation of Genes, ed. Chandan KS, Sies H, and Baeuerle PA. 2000, Academic Press: San Diego. 181-201.
16. Aggarwal BB. Nuclear factor-κB: the enemy within. Cancer Cell 2004;6:203-8.
17. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
18. Das KC, White CW. Activation of NF-κB by antineoplastic agents. Role of protein kinase C. J Biol Chem 1997;272:14914-20.
19. Nakanishi C, Toi M. Nuclear factor-κB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005;5:297-309.
20. Huber MA, Azoitei N, Baumann B, et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004;114:569-81.
21. Greten FR, Eckmann L, Greten TF, et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004; 118:285-96.
22. Pikarsky E, Porat RM, Stein I, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 2004; 431:461-6.
23. Greten FR, Karin M. The IKK/NF-κB activation pathway - a target for prevention and treatment of cancer. Cancer Lett 2004; 206:193-9.