Subcellular localization of iron regulatory proteins to Golgi and ER membranes

Journal of Cell Science

Volumn 118, Issue 19, 2005, Pages 4365-4373

  Patton, Stephanie M ^a   Piñero, Domingo J ^b   Surguladze, Nodar ^a   Beard, John ^c   Connor, James R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Endoplasmic reticulum; Golgi apparatus; Iron regulatory proteins; Localization

Indexed keywords

BINDING PROTEIN; CHELERYTHRINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; IRON REGULATORY FACTOR; PHORBOL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; FRACTIONATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; HYPOTHESIS; IRON RESTRICTION; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; STRESS;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; BIOLOGICAL MARKERS; CELL LINE; CHELATING AGENTS; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GOLGI APPARATUS; HOMEOSTASIS; HUMANS; INTRACELLULAR MEMBRANES; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; IRON, DIETARY; IRON-REGULATORY PROTEINS; LIVER; PHENANTHRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUBCELLULAR FRACTIONS; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 27644500118     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02570     Document Type: Article

References (29)

1. Beard, J. L. and Connor, J. R. (2003). Iron status and neural functioning. Annu. Rev. Nutr. 23, 41-58.
2. Borgese, N., Colombo, S. and Pedrazzini, E. (2003). The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane. J. Cell Biol. 161, 1013-1019.
3. Cox, D. W. and Moore, S. D. (2002). Copper transporting P-type ATPases and human disease. J. Bioenerg. Biomembr. 34, 333-338.
4. Crichton, R. R., Wilmet, S., Legssyer, R. and Ward, R. J. (2002). Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J. Inorg. Biochem. 91, 9-18.
5. D'Arrigo, A., Manera, E., Longhi, R. and Borgese, N. (1993). The specific subcellular localization of two isoforms of cytochrome b5 suggests novel targeting pathways. J. Biol. Chem. 268, 2802-2808.
6. Drapier, J. C., Hirling, H., Wietzerbin, J., Kaldy, P. and Kuhn, L. C. (1993). Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J. 12, 3643-3649.
7. Eisenstein, R. S. (2000). Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu. Rev. Nutr. 20, 627-662.
8. Eisenstein, R. S., Tuazon, P. T., Schalinske, K. L., Anderson, S. A. and Traugh, J. A. (1993). Iron-responsive element-binding protein. Phosphorylation by protein kinase C. J. Biol. Chem. 268, 27363-27370.
9. Erlitzki, R., Long, J. C. and Theil, E. C. (2002). Multiple, conserved iron-responsive elements in the 3′-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2. J. Biol. Chem. 277, 42579-42587.
10. Glover, J. and Jacobs, A. (1972). Activity pattern of iron-deficient rats. Br. Med. J. 2, 627-628.
11. Graham, J. M. (1993). Biomembrane Protocols; Methods in Molecular Biology. Totowa, NJ, USA: Humana Press.
12. Guo, B., Yu, Y. and Leibold, E. A. (1994). Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J. Biol. Chem. 269, 24252-24260.
13. Gutteridge, J. M. and Halliwell, B. (1989). Iron toxicity and oxygen radicals. Bailliere's Clin. Haematol. 2, 195-256.
14. Han, J., Day, J. R., Connor, J. R. and Beard, J. L. (2003). Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr. Neurosci. 6, 1-10.
15. Hanson, E. S. and Leibold, E. A. (1998). Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation. J. Biol. Chem 273, 7588-7593.
16. Hunt, J. R., Zito, C. A., Erjavec, J. and Johnson, L. K. (1994). Severe or marginal iron deficiency affects spontaneous physical activity in rats. Am. J. Clin. Nutr. 59, 413-418.
17. Krogh, A., Larsson, B., von Heijne, G. and Sonnhammer, E. L. (2001). Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305, 567-580.
18. Leibold, E. A. and Munro, H. N. (1988). Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. USA 85, 2171-2175.
19. Pantopoulos, K. and Hentze, M. W. (1995). Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J. 14, 2917-2924.
20. Pinero, D. J., Li, N. Q., Connor, J. R. and Beard, J. L. (2000). Variations in dietary iron alter brain iron metabolism in developing rats. J. Nutr. 130, 254-263.
21. Pinero, D. J., Li, N., Hu, J., Beard, J. L. and Connor, J. R. (2001). The intracellular location of iron regulatory proteins is altered as a function of iron status in cell cultures and rat brain. J. Nutr. 131, 2831-2836.
22. Roy, A., Solodovnikova, N., Nicholson, T., Antholine, W. and Walden, W. E. (2003). A novel eukaryotic factor for cytosolic Fe-S cluster assembly. EMBO J. 22, 4826-4835.
23. Samaniego, F., Chin, J., Iwai, K., Rouault, T. A. and Klausner, R. D. (1994). Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J. Biol. Chem. 269, 30904-30910.
24. Schalinske, K. L. and Eisenstein, R. S. (1996). Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells. J. Biol. Chem. 271, 7168-7176.
25. Schalinske, K. L., Anderson, S. A., Tuazon, P. T., Chen, O. S., Kennedy, M. C. and Eisenstein, R. S. (1997). The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites. Biochemistry 36, 3950-3958.
26. Tong, W. H. and Rouault, T. (2000). Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J. 19, 5692-5700.
27. Wattenberg, B. and Lithgow, T. (2001). Targeting of C-terminal (tail)-anchored proteins: understanding how cytoplasmic activities are anchored to intracellular membranes. Traffic 2, 66-71.
28. Youdim, M. B., Ben-Shachar, D. and Yehuda, S. (1989). Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am. J. Clin. Nutr. 50, 607-615; discussion 615-617.
29. Zhang, J., Kang, D. E., Xia, W., Okochi, M., Mori, H., Selkoe, D. J. and Koo, E. H. (1998). Subcellular distribution and turnover of presenilins in transfected cells. J. Biol. Chem. 273, 12436-12442.